6-[4-[4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazin-1-yl]piperidino]hexylamine | 1318249-95-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6-[4-[4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazin-1-yl]piperidino]hexylamine
• 英文别名: 6-[4-[4-[3-(5-Methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazin-1-yl]piperidin-1-yl]hexan-1-amine
• CAS: 1318249-95-4
• 化学式: C₂₉H₅₀N₄O
• 分子量: 470.742
• InChiKey: NOZQSHNNWQCAEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  45
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-[4-[4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazin-1-yl]piperidino]hexylamine 、 4-氯-7-硝基苯并-2-氧杂-1,3-二唑 以 乙醇 为溶剂， 反应 1.5h， 生成 N-[6-[4-[4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazin-1-yl]piperidin-1-yl]hexyl]-4-nitro-2,1,3-benzoxadiazol-7-amine
  参考文献：
  名称：

  Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells

  摘要：

  Fluorescent derivatives of sigma(2) high affinity ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine 1 (PB28) were synthesized. NBD or dansyl fluorescent tags were connected through a 5- or 6-atom linker in two diverse positions of 1 structure. Good sigma(2) affinities were obtained when the fluorescent tag was linked to 5-methoxytetralin nucleus replacing the methyl function. NBD-bearing compound 16 displayed high sigma(2) affinity (K(i) = 10.8 nM) and a optimal fluorescent properties. Its uptake in pancreatic tumor cells was evaluated by flow cytometry, showing that it partially occurs through endocytosis. In proliferating cells, the uptake was higher supporting that sigma(2) receptors are markers of cell proliferation and that the higher the proliferation is, the stronger the antiproliferative effect of sigma(2) agonists is. Colocalization of 16 with subcellular organelles was studied by confocal microscopy: the greatest was in endoplasmic reticulum and lysosomes. Fluorescent sigma(2) ligands show their potential in clarifying the mechanisms of action of sigma(2) receptors.

  DOI：

  10.1021/jm200591t
• 作为产物：
  描述：

  6-溴己腈 在 盐酸 、 lithium aluminium tetrahydride 、 sodium cyanoborohydride 、 三乙胺 、 zinc(II) chloride 作用下， 以 乙醚 、 二氯甲烷 、 水 、 异丙醇 、 丙酮 为溶剂， 反应 57.0h， 生成 6-[4-[4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazin-1-yl]piperidino]hexylamine
  参考文献：
  名称：

  Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells

  摘要：

  Fluorescent derivatives of sigma(2) high affinity ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine 1 (PB28) were synthesized. NBD or dansyl fluorescent tags were connected through a 5- or 6-atom linker in two diverse positions of 1 structure. Good sigma(2) affinities were obtained when the fluorescent tag was linked to 5-methoxytetralin nucleus replacing the methyl function. NBD-bearing compound 16 displayed high sigma(2) affinity (K(i) = 10.8 nM) and a optimal fluorescent properties. Its uptake in pancreatic tumor cells was evaluated by flow cytometry, showing that it partially occurs through endocytosis. In proliferating cells, the uptake was higher supporting that sigma(2) receptors are markers of cell proliferation and that the higher the proliferation is, the stronger the antiproliferative effect of sigma(2) agonists is. Colocalization of 16 with subcellular organelles was studied by confocal microscopy: the greatest was in endoplasmic reticulum and lysosomes. Fluorescent sigma(2) ligands show their potential in clarifying the mechanisms of action of sigma(2) receptors.

  DOI：

  10.1021/jm200591t