1-[(1R)-1-phenylethyl]-azetidine-3-ol | 116196-12-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-[(1R)-1-phenylethyl]-azetidine-3-ol
• 英文别名: 1-((1R)-1-phenylethyl)azetidin-3-ol；1-[(1R)-1-phenylethyl]azetidin-3-ol
• CAS: 116196-12-4
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: DILWWMFEHWWBCX-SECBINFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-chloro-3-[(1R)-1-phenylethylamino]propan-2-ol 在 sodium methylate 、 三乙胺 作用下， 以 甲醇 为溶剂， 生成 1-[(1R)-1-phenylethyl]-azetidine-3-ol
  参考文献：
  名称：

  Higgins, Robert H.; Watson, Monique R.; Faircloth, William J., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 383 - 387

  摘要：

  DOI：

文献信息

• ACID ADDITION SALTS OF SYNTHETIC INTERMEDIATES FOR CARBAPENEM ANTIBIOTICS AND PROCESSES FOR PREPARING THE SAME
  申请人：Kim Chang-Seob

  公开号：US20100274003A1

  公开（公告）日：2010-10-28

  The present invention provides a process for preparing an acid addition salt of a synthetic intermediate for carbapenem antibiotics and a novel acid addition salt of a synthetic intermediate for carbapenem antibiotics obtained from the process. The present invention also provides a process for preparing a carbapenem antibiotic using the acid addition salt. According to the process of the present invention, an acid addition salt of a synthetic intermediate for carbapenem antibiotics can be prepared in a high yield and high purity, without conducting column chromatography. Thus, the process of the present invention can be applied to mass production with an industrial scale. Furthermore, since the acid addition salts have solid forms, they are easy to handle and keep in a manufacturing site.

  本发明提供了一种用于制备碳青霉烯抗生素的合成中间体的酸性加成盐的方法，以及通过该方法获得的新的碳青霉烯抗生素合成中间体的酸性加成盐。本发明还提供了一种使用该酸性加成盐制备碳青霉烯抗生素的方法。根据本发明的过程，可以在不进行柱色谱的情况下，以高收率和高度纯净地制备碳青霉烯抗生素的合成中间体的酸性加成盐。因此，本发明的过程适用于工业规模的大规模生产。而且，由于酸性加成盐具有固态形式，因此在制造现场易于处理和保存。
• Alkyl ether derivatives or salts thereof
  申请人：Saitoh Akihito

  公开号：US20060194781A1

  公开（公告）日：2006-08-31

  An alkyl ether derivative represented by the general formula: wherein each of R 1 and R 2 represents one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group, an alkenyl group, an alkenyloxy group, an amino group, an alkylsulfonyl group, an arylsulfonyl group, a carbamoyl group, a heterocyclic group, a hydroxyl group, a carboxyl group, a nitro group, an oxo group and the like; R 3 is an alkylamino group, an amino group, a hydroxyl group or the like; the ring A is a 5-membered or 6-membered heteroaromatic ring or a benzene ring; each of m and n is an integer of 1 to 6; and p is an integer of 1 to 3, or its salt has activity to protect neurons, activity to accelerate nerve regeneration and activity to accelerate neurite extension and hence is useful as a therapeutic agent for diseases in central and peripheral nerves.

  一种烷基醚衍生物，其通式表示为：其中R1和R2各自表示氢原子、卤素原子、烷基、芳基、芳基烷基、烷氧基、芳氧基、烷硫基、芳硫基、烯基、烯氧基、氨基、烷基磺酰基、芳基磺酰基、氨基甲酰基、杂环基、羟基、羧基、硝基、氧代基等一种或多种基团；R3是烷基氨基、氨基、羟基等一种或多种基团；环A是5元或6元杂芳环或苯环；m和n各自是1到6的整数；p是1到3的整数，或其盐具有保护神经元、加速神经再生和加速神经突起延伸的活性，因此可用作治疗中枢和外周神经疾病的治疗剂。
• 2- Arylmethylazetidine Carbapenem Derivatives and Preparation Thereof
  申请人：Kim Bong-Jin

  公开号：US20070244089A1

  公开（公告）日：2007-10-18

  A 2-arylmethylazetidine carbapenem derivative of formula (I) or a pharmaceutically acceptable salt thereof exhibits a wide spectrum of antibacterial activities against Gram-positive and Gram-negative bacteria and excellent antibacterial activities against resistant bacteria such as methicillinresistant Staphylococcus aureus (MRSA) and quinolone-resistant strains (QRS).

  式（I）的2-芳基甲基氮杂丙烯基头孢菌素衍生物或其药学上可接受的盐，对革兰氏阳性和革兰氏阴性细菌表现出广谱的抗菌活性，对甲氧西林耐药金黄色葡萄球菌（MRSA）和喹诺酮耐药菌株（QRS）表现出优异的抗菌活性。
• ALKYL ETHER DERIVATIVES OR SALTS THEREOF
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP1437353B1

  公开（公告）日：2007-06-13
• HIGGINS, ROBERT H.;WATSON, MONIQUE R.;FAIRCLOTH, WILLIAM J.;EATON, QUENTI+, J. HETEROCYCL. CHEM., 25,(1988) N 2, 383-387
  作者：HIGGINS, ROBERT H.、WATSON, MONIQUE R.、FAIRCLOTH, WILLIAM J.、EATON, QUENTI+

  DOI：——

  日期：——