AR-C-89855 hydrochloride | 189011-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: AR-C-89855 hydrochloride
• 英文别名: 3-[2-(4-hydroxy-2-oxo-3H-1,3-benzothiazol-7-yl)ethylamino]-N-[2-[2-(4-methylphenyl)ethoxy]ethyl]propane-1-sulfonamide;hydrochloride
• CAS: 189011-90-3
• 化学式: C23H32ClN3O5S2
• 分子量: 530.1
• InChiKey: LMUUVBDGDSXLAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.73
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  150
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  methyl 3-[2-[2-(4-methylphenyl)ethoxy]ethylaminosulphonyl]propanoate 、 diisobutylaluminum hydride 、 7-(2-aminoethyl)-4-hydroxy-1,3-benzothiazol-2(3H)-one hydrochloride 、 氰基硼氢化钠 生成 AR-C-89855 hydrochloride
  参考文献：
  名称：

  Intermediates for making benzothiazolone derivatives

  摘要：

  式I的化合物，包括其光学异构体，其中X代表--SO.sub.2 NH--或--NHSO.sub.2 --，p、q和r独立地代表2或3，Y代表可选地被烷基或卤素取代的噻吩基，或可选地被烷基或卤素取代的苯硫基或苯基，每个R独立地代表H或烷基，以及其药学上可接受的盐、酯和酰胺。

  公开号：

  US05973167A1

文献信息

• Benzothiazolone derivatives
  申请人：Astra Pharmaceuticals Ltd.

  公开号：US06008365A1

  公开（公告）日：1999-12-28

  A compound of formula I, including optical isomers thereof, ##STR1## wherein X represents --SO.sub.2 NH-- or --NHSO.sub.2 --, p, q and r independently represent 2 or 3, Y represents thienyl optionally substituted by alkyl or halogen, or phenylthio- or phenyl optionally substituted by akyl or halogen, and each R independently represents H or alkyl, and pharmaceutically acceptable salts, esters and amides thereof.

  化合物I的式子，包括其光学异构体，##STR1## 其中X代表--SO.sub.2 NH--或--NHSO.sub.2 --，p、q和r独立地代表2或3，Y代表噻吩，可选地被烷基或卤素取代，或苯硫醚或苯，可选地被烷基或卤素取代，每个R独立地代表H或烷基，以及其药学上可接受的盐、酯和酰胺。
• Inhaler counter
  申请人：ASTRAZENECA AB

  公开号：US10994082B2

  公开（公告）日：2021-05-04

  An inhaler for delivery of a medicament by inhalation is disclosed. The inhaler comprises a dispensing mechanism, the dispensing mechanism being configured to dispense a dose of medicament on actuation. The inhaler further comprises a dose counting mechanism comprising a counter and a translating member. The translating member comprises a pawl. The counter comprises a first count wheel, a second count wheel and an intermediate wheel engaged with the second count wheel and in selective engagement with the first count wheel. When the inhaler is fired to dispense a dose of medicament, the dispensing mechanism moves the translating member in a substantially linear direction. The pawl thus rotates the first count wheel, and as the first count wheel rotates, the intermediate wheel is selectively engaged thereby selectively rotating the second count wheel to count the doses of the inhaler.

  本发明公开了一种通过吸入给药的吸入器。该吸入器包括一个配药机构，配药机构被配置为在启动时配出一定剂量的药物。吸入器还包括一个剂量计数机构，该机构由一个计数器和一个平移部件组成。平移部件包括一个棘爪。计数器包括一个第一计数轮、一个第二计数轮和一个与第二计数轮啮合并与第一计数轮选择性啮合的中间轮。当启动吸入器分配一定剂量的药物时，分配机构沿大致线性方向移动平移部件。棘爪带动第一计数轮旋转，当第一计数轮旋转时，中间轮选择性地啮合，从而选择性地转动第二计数轮，对吸入器的剂量进行计数。
• BENZOTHIAZOLONE DERIVATIVES
  申请人：Astra Pharmaceuticals Limited

  公开号：EP0850232B1

  公开（公告）日：2000-03-15
• POLYACRYLATE COATED INHALATION DEVICE
  申请人：AstraZeneca AB

  公开号：EP1474197B1

  公开（公告）日：2008-04-30
• INHALER COUNTER
  申请人：ASTRAZENECA AB

  公开号：US20190175849A1

  公开（公告）日：2019-06-13

  An inhaler for delivery of a medicament by inhalation is disclosed. The inhaler comprises a dispensing mechanism, the dispensing mechanism being configured to dispense a dose of medicament on actuation. The inhaler further comprises a dose counting mechanism comprising a counter and a translating member. The translating member comprises a pawl. The counter comprises a first count wheel, a second count wheel and an intermediate wheel engaged with the second count wheel and in selective engagement with the first count wheel. When the inhaler is fired to dispense a dose of medicament, the dispensing mechanism moves the translating member in a substantially linear direction. The pawl thus rotates the first count wheel, and as the first count wheel rotates, the intermediate wheel is selectively engaged thereby selectively rotating the second count wheel to count the doses of the inhaler.