4-chloro-1-N,1-N-diethylbenzene-1,3-diamine | 1093657-09-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-chloro-1-N,1-N-diethylbenzene-1,3-diamine
• CAS: 1093657-09-0
• 化学式: C₁₀H₁₅ClN₂
• 分子量: 198.695
• InChiKey: FJAFIQFHZMPINK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chloro-1-N,1-N-diethylbenzene-1,3-diamine 、 3,4-二甲氧基苯磺酰氯 在 吡啶 作用下， 生成 N-(2-chloro-5-(diethylamino)phenyl)-3,4-dimethoxybenzenesulfonamide
  参考文献：
  名称：

  N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists

  摘要：

  A series of dual OX(1)R/OX(2)R orexin antagonists was prepared based on a N-glycine-sulfonamide core. SAR studies of a screening hit led to compounds with low nanomolar affinity for both receptors and good oral bioavailability. One of these compounds, 47, has demonstrated in vivo activity in rats following oral administration. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.09.079

文献信息

• Materials for high density optical recording media
  申请人：Gigastorage Corporation

  公开号：US20040225115A1

  公开（公告）日：2004-11-11

  Materials for optical recording media are disclosed. Specifically, the materials are metal chelate compounds of azo dyes, which are formed from sulfamoylated m-diaminobenzene compounds and benzene ring-containing azo compounds. Further, the invention provides an optical recording medium, characterized in that said metal chelate compounds of azo dyes are employed onto the optical recording medium to form a recording layer. The invention also discloses a process for the production of an optical recording medium.

  本发明公开了用于光学记录介质的材料。具体来说，这些材料是由磺胺基化的m-二氨基苯化合物和含苯环的偶氮染料形成的金属螯合物。此外，该发明提供了一种光学记录介质，其特征在于所述金属螯合物的偶氮染料被应用于光学记录介质以形成记录层。该发明还公开了一种生产光学记录介质的方法。
• Dyes for high density optical recording media
  申请人：Gigastorage Corporation

  公开号：EP1583090A2

  公开（公告）日：2005-10-05

  Materials for optical recording media are disclosed. Specifically, the materials are metal chelate compounds of azo dyes, which are formed from sulfamoylated m-diaminobenzene compounds and benzene ring-containing azo compounds. Further, the invention provides an optical recording medium, characterized in that said metal chelate compounds of azo dyes are employed onto the optical recording medium to form a recording layer. The invention also discloses a process for the production of an optical recording medium.

  本发明公开了用于光学记录介质的材料。具体地说，这些材料是偶氮染料的金属螯合物，由氨基磺酰化间二氨基苯化合物和含苯环的偶氮化合物形成。此外，本发明还提供了一种光学记录介质，其特征在于在光学记录介质上采用所述偶氮染料的金属螯合物形成记录层。本发明还公开了一种光学记录介质的生产工艺。
• US7468201B2
  申请人：——

  公开号：US7468201B2

  公开（公告）日：2008-12-23
• N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists
  作者：Hamed Aissaoui、Ralf Koberstein、Cornelia Zumbrunn、John Gatfield、Catherine Brisbare-Roch、Francois Jenck、Alexander Treiber、Christoph Boss

  DOI：10.1016/j.bmcl.2008.09.079

  日期：2008.11

  A series of dual OX(1)R/OX(2)R orexin antagonists was prepared based on a N-glycine-sulfonamide core. SAR studies of a screening hit led to compounds with low nanomolar affinity for both receptors and good oral bioavailability. One of these compounds, 47, has demonstrated in vivo activity in rats following oral administration. (C) 2008 Elsevier Ltd. All rights reserved.