[4-(4-methyl-piperazin-1-yl)-phenyl]-carbamic acid tert-butyl ester | 915020-33-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: [4-(4-methyl-piperazin-1-yl)-phenyl]-carbamic acid tert-butyl ester
• 英文别名: [4-(4-Methyl-piperazin-1-yl)-phenyl]carbamic acid tert-butyl ester；tert-butyl N-[4-(4-methylpiperazin-1-yl)phenyl]carbamate
• CAS: 915020-33-6
• 化学式: C₁₆H₂₅N₃O₂
• 分子量: 291.393
• InChiKey: MEJSFOSXCWYURJ-UHFFFAOYSA-N

物化性质

• 沸点：
  382.1±37.0 °C(Predicted)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [4-(4-methyl-piperazin-1-yl)-phenyl]-carbamic acid tert-butyl ester 在 盐酸 、 N-氯代丁二酰亚胺 作用下， 以 1,4-二氧六环 、 异丙醇 为溶剂， 反应 5.0h， 生成 1-(4-氨基-2-氯苯基)-4-甲基哌嗪
  参考文献：
  名称：

  WO2006/122806

  摘要：

  公开号：
• 作为产物：
  描述：

  4-(4-甲基哌嗪)苯胺 、 二碳酸二叔丁酯 在 乙酸乙酯 、 水 、 magnesium sulfate 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成 [4-(4-methyl-piperazin-1-yl)-phenyl]-carbamic acid tert-butyl ester
  参考文献：
  名称：

  1,3-Dihydro-Imidazo [4,5-C] Quinolin-2-Ones as Lipid Kinase Inhibitors

  摘要：

  本发明涉及公式（I）的新有机化合物，其制备方法，其在治疗人体或动物的过程中的应用，其单独或与一种或多种其他药物活性化合物结合使用，用于治疗炎症或阻塞性呼吸道疾病，如哮喘，与移植相关的常见疾病或增生性疾病，如肿瘤疾病。

  公开号：

  US20080194579A1

文献信息

• 1,3-Dihydro-Imidazo [4,5-C] Quinolin-2-Ones as Lipid Kinase Inhibitors
  申请人：Garcia-Echeverria Carlos

  公开号：US20080194579A1

  公开（公告）日：2008-08-14

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及公式（I）的新有机化合物，其制备方法，其在治疗人体或动物的过程中的应用，其单独或与一种或多种其他药物活性化合物结合使用，用于治疗炎症或阻塞性呼吸道疾病，如哮喘，与移植相关的常见疾病或增生性疾病，如肿瘤疾病。
• 1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS
  申请人：Garcia-Echeverria Carlos

  公开号：US20100056558A1

  公开（公告）日：2010-03-04

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及公式（I）的新有机化合物，其制备方法，其在处理人或动物体的过程中的应用，其单独使用或与一个或多个其他药物活性化合物结合使用，用于治疗炎症或阻塞性呼吸道疾病，如哮喘，与移植有关的常见疾病或增生性疾病，如肿瘤疾病。
• 1,3-dihydro-imidazo[4,5-C]quinolin-2-ones as lipid kinase inhibitors
  申请人：Novartis AG

  公开号：US07994170B2

  公开（公告）日：2011-08-09

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及式(I)的新型有机化合物，其制备方法，应用于人或动物体内处理过程，使用该化合物-单独或与一种或多种其他药物活性化合物结合-用于治疗炎症或阻塞性呼吸道疾病，如哮喘，常见于移植相关疾病或增生性疾病，如肿瘤疾病。
• 1,3-Dihydro-imidazo[4,5-c]quinolin-2-ones as Lipid Kinase Inhibitors
  申请人：GARCIA-ECHEVERRIA Carlos

  公开号：US20110251202A1

  公开（公告）日：2011-10-13

  The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

  本发明涉及式(I)的新型有机化合物，其制备方法，其在用于治疗人或动物体内的过程中的应用，其使用-单独或与一种或多种其他药物活性化合物结合使用-用于治疗炎症性或阻塞性呼吸道疾病，如哮喘，与移植有关的常见疾病或增殖性疾病，如肿瘤疾病。
• 1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase inhibitors
  申请人：Garcia-Echeverria Carlos

  公开号：US08431592B2

  公开（公告）日：2013-04-30

  The invention relates to methods of treatment of a proliferative disease which responds to inhibition of PI3-Kinase-related protein kinases, particularly the PI3-kinase, by administration of a novel organic compound of formula (I) to a human or animal requiring such treatment; and methods of treatment of inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease, by administration of such compound.

  该发明涉及治疗对PI3-Kinase相关蛋白激酶（特别是PI3-kinase）抑制反应的增生性疾病的方法，通过给需要此类治疗的人类或动物注射公式（I）的新有机化合物；以及通过给予此类化合物的方法来治疗炎症性或阻塞性呼吸道疾病，如哮喘、与移植相关的常见疾病或增生性疾病，如肿瘤疾病。