4-(cyclopentylamino)-1,2,3,4-tetrahydro-1-naphthalenone | 1106767-58-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-(cyclopentylamino)-1,2,3,4-tetrahydro-1-naphthalenone
• 英文别名: 4-(cyclopentylamino)-3,4-dihydro-2H-naphthalen-1-one
• CAS: 1106767-58-1
• 化学式: C₁₅H₁₉NO
• 分子量: 229.322
• InChiKey: IXTOZCVUGIFDAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(cyclopentylamino)-1,2,3,4-tetrahydro-1-naphthalenone 、 4-甲基苄溴 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 168.0h， 以80%的产率得到4-[cyclopentyl(4-methylbenzyl)amino]-1,2,3,4-tetrahydro-1-naphthalenone
  参考文献：
  名称：

  Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds

  摘要：

  A novel series of amine and amide derivatives of 4-amino-3,4-dihydro-2H-naphthalen-1-one were synthesised. The amine derivatives were evaluated for mast cell stabilising activity in rodent mast cell preparations against the reference compound disodium cromoglycate and found to possess significant activity in vitro. The amide compounds were evaluated in an in vivo murine model for anti-inflammatory activity. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.02.009
• 作为产物：
  描述：

  在 Jones reagent 作用下， 以 丙酮 为溶剂， 以60%的产率得到4-(cyclopentylamino)-1,2,3,4-tetrahydro-1-naphthalenone
  参考文献：
  名称：

  Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds

  摘要：

  A novel series of amine and amide derivatives of 4-amino-3,4-dihydro-2H-naphthalen-1-one were synthesised. The amine derivatives were evaluated for mast cell stabilising activity in rodent mast cell preparations against the reference compound disodium cromoglycate and found to possess significant activity in vitro. The amide compounds were evaluated in an in vivo murine model for anti-inflammatory activity. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.02.009

文献信息

• Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds
  作者：James W. Barlow、John J. Walsh

  DOI：10.1016/j.ejmech.2008.02.009

  日期：2008.12

  A novel series of amine and amide derivatives of 4-amino-3,4-dihydro-2H-naphthalen-1-one were synthesised. The amine derivatives were evaluated for mast cell stabilising activity in rodent mast cell preparations against the reference compound disodium cromoglycate and found to possess significant activity in vitro. The amide compounds were evaluated in an in vivo murine model for anti-inflammatory activity. (C) 2008 Elsevier Masson SAS. All rights reserved.