2-羟基-N-(2-羟乙基)乙酰胺 | 3586-25-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-羟基-N-(2-羟乙基)乙酰胺
• 英文名称: 2-hydroxy-N-(2-hydroxyethyl)acetamide
• 英文别名: N-glycolylethanolamine；N-(2-hydroxy-ethyl)-glycolamide；N-(2-Hydroxy-aethyl)-glykolamid；N-(2-Hydroxy-aethyl)-hydroxyacetamid；Glykolsaeure-(2-hydroxy-aethylamid)；N-(2-hydroxyethyl)-glycolic acid amide
• CAS: 3586-25-2
• 化学式: C₄H₉NO₃
• mdl: MFCD10048462
• 分子量: 119.12
• InChiKey: NAOVCEBACWAEDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-羟基-N-(2-羟乙基)乙酰胺 生成 (4,5-dihydrooxazol-2-yl)methanol
  参考文献：
  名称：

  Oxidorhenium(V) 配合物与恶唑啉基甲氧基配体 - 结构和催化环氧化

  摘要：

  [ReOCl3(PPh3)2] 与（4,5-二氢恶唑-2-基）甲醇及其三种甲基取代衍生物（2a-2d）在沸腾的丙酮或四氢呋喃中反应得到 [ReOCl2 (PPh3)(2a–2d)] (3a–3d) 作为蓝色结晶材料，收率良好。通过 1H、13C、31P 核磁共振和红外光谱、质谱、元素分析和单晶 X 射线衍射分析对配合物进行了表征。所有配合物都显示出扭曲的八面体几何形状，并且发现仅含有一个恶唑基配体，取代了前体配合物 [ReOCl3(PPh3)2] 中的一个 PPh3 分子和一个氯离子。该配合物被测试作为环辛烯与 3 当量环氧化的催化剂。叔丁基过氧化氢 (TBHP)。包含 (4,

  DOI：

  10.1002/ejic.201100538
• 作为产物：
  描述：

  羟乙酸甲酯 、 C.I.酸性橙108 生成 2-羟基-N-(2-羟乙基)乙酰胺
  参考文献：
  名称：

  Nu-substituted amide and method for preparing the same

  摘要：

  公开号：

  US02347494A1

文献信息

• Metal Template Assisted Proximal Arrangement of a Nucleophile and an Electrophile: Site-Selective Acylation of α-Hydroxyamides in Polyols
  作者：Yasuhiro Nishikawa、Kohei Takemoto、Kana Matsuda、Risa Tanaka、Akira Arashima、Kanako Ito、Yuki Kamezawa、Yuna Hori、Osamu Hara

  DOI：10.1021/acs.orglett.8b01288

  日期：2018.6.1

  Site-selective acylation of α-hydroxyl groups in amides has been achieved in the presence of other primary hydroxyl groups with intrinsic high reactivity. In this methodology, a relatively stable pyridine aldoxime ester was exploited as an acyl donor to suppress undesired acylation. The catalytic activation of a pyridine aldoxime ester with a Lewis acid produced a cationic complex, which preferentially

  在存在具有固有高反应性的其他伯羟基的情况下，已经实现了酰胺中α-羟基的位点选择性酰化。在这种方法中，相对稳定的吡啶醛肟肟被用作酰基供体，以抑制不希望的酰化反应。吡啶醛肟肟与路易斯酸的催化活化作用产生了阳离子络合物，该阳离子络合物通过模板效应优先吸引了路易斯碱性α-羟基酰胺，从而促进了o-酰化反应。
• [EN] NOVEL COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS UTILISÉS COMME INHIBITEURS DE L'INDOLÉAMINE 2,3-DIOXYGÉNASE
  申请人：MERCK SHARP & DOHME

  公开号：WO2017106062A1

  公开（公告）日：2017-06-22

  Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme:(I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

  本文披露了以下公式（I）的化合物，这些化合物是IDO酶的抑制剂：（I）。本文还披露了这些化合物在潜在治疗或预防IDO相关疾病或紊乱中的用途。本文还披露了包含这些化合物的组合物。本文还披露了这些组合物在潜在治疗或预防IDO相关疾病或紊乱中的用途。
• Biosynthesis of Penicillins. VII.¹ Oxy- and Mercaptoacetic Acids
  作者：Quentin F. Soper、Calvert W. Whitehead、Otto K. Behrens、Joseph J. Corse、Reuben G. Jones

  DOI：10.1021/ja01189a003

  日期：1948.9
• Synthesis and evaluation of in vitro anti-tuberculosis activity of N-substituted glycolamides
  作者：Fereidoon Daryaee、Farzad Kobarfard、Ali Khalaj、Parisa Farnia

  DOI：10.1016/j.ejmech.2008.02.022

  日期：2009.1

  On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2,2-dimethyl-5-oxo-1,3-dioxolane) with the proper amines. The minimum inhibitory concentration (MIC) was determined against M. tuberculosis H(37)Rv in BACTEC 12B medium, using the Microplate Alamar Blue Assay (MABA). Among the synthesized compounds, all those with disubstituted amide structure accompanied by one or two heteroatom(s) with loan pair(s) of electrons atom(s) P to the amide nitrogen demonstrated moderate anti-tuberculosis activity and all the monosubstituted amides showed no activity at all. (C) 2008 Elsevier Masson SAS. All rights reserved.
• 2-OXO-2-({2-[(phenylcarbamoyl)oxy]ethyl} amino)ethyl phenylcarbamate as an eco-friendly insecticidal agent against spodoptera littoralis (boisd.)
  申请人：KING FAISAL UNIVERSITY

  公开号：US12035717B1

  公开（公告）日：2024-07-16

  Synthesis of a compound 2-oxo-2-(2-[(phenylcarbamoyl)oxy]ethyl}amino)ethyl phenylcarbamate and its use as an insecticidal agent.