1,2,3,4-tetrahydro-benz[g]isoquinoline | 21628-46-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1,2,3,4-tetrahydro-benz[g]isoquinoline
• 英文别名: 1,2,3,4-Tetrahydro-benz[g]isochinolin；1,2,3,4-Tetrahydrobenzo[g]isoquinoline
• CAS: 21628-46-6
• 化学式: C₁₃H₁₃N
• 分子量: 183.253
• InChiKey: YZGSLLPFIVQGHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,2,3,4-tetrahydro-benz[g]isoquinoline 在 potassium nitrososulfonate 、 sodium carbonate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以0.61 g的产率得到3,4-dihydrobenzisoquinoline
  参考文献：
  名称：

  3,4-Dihydrobenz[f]isoquinoline and 3,4-dihydrobenz[g]isoquinoline

  摘要：

  DOI：

  10.1021/jo00240a042
• 作为产物：
  描述：

  2-azaanthracene 在 盐酸 、 tin 作用下， 生成 1,2,3,4-tetrahydro-benz[g]isoquinoline
  参考文献：
  名称：

  v. Braun; Nelles, Chemische Berichte, 1937, vol. 70, p. 1760,1764

  摘要：

  DOI：

文献信息

• Melanin-concentrating hormone antagonist
  申请人：——

  公开号：US20040077628A1

  公开（公告）日：2004-04-22

  A melanin-concentrating hormone antagonist comprising a compound of the formula (I): 1 wherein Ar 1 is a cyclic group which may be substituted; X and Y are the same or different and are a spacer having a main chain of 1 to 6 atoms; Ar is a condensed polycyclic aromatic ring which may be substituted; R 1 and R 2 are the same or different and are hydrogen atom or a hydrocarbon group which may be substituted; or R 1 and R 2 , together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic ring which may be substituted; or R 2 , together with the adjacent nitrogen atom and Y, may form a nitrogen-containing heterocyclic ring which may be substituted; or R 2 , together with the adjacent nitrogen atom, Y and Ar, may form a condensed ring; or a salt thereof is useful as an agent for preventing or treating obesity, etc.

  一种黑色素浓集激素拮抗剂，包括化合物(I)的一种，其中Ar1是一个可以被取代的环状基团；X和Y相同或不同，是具有1至6个原子的主链间隔物；Ar是一个可以被取代的紧凑多环芳香环；R1和R2相同或不同，是氢原子或可以被取代的碳氢基团；或者R1和R2与相邻的氮原子一起可以形成一个可以被取代的含氮杂环；或者R2与相邻的氮原子和Y一起可以形成一个可以被取代的含氮杂环；或者R2与相邻的氮原子、Y和Ar一起可以形成一个紧凑环；或其盐，可用作预防或治疗肥胖等药物。
• METHODS AND COMPOUNDS FOR INHIBITING AMYLOID DEPOSITS
  申请人：Szarek Walter A.

  公开号：US20080227767A1

  公开（公告）日：2008-09-18

  Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.

  本发明提供了在治疗淀粉样变性方面有用的方法和组合物。具体而言，提供了用于抑制、预防和治疗淀粉样沉积的方法和组合物，例如在胰岛中，其中淀粉样沉积是胰岛淀粉样多肽(IAPP)相关的淀粉样沉积或沉积物。本发明的方法涉及向受试者施用抑制IAPP相关淀粉样沉积的治疗化合物。因此，本发明的组合物和方法对于抑制IAPP相关淀粉样变性在发生此类淀粉样沉积的疾病，如糖尿病方面是有用的。
• MELANIN CONCENTRATING HORMONE ANTAGONISTS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1285651A1

  公开（公告）日：2003-02-26

  A melanin-concentrating hormone antagonist comprising a compound of the formula (I): wherein Ar1 is a cyclic group which may be substituted; X and Y are the same or different and are a spacer having a main chain of 1 to 6 atoms; Ar is a condensed polycyclic aromatic ring which may be substituted; R1 and R2 are the same or different and are hydrogen atom or a hydrocarbon group which may be substituted; or R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom, Y and Ar, may form a condensed ring; or a salt thereof is useful as an agent for preventing or treating obesity, etc.

  一种黑色素浓缩激素拮抗剂，由式(I)化合物组成： 其中 Ar1 是可被取代的环状基团； X 和 Y 相同或不同，是具有 1 至 6 个原子主链的间隔物；Ar 是可被取代的缩合多环芳香环；R1 和 R2 相同或不同，是氢原子或可被取代的烃基；或 R1 和 R2 与相邻的氮原子一起可形成可被取代的含氮杂环；或 R2 与相邻的氮原子和 Y 可形成一个可被取代的含氮杂环；或 R2 与相邻的氮原子、Y 和 Ar 可形成一个缩合环；或其盐可用作预防或治疗肥胖症等的药物。
• YOUNG, STEVEN D.;WIGGINS, J. MARK;HUFF, JOEL R., J. ORG. CHEM., 53,(1988) N 5, 1114-1116
  作者：YOUNG, STEVEN D.、WIGGINS, J. MARK、HUFF, JOEL R.

  DOI：——

  日期：——
• NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0869947A1

  公开（公告）日：1998-10-14