(1R,2S)-3-methyl-2-morpholino-1-phenylbutan-1-ol | 849599-92-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R,2S)-3-methyl-2-morpholino-1-phenylbutan-1-ol
• 英文别名: (1R,2S)-3-methyl-2-morpholin-4-yl-1-phenylbutan-1-ol
• CAS: 849599-92-4
• 化学式: C₁₅H₂₃NO₂
• 分子量: 249.353
• InChiKey: LOZZOFGNUKEHSW-LSDHHAIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1R,2S)-3-methyl-2-morpholino-1-phenylbutan-1-ol 在 三乙胺 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 9.0h， 生成 (S)-(1R,2S)-3-methyl-2-morpholino-1-phenylbutyl ethanethioate
  参考文献：
  名称：

  New β-amino thiols as efficient catalysts for highly enantioselective alkenylzinc addition to aldehydes

  摘要：

  A series of new optically active beta-amino thiols and thiolacetates prepared from the simple natural amino acid, (S)-(-)-valine, were found to be effective catalysts for the enantioselective addition of alkenylzinc to alclehydes and thereby providing an efficient route for chiral (E)-allylic alcohols with ees of up to >99% in the presence of 7a (1 mol %). (C) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetasy.2004.11.093
• 作为产物：
  描述：

  L-dibenzylvalinal 在 potassium carbonate 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 19.0h， 生成 (1R,2S)-3-methyl-2-morpholino-1-phenylbutan-1-ol
  参考文献：
  名称：

  New β-amino thiols as efficient catalysts for highly enantioselective alkenylzinc addition to aldehydes

  摘要：

  A series of new optically active beta-amino thiols and thiolacetates prepared from the simple natural amino acid, (S)-(-)-valine, were found to be effective catalysts for the enantioselective addition of alkenylzinc to alclehydes and thereby providing an efficient route for chiral (E)-allylic alcohols with ees of up to >99% in the presence of 7a (1 mol %). (C) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetasy.2004.11.093

文献信息

• New β-amino thiols as efficient catalysts for highly enantioselective alkenylzinc addition to aldehydes
  作者：Shi-Liang Tseng、Teng-Kuei Yang

  DOI：10.1016/j.tetasy.2004.11.093

  日期：2005.2

  A series of new optically active beta-amino thiols and thiolacetates prepared from the simple natural amino acid, (S)-(-)-valine, were found to be effective catalysts for the enantioselective addition of alkenylzinc to alclehydes and thereby providing an efficient route for chiral (E)-allylic alcohols with ees of up to >99% in the presence of 7a (1 mol %). (C) 2005 Published by Elsevier Ltd.