N-[[9-[(hexylamino)methyl]-1,4,7,10,13-pentaoxacyclopentadec-2-yl]methyl]hexan-1-amine | 92283-96-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[[9-[(hexylamino)methyl]-1,4,7,10,13-pentaoxacyclopentadec-2-yl]methyl]hexan-1-amine
• CAS: 92283-96-0
• 化学式: C₂₄H₅₀N₂O₅
• 分子量: 446.671
• InChiKey: DSMAOVDVEZIILW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  31
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.2
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-[[9-[(hexylamino)methyl]-1,4,7,10,13-pentaoxacyclopentadec-2-yl]methyl]hexan-1-amine 、 1,2-cis-cyclohexanedicarboxylic anhydride 以 四氢呋喃 为溶剂， 反应 48.0h， 以57%的产率得到2,2'-(1,4,7,10,13-pentaoxacyclopentadecane-2,9-diyl)-bis[methylene(hexylimino)carbonyl]biscyclohexanecarboxylic acid
  参考文献：
  名称：

  Double Uphill Transport of Ca²⁺−Na⁺ or Ca²⁺−K⁺ in Opposite Directions by Lipophilic Crown Ethers with Two Carboxylic Acid Moieties

  摘要：

  A variety of lipophilic crown ethers containing two carboxylic acid moieties were prepared, and their transport abilities were estimated in the double uphill transport system of Ca2+-Na+ or Ca2+-K+ by pH control through a bulk liquid membrane using dichloromethane. As expected, 15-crown-5 and 18-crown-6 derivatives were found to be effective for Ca2+-Na+ and Ca2+-K+ exchange systems, respectively. As a result, the calcium ion was concentrated in the acidic phase, and the sodium ion or potassium ion was concentrated in the other phase. In addition to the structure of the carriers, a proper selection of the transport conditions was one of the crucial factors for realizing this double uphill transport system. A simple combination of the active transporter of the calcium ion and the passive carrier for the sodium ion was also found to enable the exchange between the calcium and sodium ions against their concentration gradients. When two ionophores effective for Ca2+-K+ and K+-Na+ exchange systems, respectively, were used at the same time, the calcium and potassium ions were concentrated in the acidic phase, whereas the sodium ion was concentrated in the basic phase.

  DOI：

  10.1021/jo970696n
• 作为产物：
  描述：

  乙二醇二缩水甘油醚 在 sodium 、 叔丁醇 作用下， 以 1,4-二氧六环 为溶剂， 反应 6.5h， 生成 N-[[9-[(hexylamino)methyl]-1,4,7,10,13-pentaoxacyclopentadec-2-yl]methyl]hexan-1-amine
  参考文献：
  名称：

  Synthesis of Bis[aminomethyl]crown Ethers

  摘要：

  DOI：

  10.1055/s-1983-30272

文献信息

• Complexation Property of a Novel Macrobicyclic Polyether with Two Amide Moieties toward Alkali Metal and Alkaline Earth Metal Cations
  作者：Yohji Nakatsuji、Toshinori Inoue、Araki Masuyama、Mitsuo Okahara

  DOI：10.1246/bcsj.65.3490

  日期：1992.12

  A new type of macrobicyclic compound, which was prepared by the reaction of 2,9-bis[(ethylamino)methyl]-15-crown-5 with sebacoyl dichloride, has shown a selective complexation property toward K+ and Ba2+ cations based on data obtained with potentiometric titration and solvent extraction. This finding was reasonably explained by considering the cooperative binding of the amide moieties and the crown

  2,9-双[(乙氨基)甲基]-15-冠-5与癸二酰二氯反应制备的新型大双环化合物，根据获得的数据显示出对K+和Ba2+阳离子的选择性络合特性电位滴定法和溶剂萃取法。通过考虑酰胺部分和冠环的协同结合，可以合理地解释这一发现。通过将其与具有一个或两个酰胺侧臂的套索醚的络合能力进行比较，发现羰基氧的配位方向显着影响其络合性能。
• MAEDA, HIROKAZU;KIKUI, TAKASHI;NAKATSUJI, YOHJI;OKAHARA, MITSUO, SYNTHESIS, 1983, N 3, 185-187
  作者：MAEDA, HIROKAZU、KIKUI, TAKASHI、NAKATSUJI, YOHJI、OKAHARA, MITSUO

  DOI：——

  日期：——
• JPS5962583A
  申请人：——

  公开号：JPS5962583A

  公开（公告）日：1984-04-10