8-Amino-2H-benzo[b][1,4]thiazin-3(4H)-one | 21762-31-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 8-Amino-2H-benzo[b][1,4]thiazin-3(4H)-one
• 英文别名: 8-amino-4H-1,4-benzothiazin-3-one
• CAS: 21762-31-2
• 化学式: C₈H₈N₂OS
• 分子量: 180.23
• InChiKey: INJNNVXOEQBWKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  80.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-羟基亚甲基环己酮 、 8-Amino-2H-benzo[b][1,4]thiazin-3(4H)-one 生成 8-[(2E)-2-(2-oxocyclohexylidene)hydrazinyl]-4H-1,4-benzothiazin-3-one
  参考文献：
  名称：

  BRUNELLI C.; FRAVOLINI A.; GRANDOLINI G.; STRAPPAGHETTI G., J. HETEROCYCL. CHEM., 1980, 17, NO 1, 199-200

  摘要：

  DOI：

文献信息

• Heteroaryl substituted phenylene derivatives, their preparation and their use as leukotriene receptor antagonists
  申请人：KOWA CO. LTD.

  公开号：EP0799826A1

  公开（公告）日：1997-10-08

  This invention relates to a phenylene derivative represented by the following formula (1) or a salt thereof and also to a medicine containing it as an effective ingredient. wherein R1 represents H or halogen; A represents -CH=CH-, -CH=N-, -N(R2)-, -O- or -S-; W represents -CH=CH- or -CH2O-; X represents -CH2O-, -CH2S-, - CH2N(R3)-, -CH=N-, -COO- or -CONH-; Y represents B1 represents -C(R7)(R8)(CH2)ℓ-, -S(O)m(CH2)n- or -CH=C(R9)-; B2 represents -CH2CH2- or -CH2CH2CH2-; Z1 and Z2 each represents O or S; etc. The phenylene derivative or salt thereof has antileukotrienic action and antihistaminic action and is useful as a medicine such as an asthma preventive or curative.

  本发明涉及以下式（1）所表示的苯基衍生物或其盐，以及含有其作为有效成分的药物。其中，R1表示H或卤素；A表示-CH=CH-，-CH=N-，-N（R2）-，-O或-S-；W表示-CH=CH-或-CH2O-；X表示-CH2O-，-CH2S-，-CH2N（R3）-，-CH=N-，-COO-或-CONH-；Y表示B1表示-C（R7）（R8）（CH2）ℓ-，-S（O）m（CH2）n-或-CH=C（R9）-；B2表示-CH2CH2-或-CH2CH2CH2-；Z1和Z2各表示O或S等。该苯基衍生物或其盐具有抗白三烯作用和抗组胺作用，并且可用作药物，例如哮喘预防或治疗药物。
• HETEROCYCLIDENE-N-(ARYL) ACETAMIDE DERIVATIVE
  申请人：UCHIDA Hideharu

  公开号：US20100016285A1

  公开（公告）日：2010-01-21

  The blow-described formula (I) [Ch. 1] a compound represented by formula (I) (wherein k, m, n, and p each represent 0 to 2; j and q represents 0 or 1; R 1 represents a halogen atom, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, NH 2 , OH, a carboxyl group, an alkanoyl group, CN, NO 2 , or the like; R 2 represents a halogen atom, an amino group, a hydrocarbon group, an aromatic heterocyclic group, an oxo group, or the like; represents an oxygen atom, —NR 3 —, or —S(O)r- (wherein r is an integer of 0 to 2); X 2 represents a methylene group, an oxygen atom, —NR 3 — (wherein R 3 is a hydrogen atom, a hydrocarbon group, or the like), or S(O)r- (wherein r is an integer of 0 to 2); W represents a methylene group, a carbonyl group, or a sulfonyl group; R 7 represents a hydrogen atom, a hydrocarbon group, a heterocyclic group, or the like; R 8 represents a hydrogen atom, a halogen atom, a hydrocarbon group, a heterocyclic group, the broken line in the ring containing X 1 and X 2 represents a condensation of two rings; cycle moiety represents a five- or six-membered aryl ring or heteroaryl ring; and the solid line and the broken line between L 1 and L 2 are a single bond or double bond, and the wavy line represents an E-isomer or a Z-isomer), a salt thereof, or solvates thereof, and a pharmaceutical composition containing the compound as an active ingredient.

