2-ethyl-6-methyl-pyrido[1,2-a]pyrimidin-4-one | 63736-04-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 2-ethyl-6-methyl-pyrido[1,2-a]pyrimidin-4-one
• 英文别名: 2-Ethyl-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one；2-ethyl-6-methylpyrido[1,2-a]pyrimidin-4-one
• CAS: 63736-04-9
• 化学式: C₁₁H₁₂N₂O
• 分子量: 188.229
• InChiKey: POSQFPSLJAVXQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-ethyl-6-methyl-pyrido[1,2-a]pyrimidin-4-one 以70%的产率得到
  参考文献：
  名称：

  HERMECZ I.; MESZAROS Z.; VASVARI-DEBRECZY L.; HORVATH A.; HORVATH G.; PON+, J. CHEM.SOC. PERKIN TRANS., PART 1 , 1977, NO 7, 789-795

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-6-甲基吡啶 、 丙酰乙酸乙酯 、 三氯氧磷 生成 2-ethyl-6-methyl-pyrido[1,2-a]pyrimidin-4-one
  参考文献：
  名称：

  HERMECZ I.; MESZAROS Z.; VASVARI-DEBRECZY L.; HORVATH A.; HORVATH G.; PON+, J. CHEM.SOC. PERKIN TRANS., PART 1 , 1977, NO 7, 789-795

  摘要：

  DOI：

文献信息

• AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF
  申请人：Sanford-Burnham Medical Research Institute

  公开号：US20170197958A1

  公开（公告）日：2017-07-13

  Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions. The present invention is based on the seminal discovery of a series of potent small molecule agonists of the apelin receptor, which are useful for the treatment of diseases including heart failure, chronic kidney disease, hypertension, and metabolic disorders such as insulin resistance/diabetes and obesity. The compounds disclosed herein are highly specific for the apelin receptor versus the angiotensin II receptor (ATI).
• [EN] AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF<br/>[FR] AGONISTES DU RÉCEPTEUR DE L'APÉLINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SANFORD BURNHAM MED RES INST

  公开号：WO2015184011A2

  公开（公告）日：2015-12-03

  Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions.
• HERMECZ I.; MESZAROS Z.; VASVARI-DEBRECZY L.; HORVATH A.; HORVATH G.; PON+, J. CHEM.SOC. PERKIN TRANS., PART 1 <JCPK-BH>, 1977, NO 7, 789-795
  作者：HERMECZ I.、 MESZAROS Z.、 VASVARI-DEBRECZY L.、 HORVATH A.、 HORVATH G.、 PON+

  DOI：——

  日期：——