4-methylhexan-3-amine | 35399-83-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-methylhexan-3-amine
• CAS: 35399-83-8
• 化学式: C₇H₁₇N
• 分子量: 115.219
• InChiKey: MDNNVKMUIHATNR-UHFFFAOYSA-N

物化性质

• 沸点：
  133.2±8.0 °C(Predicted)
• 密度：
  0.775±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  氯甲酸乙酯 、 4-methylhexan-3-amine 在 三乙胺 作用下， 以 乙醚 为溶剂， 生成 4-N-Carbaethoxyamino-3-methyl-hexan
  参考文献：
  名称：

  Carbethoxynitrene. Stereochemistry of the intermolecular singlet carbon-hydrogen insertion

  摘要：

  DOI：

  10.1021/ja01046a029

文献信息

• NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20160168139A1

  公开（公告）日：2016-06-16

  There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z 2 represents CH or the like; Z 1 represents CR 6 or the like; R 6 represents a hydrogen atom or the like; X 1 represents CHR 7 or the like; R 7 represents a hydrogen atom or the like; X 2 represents CH 2 or the like; R 1 and R 2 are the same as or different from each other, and each of R 1 and R 2 represents a hydrogen atom or the like; R 3 , R 4 , and R 5 are the same as or different from each other, and each of R 3 , R 4 , and R 5 represents a hydrogen atom, NR a R b , or the like; and each of R a and R b represents a hydrogen atom, a C 1-8 alkyl group which may have a substituent, or the like.)

  提供一种由通用式[1A]表示的吗啉衍生物或其盐。 （在该式中，环A代表由通用式[I]表示的环；*代表连接位置；Z 2 代表CH或类似物；Z 1 代表CR 6 或类似物；R 6 代表氢原子或类似物；X 1 代表CHR 7 或类似物；R 7 代表氢原子或类似物；X 2 代表CH 2 或类似物；R 1 和R 2 相同或不同，且R 1 和R 2 中的每一个代表氢原子或类似物；R 3 ，R 4 和R 5 相同或不同，且R 3 ，R 4 和R 5 中的每一个代表氢原子，NR a R b 或类似物；R a 和R b 中的每一个代表氢原子，可能具有取代基的C 1-8 烷基基团，或类似物。）
• [EN] BIARYL INHIBITORS OF THE SODIUM CHANNEL<br/>[FR] INHIBITEURS BIARYLE DU CANAL SODIQUE
  申请人：ZALICUS PHARMACEUTICALS LTD

  公开号：WO2013131018A1

  公开（公告）日：2013-09-06

  The invention relates to compounds useful in treating conditions associated with voltage- gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns biaryl derivatives (e.g., compounds according to any of Formulas (I)-(XII) or Compounds (l)-(372) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotropic lateral sclerosis, glaucoma, ischaemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.

  该发明涉及与电压门控离子通道功能相关的化合物，特别是与钠通道活性相关的病症。更具体地说，该发明涉及联萘衍生物（例如，根据表1的任一公式（I）-（XII）或化合物（l）-（372）的化合物），这些化合物可用于治疗癫痫、癌症、疼痛、偏头痛、帕金森病、情绪障碍、精神分裂症、精神病、耳鸣、肌萎缩性侧索硬化、青光眼、缺血、痉挛性障碍、强迫症、不安腿综合征和抽动症等病症的治疗。
• Process for Preparing 5,7 Diaminopyrazolo [1,5-a] Pyrimidine Compounds
  申请人：Liotta Dennis C.

  公开号：US20120041198A1

  公开（公告）日：2012-02-16

  Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-α]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected 5-halo-7-aminopyrazolo[1,5-α]pyrimidine compound in solvent system comprising water and one or more organic solvents, optionally in the presence of an exogenous base.

  制备特定5,7-二氨基吡唑并[1,5-α]嘧啶化合物的方法包括在溶剂体系中将一种初级或次级胺和受保护的5-卤代-7-氨基吡唑并[1,5-α]嘧啶化合物反应，所述溶剂体系包括水和一个或多个有机溶剂，可选地在外源碱的存在下。
• METHOD FOR PRODUCING UNSATURATED ETHER COMPOUND
  申请人：Kyowa Hakko Chemical Co., Ltd.

  公开号：EP1876163A1

  公开（公告）日：2008-01-09

  The present invention provides a method for producing an unsaturated ether compound represented by general formula (2) below, the method comprising reacting an acetal represented by general formula (1) below in the presence of an aliphatic or aromatic sulfonic acid and an organic base having a total carbon number of 3 to 7. (In the formulae, R1, R2, and R3 may be the same or different and each represent substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl, or R1 and R2 form cycloalkyl together with the adjacent carbon atom.)

  本发明提供了一种生产下式(2)所代表的不饱和醚化合物的方法，该方法包括使下式(1)所代表的缩醛在脂肪族或芳香族磺酸和总碳数为3至7的有机碱存在下进行反应。(式中，R1、R2 和 R3 可以相同或不同，各自代表取代或未取代的烷基、取代或未取代的芳基、取代或未取代的芳烷基，或 R1 和 R2 与相邻碳原子一起形成环烷基)。
• Synthesis of disilanylamines through transamination
  申请人：Dow Silicones Corporation

  公开号：US10858378B2

  公开（公告）日：2020-12-08

  The present invention provides processes for preparing silanylamines, such as disilanylamines and polysilanylamines, and compositions comprising the silanylamines. In one embodiment, the present invention provides processes for preparing a silanylamine compound, the processes comprising reacting a starting compound of general formula RR1N—(SixH2x+1) with an amine compound of general formula R2R3NH to produce the silanylamine compound of general formula R2mR3n—N(SixH2+1)3-m-n.

  本发明提供了制备硅烷基胺（如二硅烷基胺和多硅烷基胺）的工艺以及包含硅烷基胺的组合物。在一个实施方案中，本发明提供了制备硅烷胺化合物的工艺，该工艺包括使通式RR1N-(SixH2x+1)的起始化合物与通式R2R3NH的胺化合物反应，生成通式R2mR3n-N(SixH2+1)3-m-n的硅烷胺化合物。