  以下是所描述的公式(I)[Ch. 1]的化合物，由公式(I)表示（其中k、m、n和p各自表示0到2；j和q表示0或1；R1表示卤素原子、碳氢基团、杂环基团、烷氧基、烷氧羰基基团、NH2、OH、羧基、烷酰基、CN、NO2或类似物；R2表示卤素原子、氨基基团、碳氢基团、芳香杂环基团、氧代基团或类似物；表示氧原子、-NR3-或-S（O）r-（其中r为0至2的整数）；X2表示亚甲基基团、氧原子、-NR3-（其中R3为氢原子、碳氢基团或类似物）或S（O）r-（其中r为0至2的整数）；W表示亚甲基基团、羰基基团或磺酰基基团；R7表示氢原子、碳氢基团、杂环基团或类似物；R8表示氢原子、卤素原子、碳氢基团、杂环基团，环中的X1和X2之间的断线表示两个环的缩合；环基表示五元或六元芳基环或杂芳基环；实线和L1和L2之间的断线是单键或双键，波浪线表示E-异构体或Z-异构体），其盐或溶剂化物，以及含有该化合物作为活性成分的药物组成物。
• Alkanolaminoxy derivatives of 3,4-dihydro-2H-1,4-benzothiazin-3-one, their production process, and their pharmaceutical use
  申请人：MEDIOLANUM FARMACEUTICI s.r.l.

  公开号：EP0106816A2

  公开（公告）日：1984-04-25

  Object of the invention is a class of new organic compounds derived from 1,4-benzothiazine through substitution of an hydrogen atom in position 6, 7 or 8 by an oxypropanolammine radical monosubstituted in N and furthermore a series of new phenyl derivatives of 1,4-benzothiazine, obtained as intermediate in the synthesis of oxypropanolammine derivatives, and process for obtained the new compounds in form suitable for the preparation of pharmaceutical compositions having antihypertensive, vasodilating and antiarrhythmic activity.

  本发明的目的是一类新的有机化合物，由 1,4-苯并噻嗪通过 6、7 或 8 位上的氢原子被 N 单取代的氧丙醇胺基所取代而得到，此外还有一系列新的 1,4-苯并噻嗪苯基衍生物，这些衍生物在合成氧丙醇胺衍生物的过程中作为中间体而得到，以及获得这些新化合物的工艺，这些新化合物的形式适合于制备具有抗高血压、血管扩张和抗心律失常活性的药物组合物。
• HETEROCYCLIDENE-N-(ARYL)ACETAMIDE DERIVATIVE
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP2128157A1

  公开（公告）日：2009-12-02

  The blow-described formula (I): [Ch. 1] a compound represented by formula (I) : (wherein k, m, n, and p each represent 0 to 2; j and q represents 0 or 1; R1 represents a halogen atom, a hydrocarbon group, a heterocyclic group, an alkoxy group, an alkoxycarbonyl group, NH2, OH, a carboxyl group, an alkanoyl group, CN, NO2, or the like; R2 represents a halogen atom, an amino group, a hydrocarbon group, an aromatic heterocyclic group, an oxo group, or the like; X1 represents an oxygen atom, -NR3-, or -S(O)r- (wherein r is an integer of 0 to 2); X2 represents a methylene group, an oxygen atom, -NR3- (wherein R3 is a hydrogen atom, a hydrocarbon group, or the like), or -S(O)r- (wherein r is an integer of 0 to 2); W represents a methylene group, a carbonyl group, or a sulfonyl group; R7 represents a hydrogen atom, a hydrocarbon group, a heterocyclic group, or the like; R8 represents a hydrogen atom, a halogen atom, a hydrocarbon group, a heterocyclic group, the broken line in the ring containing X1 and X2 represents a condensation of two rings; cycle moiety represents a five- or six-memebered aryl ring or heteroaryl ring; and the solid line and the broken line between L1 and L2 are a single bond or double bond, and the wavy line represents an E-isomer or a Z-isomer), a salt thereof, or solvates thereof, and a pharmaceutical composition containing the compound as an active ingredient.

  吹气式（I）： [1] 式 (I) 所代表的化合物： (其中 k、m、n 和 p 分别代表 0 至 2；j 和 q 代表 0 或 1；R1 代表卤素原子、烃基、杂环基、烷氧基、烷氧羰基、NH2、OH、羧基、烷酰基、CN、NO2 或类似物；X1 代表氧原子、-NR3- 或 -S(O)r- （其中 r 为 0 至 2 的整数）； X2 代表亚甲基、氧原子、-NR3- （其中 R3 为氢原子、烃基或类似基团）或 -S(O)r- （其中 r 为 0 至 2 的整数）；W 代表亚甲基、羰基或磺酰基； R7 代表氢原子、烃基、杂环基或类似基团； R8 代表氢原子、卤素原子、烃基、杂环基；L1和L2之间的实线和断线为单键或双键，波浪线代表E-异构体或Z-异构体）、其盐或其溶物，以及含有该化合物作为活性成分的药物组合物。
• CECCHETTI, V.;DOMINICI, S.;FRAVOLINI, A.;SCHIAFFELLA, F., EUR. J. MED. CHEM., 1984, 19, N 1, 29-35
  作者：CECCHETTI, V.、DOMINICI, S.、FRAVOLINI, A.、SCHIAFFELLA, F.

  DOI：——

  日期：——