tetrahydropterin-6-carboxylic acid | 7449-02-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: tetrahydropterin-6-carboxylic acid
• 英文别名: 6-carboxytetrahydropterin；6-carboxy-5,6,7,8-tetrahydropterin；6-carboxy-5,6,7,8-tetrahydropretin；2-amino-4-oxo-3,4,5,6,7,8-hexahydro-pteridine-6-carboxylic acid；5,6,7,8-Tetrahydropterin-6-carboxylic acid；2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridine-6-carboxylic acid
• CAS: 7449-02-7
• 化学式: C₇H₉N₅O₃
• 分子量: 211.18
• InChiKey: QSIYONWVWDSRRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  129
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  蝶呤-6-羧酸 在 platinum(IV) oxide 氢气 作用下， 以 三氟乙酸 为溶剂， 反应 1.0h， 生成 tetrahydropterin-6-carboxylic acid
  参考文献：
  名称：

  用双电极检测器通过液相色谱/电化学法测定生物样品中的蝶呤。

  摘要：

  DOI：

  10.1021/ac00260a004

文献信息

• Optimized microbial cells for production of melatonin and other compounds
  申请人：DANMARKS TEKNISKE UNIVERSITET

  公开号：US10851365B2

  公开（公告）日：2020-12-01

  Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acids, vectors and methods useful for preparing and using such cells. In specific aspects, the present invention relates to monooxygenases, e.g., amino acid hydroxylases, with a modified cofactor-dependency, and to enzyme variants and microbial cells providing for an improved supply of cofactors.

  本文描述了包含生物合成途径的重组微生物宿主细胞及其在生产氧化产物和下游产物（如褪黑素和相关化合物）中的用途，以及酶变体、核酸、载体和制备及使用此类细胞的方法。在具体方面，本发明涉及具有改进的辅助因子依赖性的单加氧酶，例如氨基酸羟化酶，以及提供改进的辅助因子供应的酶变体和微生物细胞。
• Methods and microorganisms for producing flavors and fragrance chemicals
  申请人：ARDRA INC.

  公开号：US11060079B2

  公开（公告）日：2021-07-13

  The present disclosure relates to biosynthetic pathways for producing flavor and fragrance chemicals, such as green notes including trans-2-unsaturated aldehydes and lactones. The present disclosure provides methods for producing trans-2-unsaturated aldehydes, delta-lactones, and gamma-lactones. The present disclosure provides pathways for the preparation of trans-2-unsaturated aldehydes, delta-lactones, and gamma-lactones by reacting aldehydes in the presence of aldolases.

  本公开涉及生产香精香料化学品的生物合成途径，例如包括反式-2-不饱和醛和内酯在内的绿色香料。本公开提供了生产反式-2-不饱和醛、δ-内酯和γ-内酯的方法。本公开提供了在醛酶存在下通过醛反应制备反式-2-不饱和醛、δ-内酯和γ-内酯的途径。
• METHODS AND MICROORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL
  申请人：The Governing Council of the University of Toronto

  公开号：EP3325608B1

  公开（公告）日：2021-11-24
• OPTIMIZED MICROBIAL CELLS FOR PRODUCTION OF MELATONIN AND OTHER COMPOUNDS
  申请人：Danmarks Tekniske Universitet

  公开号：EP3436595A1

  公开（公告）日：2019-02-06
• Optimized Microbial Cells for Production of Melatonin and Other Compounds
  申请人：DANMARKS TEKNISKE UNIVERSITET

  公开号：US20190119663A1

  公开（公告）日：2019-04-25

  Described herein are recombinant microbial host cells comprising biosynthetic pathways and their use in producing oxidation products and downstream products, e.g., melatonin and related compounds, as well as enzyme variants, nucleic acids, vectors and methods useful for preparing and using such cells. In specific aspects, the present invention relates to monooxygenases, e.g., amino acid hydroxylases, with a modified cofactor-dependency, and to enzyme variants and microbial cells providing for an improved supply of cofactors.