3-methylascorbic acid | 13443-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 3-methylascorbic acid
• 英文别名: 5-(1,2-dihydroxy-ethyl)-3-hydroxy-4-methoxy-5H-furan-2-one；Ascorbinsaeure-methylester-(3)；3-O-Methylascorbinsaeure；2-(1,2-dihydroxyethyl)-4-hydroxy-3-methoxy-2H-furan-5-one
• CAS: 13443-57-7；139164-18-4
• 化学式: C₇H₁₀O₆
• 分子量: 190.153
• InChiKey: HFSCYDMAVALOIA-UHFFFAOYSA-N

物化性质

• 熔点：
  120-122 °C
• 沸点：
  569.3±50.0 °C(Predicted)
• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 海关编码：
  2932209090

反应信息

• 作为反应物：
  描述：

  3-methylascorbic acid 、 hexaaquairon(III) perchlorate 在 lithium perchlorate 作用下， 以 高氯酸 为溶剂， 生成
  参考文献：
  名称：

  Sisley; Jordan, Inorganic Chemistry, 1992, vol. 31, # 11, p. 2137 - 2143

  摘要：

  DOI：

文献信息

• Method for Preparing Crystalline 3-0-Alkyl-Ascorbic Acid
  申请人：Park Sung-Ryoung

  公开号：US20100048919A1

  公开（公告）日：2010-02-25

  The present invention relates to a method for preparing 3-O-substituted ascorbic acid derivatives represented by formula 1, in which 5,6-O-isopropylidene ascorbic acid is reacted with a halide in an organic solvent in the presence of the anion exchange resin absorbed with multi-iodine anions and then deprotected. The method of the present invention has an advantage of providing a target compound with high purity and high yield by finishing the reaction within a short period of time at room temperature.

  本发明涉及一种制备由式1表示的3-O-取代抗坏血酸衍生物的方法，其中在有机溶剂中，将5,6-O-异丙基缩醛抗坏血酸与卤代物在吸附有多碘阴离子的阴离子交换树脂存在下反应，然后去保护基。本发明的方法具有在室温下短时间内完成反应，并提供高纯度和高产率目标化合物的优点。
• Hair dye
  申请人：FUJIFILM Corporation

  公开号：EP1889603A2

  公开（公告）日：2008-02-20

  A hair dye comprising, together or separately, (a) a carboxylic acid silver salt and/or a sulfonic acid silver salt, and (b) a reductone, e.g., reductones of the following formula (I) wherein R represents hydrogen atom or hydroxyl group; and p represents an integer of 1 to 4. There is provided a hair dye having superior hair dyeing property and hair dyeing reproducibility, with superior toughness of dyed hair condition against shampoo, conditioner or light and causing reduced damage to hair.

  一种染发剂，共同或分别包含(a)羧酸银盐和/或磺酸银盐，和(b)还原酮，例如下式(I)的还原酮，其中 R 代表氢原子或羟基；p 代表 1 至 4 的整数。 提供了一种染发剂，具有优异的染发性能和染发重现性，染色后的头发对洗发水、护发素或光线具有优异的韧性，并可减少对头发的损伤。
• Ascorbic acid conjugates
  申请人：Stevens Jan Frederik

  公开号：US20090104705A1

  公开（公告）日：2009-04-23

  Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F 2 -isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. Disclosed herein are new marker compounds, including ascorbylated 4-hydroxy-2-nonenal, that are useful as biomarkers of oxidative stress.
• ASCORBATE FORMULATIONS AND METHODS OF USE AS CONTRAST AGENTS
  申请人：Duke University

  公开号：US20170189561A1

  公开（公告）日：2017-07-06

  A sterile aqueous composition suitable for use as an MRI contrast agent includes 100 to 600 mM ascorbate; and 100-600 mM sodium, meglumine, or a combination thereof. The composition preferably has an osmolarity of 200 to 1400 mOsm/L.
• Contrast Agents for Magnetic Resonance Imaging
  申请人：Duke University

  公开号：US20170189559A1

  公开（公告）日：2017-07-06

  Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (MRI) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an MRI image-enhancing amount; and then generating, by MRI of the subject, an image of the body or body region. The ascorbate or pharmaceutically acceptable salt thereof enhances the MRI image.