3,3-二氯-2-甲基-1-丙烯 | 22227-75-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 中文名称: 3,3-二氯-2-甲基-1-丙烯
• 英文名称: 3,3-dichloro-2-methyl-propene
• 英文别名: 3,3-Dichlor-2-methyl-propen；3,3-dichloro-2-methyl-1-propene；3,3-dichloro-2-methylpropene；methallyl dichloride；1,1-Dichlor-2-methyl-propen-(2)；3,3-Dichlor-2-methyl-propen-(1)；Propene, 3,3-dichloro-2-methyl-；3,3-dichloro-2-methylprop-1-ene
• CAS: 22227-75-4
• 化学式: C₄H₆Cl₂
• 分子量: 124.998
• InChiKey: IBOBCGSJCSKTKP-UHFFFAOYSA-N

物化性质

• 熔点：
  -27.02°C (estimate)
• 沸点：
  118.18°C (rough estimate)
• 密度：
  1.1360
• 保留指数：
  726

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903299090

反应信息

• 作为反应物：
  描述：

  3,3-二氯-2-甲基-1-丙烯 在 水 、 calcium carbonate 作用下， 生成 3-chloro-2-methylpropenol
  参考文献：
  名称：

  Tischtschenko, Zhurnal Obshchei Khimii, 1938, vol. 8, p. 1242

  摘要：

  DOI：
• 作为产物：
  描述：

  1-bromo-2,3-dichloro-2-methyl-propane 在 氢氧化钾 作用下， 生成 3,3-二氯-2-甲基-1-丙烯
  参考文献：
  名称：

  Freidlina,R.Kh. et al., Doklady Chemistry, 1961, vol. 137, p. 292 - 295

  摘要：

  DOI：

文献信息

• Mitotic kinesin inhibitors
  申请人：Coleman J. Paul

  公开号：US20050038074A1

  公开（公告）日：2005-02-17

  The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

  本发明涉及对治疗细胞增殖性疾病、治疗与KSP动力蛋白活性相关的疾病以及抑制KSP动力蛋白的二氢吡咯化合物。该发明还涉及包含这些化合物的组合物，以及利用它们治疗哺乳动物癌症的方法。
• NOVEL AMPHIPHILIC COMPOUND HAVING DENDRONIC HYDROPHOBIC GROUP AND APPLICATION THEREOF
  申请人：Industry-University Cooperation Foundation Hanyang University Erica Campus

  公开号：US20200247836A1

  公开（公告）日：2020-08-06

  The present invention relates to an amphiphilic compound having a dendronic hydrophobic group, a method for preparing the same, and a method for extraction, solubilization, stabilization, or crystallization of a membrane protein by using the same. The use of the compound according to the present invention leads to an excellent membrane protein solubilization effect and a stable storage of a membrane protein in an aqueous solution for a long time, and thus can be utilized for functional analysis and structural analysis of the membrane protein. Especially, the amphiphilic compound having a dendronic hydrophobic group showed very remarkable characteristics in the visualization of protein composites through an electronic microscope. The membrane protein structural and functional analysis is one of the fields of greatest interest in current biology and chemistry, and more than half of the new drugs that are currently being developed are targeted at membrane proteins, and thus the amphiphilic compound of the present invention can be applied to membrane protein structure studies closely related to the development of new drugs.

  本发明涉及具有树状疏水基团的两性分子化合物，以及制备该化合物的方法，以及利用该化合物进行膜蛋白的提取、溶解、稳定化或结晶化的方法。根据本发明的化合物的使用导致出色的膜蛋白溶解效果，并使膜蛋白在水溶液中稳定存储较长时间，因此可用于膜蛋白的功能分析和结构分析。特别是，具有树状疏水基团的两性分子化合物在电子显微镜下显示出非常显著的蛋白质复合物可视化特征。膜蛋白的结构和功能分析是当前生物学和化学领域最感兴趣的领域之一，目前正在开发的新药物中超过一半是针对膜蛋白的，因此本发明的两性分子化合物可应用于与新药物开发密切相关的膜蛋白结构研究。
• Polyether polyol dendron conjugates with effector molecules for biological targeting
  申请人：mivenion GmbH

