2-羟基吩嗪-1-羧酸 | 4075-25-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2-羟基吩嗪-1-羧酸
• 英文名称: 2-Hydroxyphenazin-1-carbonsaeure
• 英文别名: 2-Hydroxyphenazine-1-carboxylic acid；2-hydroxyphenazine-1-carboxylic acid
• CAS: 4075-25-6
• 化学式: C₁₃H₈N₂O₃
• 分子量: 240.218
• InChiKey: GXLWPTUCVZRTBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.3
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 2-羟基吩嗪-1-羧酸 生成 2-Methoxyphenazin-1-carbonsaeuremethylester
  参考文献：
  名称：

  Neuenhaus, W.; Roemer, A.; Budzikiewicz, H., Zeitschrift für Naturforschung. Teil B, Anorganische Chemie, organische Chemie, 1980, vol. 35, # 3, p. 385 - 388

  摘要：

  DOI：
• 作为产物：
  描述：

  Di-(2-hydroxy-1-phenazinyl)methan 在 ammonium peroxydisulfate 、 silver nitrate 作用下， 以 溶剂黄146 为溶剂， 反应 12.0h， 生成 2-羟基吩嗪-1-羧酸
  参考文献：
  名称：

  Neuenhaus, W.; Roemer, A.; Budzikiewicz, H., Zeitschrift für Naturforschung. Teil B, Anorganische Chemie, organische Chemie, 1980, vol. 35, # 3, p. 385 - 388

  摘要：

  DOI：

文献信息

• Haptenes and Conjugates Derived from Pyocyanin, Antibodies Thereof, and Immunichemical Method for Detecting Infections Caused by Pseudomonas Aeruginosa
  申请人：Marco Colas Maria Pilar

  公开号：US20160033489A1

  公开（公告）日：2016-02-04

  The present invention relates to a compound of general formula I and to the use thereof as a hapten. An object of the present invention is also a conjugate of said compound I with a carrier protein or fragment thereof, with a detectable labelling agent, or with a polymer or support, and to the use thereof for producing antibodies. Furthermore, the present invention also relates to a method for the detection and/or quantification of 1-hydroxyphenazine and/or pyocyanin using said antibodies and conjugates for the detection of infections caused by Pseudomonas aeruginosa.

  本发明涉及一种一般式I的化合物以及其作为半抗原的用途。本发明的另一个目的是将所述化合物I与载体蛋白或其片段、可检测标记剂或聚合物或支持物质结合，以及将其用于产生抗体。此外，本发明还涉及一种利用所述抗体和结合物检测和/或定量1-羟基苯并嗪和/或蓝蛋白，用于检测由铜绿假单胞菌引起的感染的方法。
• Method for protecting plants from nematodes
  申请人：STINE SEED FARM, INC.

  公开号：EP0350244A2

  公开（公告）日：1990-01-10

  The invention provides a method for protecting a plant from nematodes which comprises the step of inoculating said plant with a nematode-inhibiting strain of P. cepacia which strain colonizes said plant. Root inoculation of a plant with nematode-inhibitory P. cepacia results in protection of the plant roots from nematode invasion. Foliar inoculation of the plant with these P. cepacia strains results in protection of the above-ground portions of the plant from nematodes. Direct or indirect inoculation of seeds with nematode-inhibitory strains of P. cepacia can establish colonization of roots, stems and leaves of plants, and thus result in protection of both roots and above-ground plant parts. The inoculum may be applied for example in the vicinity of a seed or young plant or it may be applied directly to a seed or to the leaves of the plant. Any plant colonized by the nematode-inhibiting P. cepacia of this invention may be protected against nematodes. The invention further provides a preparation for protecting a plant from nematodes, which comprises P. cepacia M36, NRRL B-18379, or P. cepacia SG17, NRRL B-18378, and a carrier.

  本发明提供了一种保护植物免受线虫侵害的方法，该方法包括给所述植物接种抑制线虫的 P. cepacia 菌株，该菌株在所述植物上定植。给植物根部接种抑制线虫的 P. cepacia 菌株，可保护植物根部免受线虫入侵。用这些 P. cepacia 菌株对植物进行叶面接种，可保护植物地上部分免受线虫侵害。用抑制线虫的 P. cepacia 菌株直接或间接接种种子，可在植物的根、茎和叶上建立定殖，从而保护植物的根部和地上部分。接种体可以施用在种子或幼苗附近，也可以直接施用在种子或植物叶片上。任何被本发明的抑制线虫的 P. cepacia 定殖的植物都可免受线虫的侵害。本发明进一步提供了一种保护植物免受线虫侵害的制剂，它包括 P. cepacia M36，NRRL B-18379，或 P. cepacia SG17，NRRL B-18378 和载体。
• HAPTENES AND CONJUGATES DERIVED FROM PYOCYANIN, ANTIBODIES THEREOF, AND IMMUNOCHEMICAL METHOD FOR DETECTING INFECTIONS CAUSED BY PSEUDOMONAS AERUGINOSA
  申请人：Consejo Superior De Investigaciones Científicas (CSIC)

  公开号：EP2966066A1

  公开（公告）日：2016-01-13

  The invention relates to a compound of general formula (I) and to the use thereof as a haptene. The invention also relates to a conjugate of said compound I with a carrier protein or fragment thereof, with a detectable marking agent, or with a polymer or support, and to the use thereof for producing antibodies. The invention also relates to a method for the detection and/or quantification of 1-hydroxyphenazine and/or pyocyanin using said antibodies and conjugates for the detection of infections caused by Pseudomonas aeruginosa.

  本发明涉及通式 (I) 的化合物及其作为庚烯的用途。 本发明还涉及上述化合物 I 与载体蛋白或其片段、与可检测的标记剂、或与聚合物或支持物的共轭物，以及将其用于生产抗体。本发明还涉及一种使用所述抗体和共轭物检测和/或定量 1-羟基吩嗪和/或焦花青素的方法，用于检测铜绿假单胞菌引起的感染。
• Haptens and conjugates derived from pyocyanin, antibodies thereof, and immunochemical method for detecting infections caused by Pseudomonas aeruginosa
  申请人：Consejo Superior De Investagaciones Cientificas (CSIC)

  公开号：US10422791B2

  公开（公告）日：2019-09-24

  The present invention relates to a compound of general formula I and to the use thereof as a hapten. An object of the present invention is also a conjugate of said compound I with a carrier protein or fragment thereof, with a detectable labelling agent, or with a polymer or support, and to the use thereof for producing antibodies. Furthermore, the present invention also relates to a method for the detection and/or quantification of 1-hydroxyphenazine and/or pyocyanin using said antibodies and conjugates for the detection of infections caused by Pseudomonas aeruginosa.

  本发明涉及通式 I 的化合物及其作为合剂的用途。 本发明的另一个目的是将所述化合物 I 与载体蛋白或其片段、可检测的标记剂或聚合物或支持物共轭，并利用其生产抗体。此外，本发明还涉及一种使用所述抗体和共轭物检测和/或定量 1-羟基吩嗪和/或焦花青素的方法，用于检测铜绿假单胞菌引起的感染。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。