3β-acetoxy-5α-cholestano<5,6-b>N-phthalimidoaziridine | 118517-20-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-acetoxy-5α-cholestano<5,6-b>N-phthalimidoaziridine
• 英文别名: 3beta-Acetoxy-5alpha-cholestano(5,6-b)-N-phthalimidoaziridine；[(1S,2R,5S,7R,9S,11S,12S,15R,16R)-8-(1,3-dioxoisoindol-2-yl)-2,16-dimethyl-15-[(2R)-6-methylheptan-2-yl]-8-azapentacyclo[9.7.0.02,7.07,9.012,16]octadecan-5-yl] acetate
• CAS: 118517-20-7
• 化学式: C₃₇H₅₂N₂O₄
• 分子量: 588.831
• InChiKey: YPVNQSYTFZVXIY-BENLHTCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  66.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  胆固醇醋酸酯 、 氨基邻苯二甲胺 在 碘苯二乙酸 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到3β-acetoxy-5α-cholestano<5,6-b>N-phthalimidoaziridine
  参考文献：
  名称：

  Aziridination of alkenes with N-substituted hydrazines mediated by iodobenzene diacetate

  摘要：

  Aziridination of a variety of alkenes with N-substituted hydrazines mediated by iodobenzene diacetate under mild conditions (K2CO3, CH2Cl2) and ambient temperature were achieved in good to excellent yields (up to 99%), and conversions. The practicality and simplicity of this C-N bond formation protocol was exemplified by its application to the aziridination of cholesteryl acetate in a stereoselective manner. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.01.127

文献信息

• Aziridination of alkenes with N-substituted hydrazines mediated by iodobenzene diacetate
  作者：Jiayin Li、Jiang-Lin Liang、Philip Wai Hong Chan、Chi-Ming Che

  DOI：10.1016/j.tetlet.2004.01.127

  日期：2004.3

  Aziridination of a variety of alkenes with N-substituted hydrazines mediated by iodobenzene diacetate under mild conditions (K2CO3, CH2Cl2) and ambient temperature were achieved in good to excellent yields (up to 99%), and conversions. The practicality and simplicity of this C-N bond formation protocol was exemplified by its application to the aziridination of cholesteryl acetate in a stereoselective manner. (C) 2004 Elsevier Ltd. All rights reserved.