  公开号：EP2100621A1

  公开（公告）日：2009-09-16

  Subject of the present invention are polyether polyol dendron conjugates comprising a specific polyether polyol dendron moiety, at least one certain fluorescent effector molecule (E). Such polyether polyol dendron conjugates may be used for diagnostic and therapeutic purposes, whereby the optical properties of the at least one certain fluorescent effector molecule are enhanced due to the attachment to the polyether polyol dendron conjugate.

  本发明的主题是聚醚聚醇树枝共轭物，其中包括特定的聚醚聚醇树枝基团和至少一种特定荧光效应分子（E）。这些聚醚聚醇树枝共轭物可用于诊断和治疗目的，由于与聚醚聚醇树枝共轭物的连接，至少一种特定荧光效应分子的光学性能得到增强。
• Substituted 2-propenyl derivatives of pyridine
  申请人：Uniroyal Chemical Company, Inc.

  公开号：US04950671A1

  公开（公告）日：1990-08-21

  A heterocyclic compound having the structural formula ##STR1## where R is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.6 cycloalkyl, trifluoromethyl, phenyl, substituted phenyl, phenoxy, substituted phenoxy, benzyl or substituted benzyl; and R.sup.1 is at least a partially saturated monocyclic or bicyclic heterocycle of nitrogen which may be substituted with lower alkyl and physiologically acceptable salts thereof is disclosed. A process for forming this compound which involves the reaction of an amine of the formula HR.sup.1 where R.sup.1 has the meanings given above with a substituted 2-propenyl halide having the structural formula ##STR2## where R has the meanings given above; and X is a halogen atom is described. The invention embodies the above-mentioned novel 2-propenyl halide utilized as an intermediate in the formation of the heterocyclic compound of this invention. A method ofcontrolling phytopathogenic fungi by applying a fungicidally effective amount of the heterocyclic compound of the present invention to the locus under attack by said fungi is also taught. Finally, a fungicidally composition comprising the heterocyclic compound of the present invention and a suitable carrier therefor is set forth.

  本发明揭示了一种杂环化合物，其结构式为##STR1##其中R为C.sub.1-C.sub.8烷基，C.sub.3-C.sub.6环烷基，三氟甲基，苯基，取代苯基，苯氧基，取代苯氧基，苄基或取代苄基；R.sup.1至少为部分饱和的氮杂环的单环或双环，该氮杂环可以用较低的烷基和生理上可接受的盐取代。本发明还揭示了一种制备该化合物的方法，该方法涉及将具有上述给定含义的R.sup.1的胺与具有结构式##STR2##的取代2-丙烯基卤化物反应，其中R具有上述给定含义；X为卤素原子。本发明体现了上述新型2-丙烯基卤化物，其作为本发明中杂环化合物制备中间体的用途。本发明还教授了一种通过将本发明中的杂环化合物以对抗该真菌的攻击点处的有效杀菌量的方式进行控制植物病原真菌的方法。最后，本发明还提供了一种包含本发明中的杂环化合物和适当载体的真菌杀菌组合物。
• [EN] MITOTIC KINESIN INHIBITORS<br/>[FR] INHIBITEURS DE LA KINESINE MITOTIQUE
  申请人：MERCK & CO INC

  公开号：WO2005019206A1

  公开（公告）日：2005-03-03

  The present invention relates to dihydropyrrole compounds of Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

  本发明涉及式(I)的二氢吡咯化合物，其对治疗细胞增殖性疾病、治疗与KSP动力蛋白活性相关的疾病以及抑制KSP动力蛋白具有用途。本发明还涉及包含这些化合物的组合物以及使用它们治疗哺乳动物癌症的方法。