21-[4-(2,6-二-1-吡咯烷基-4-嘧啶基)-1-哌嗪基]孕甾-1,4,9[11]-三烯-3,20-二酮马来酸盐 | 153190-29-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 21-[4-(2,6-二-1-吡咯烷基-4-嘧啶基)-1-哌嗪基]孕甾-1,4,9[11]-三烯-3,20-二酮马来酸盐
• 英文名称: U-74389G maleate
• 英文别名: (Z)-but-2-enedioic acid;(8S,10S,13S,14S,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13-dimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one
• CAS: 153190-29-5
• 化学式: C41H54N6O6
• 分子量: 726.9
• InChiKey: ABCSSKWSUJMJCP-WQDFMEOSSA-N

物化性质

• 稳定性/保质期：
  遵照规定使用和储存，则不会分解。

计算性质

• 辛醇/水分配系数(LogP)：
  4.92
• 重原子数：
  53
• 可旋转键数：
  8
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  148
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Compositions comprising a mitofusin inhibitor for promoting cell reprogramming and a use thereof
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US10494611B2

  公开（公告）日：2019-12-03

  The present invention relates to a composition comprising a repressor of mitofusin gene expression, an inhibitor of mitofusin protein activity, or a mixture thereof as an active ingredient for promoting reprogramming a differentiated cell into a pluripotent stem cell, and a use thereof. The composition according to the present invention increases the efficiency of reprogramming as well as reduces the time required for reprogramming to produce pluripotent stem cells. Therefore, the present composition can be beneficially used to develop the production technology of high efficiency pluripotent stem cell and secure a large-scale culture system. Further, the present composition can be beneficially used to maintain pluripotent stem cells and screen the compounds capable of promoting the reprogramming into pluripotent stem cells.

  本发明涉及一种组合物，该组合物包含丝裂蛋白基因表达抑制剂、丝裂蛋白蛋白活性抑制剂或其混合物，作为促进分化细胞重编程为多能干细胞的活性成分，以及其用途。根据本发明的组合物提高了重编程的效率，并缩短了重编程产生多能干细胞所需的时间。因此，本发明组合物可用于开发高效多能干细胞的生产技术和确保大规模培养系统。此外，本组合物还可用于维持多能干细胞，筛选能够促进多能干细胞重编程的化合物。
• COMPOSITIONS COMPRISING A MITOFUSIN INHIBITOR FOR PROMOTING CELL REPROGRAMMING AND A USE THEREOF
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：EP3041928B1

  公开（公告）日：2020-03-25
• [EN] COMPOSITIONS COMPRISING A MITOFUSIN INHIBITOR FOR PROMOTING CELL REPROGRAMMING AND A USE THEREOF<br/>[FR] COMPOSITIONS COMPRENANT UN INHIBITEUR DE MITOFUSINE POUR FAVORISER LA REPROGRAMMATION CELLULAIRE ET UNE UTILISATION CORRESPONDANTE
  申请人：KOREA RES INST OF BIOSCIENCE

  公开号：WO2016080608A1

  公开（公告）日：2016-05-26

  The present invention relates to a composition comprising a repressor of mitofusin gene expression, an inhibitor of mitofusin protein activity, or a mixture thereof as an active ingredient for promoting reprogramming a differentiated cell into a pluripotent stem cell, and a use thereof. The composition according to the present invention increases the efficiency of reprogramming as well as reduces the time required for reprogramming to produce pluripotent stem cells. Therefore, the present composition can be beneficially used to develop the production technology of high efficiency pluripotent stem cell and secure a large-scale culture system. Further, the present composition can be beneficially used to maintain pluripotent stem cells and screen the compounds capable of promoting the reprogramming into pluripotent stem cells.