24-羟基维他命D2 | 58050-56-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 24-羟基维他命D2
• 英文名称: 24-Hydroxyvitamin D2
• 英文别名: (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R)-5-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
• CAS: 58050-56-9
• 化学式: C₂₈H₄₄O₂
• 分子量: 412.6
• InChiKey: HVAVRRBYXYEBNC-RKULPTJNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (22e)-5,7,22-Ergostatriene-3beta,24-diol 、 苯 、 水 、 在 氮气 、 乙醇 、 silica gel 作用下， 以 乙醚 为溶剂， 反应 18.0h， 以to yield 0.55 g (55%) of (8)的产率得到24-羟基维他命D2
  参考文献：
  名称：

  Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2

  摘要：

  1.alpha.,24（S）-二羟基维生素D.sub.2是一种有用的药物成分，可用于治疗钙代谢紊乱和各种皮肤疾病。本发明还包括制备合成1.alpha.，24（S）-二羟基维生素D.sub.2，其从麦角固醇开始，在六个步骤中转化为24-羟基麦角固醇。24-羟基麦角固醇经过辐射和热转化成24-羟基维生素D.sub.2，再在六个步骤中转化为1.alpha.，24（S）-二羟基维生素D.sub.2。这些合成还产生了新的中间体。

  公开号：

  US05789397A1

文献信息

• 24-Hydroxyvitamin D, analogs and uses thereof
  申请人：Bone Care International, Inc

  公开号：US20010002397A1

  公开（公告）日：2001-05-31

  The invention provides 24-hydroxyvitamin D compounds and methods for their use in the treatment and prophylaxis of hyperparathyroidism and hyperproliferative diseases, and in the modulation of the immune and inflammatory responses as well as the treatment of bone depletive disorders.

  该发明提供了24-羟基维生素D化合物及其在治疗和预防甲状旁腺功能亢进症和增生性疾病，以及调节免疫和炎症反应以及治疗骨质疏松性疾病方面的用途的方法。
• Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
  申请人：Bone Care International, Inc.

  公开号：US20020032179A1

  公开（公告）日：2002-03-14

  A method of inhibiting the hyperproliferation of malignant or neoplastic cells, comprising treating the cells with an antiproliferative amount of 1&agr;,24(S)-dihydroxyvitamin D 2 . The method also includes the co-administration of cyotoxic angents with the 1&agr;,24(S)-dihydroxyvitamin D 2 .

  一种抑制恶性或肿瘤细胞过度增殖的方法，包括使用抗增殖剂量的1α,24（S）-双羟基维生素D2治疗细胞。该方法还包括与1α,24（S）-双羟基维生素D2联合使用细胞毒性药剂。
• Methods for preparation and use of 1.alpha.,24(S)-dihydroxy vitamin D.sub.2
  申请人：Bone Care International, Inc.

  公开号：US05786348A1

  公开（公告）日：1998-07-28

  1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.

  1.alpha.,24(S)-二羟基维生素D2是一种有用的药物组分，可用于治疗钙代谢紊乱和各种皮肤疾病。该发明还包括从麦角固醇开始制备合成1.alpha.，24(S)-二羟基维生素D2的方法，经过六个步骤将其转化为24-羟基麦角固醇。24-羟基麦角固醇经过辐射和热转化成24-羟基维生素D2，经过六个步骤将其转化为1.alpha.，24(S)-二羟基维生素D2。该合成还产生了新颖的中间体。
• Methods for preparation and use of 1&agr;,24(S)-dihydroxy vitamin D2
  申请人：Bone Care International, Inc.

  公开号：US06251883B1

  公开（公告）日：2001-06-26

  1&agr;,24(S)-Dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D2. The syntheses also produced novel intermediates.

  1&agr;,24(S)-二羟基维生素D2是一种有用的药物组合物活性成分，可用于治疗钙代谢紊乱和各种皮肤疾病。该发明还包括从麦角固醇开始制备合成1&agr;,24(S)-二羟基维生素D2，经过六个步骤转化为24-羟基麦角固醇。24-羟基麦角固醇经过辐射和热转化成24-羟基维生素D2，经过六个步骤转化为1&agr;,24(S)-二羟基维生素D2。合成也产生了新的中间体。
• Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2
  申请人：Bone Care International, Inc.

  公开号：US05789397A1

  公开（公告）日：1998-08-04

  1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.

  1.alpha.,24（S）-二羟基维生素D.sub.2是一种有用的药物成分，可用于治疗钙代谢紊乱和各种皮肤疾病。本发明还包括制备合成1.alpha.，24（S）-二羟基维生素D.sub.2，其从麦角固醇开始，在六个步骤中转化为24-羟基麦角固醇。24-羟基麦角固醇经过辐射和热转化成24-羟基维生素D.sub.2，再在六个步骤中转化为1.alpha.，24（S）-二羟基维生素D.sub.2。这些合成还产生了新的中间体。