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2-[[5-[5-(4-Methoxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile | 1228958-83-5

中文名称
——
中文别名
——
英文名称
2-[[5-[5-(4-Methoxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile
英文别名
2-[[5-[5-(4-methoxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile
2-[[5-[5-(4-Methoxyphenyl)thiophen-2-yl]thiophen-2-yl]methylidene]propanedinitrile化学式
CAS
1228958-83-5
化学式
C19H12N2OS2
mdl
——
分子量
348.449
InChiKey
AKAXDBSDKCYHOX-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.7
  • 重原子数:
    24
  • 可旋转键数:
    4
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.05
  • 拓扑面积:
    113
  • 氢给体数:
    0
  • 氢受体数:
    5

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为产物:
    参考文献:
    名称:
    Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein
    摘要:
    Aggregations of both amyloid-beta (A beta) and hyper-phosphorylated tau proteins are recognized as key pathological manifestations of Alzheimer's disease (AD). Agents that inhibit both those forms of aggregation show promise as drug candidates. Seventeen oligo heteroaromatic compounds were rapidly synthesized via a one-pot, 3- or 4-component coupling procedure. Evaluations showed that compounds E16 and E18 were the most potent inhibitors of A beta and tau aggregations (E16: IC(50)s = 0.38, 0.29 mu M against A beta, tau, respectively, E18: IC(50)s = 0.55, 0.30 mu M against A beta, tau, respectively). (C) 2014 Elsevier Masson SAS. All rights reserved.
    DOI:
    10.1016/j.ejmech.2014.07.095
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文献信息

  • Synthesis and characterization of novel, thermally stable 2-aryl-5-dicyanovinylthiophenes and 5-aryl-5′-dicyanovinyl-2,2′-bithiophenes as potentially promising non-linear optical materials
    作者:Cyril Herbivo、Alain Comel、G. Kirsch、A. Maurício C. Fonseca、M. Belsley、M. Manuela M. Raposo
    DOI:10.1016/j.dyepig.2010.01.006
    日期:2010.8
    Two series of dicyanovinyl-substituted compounds namely 2-aryl-5-dicyanovinylthiophenes and 5-aryl-5'-dicyanovinyl-2,2'-bithiophenes were synthesized through Knoevenagel condensation of the corresponding 2-aryl-5-formyl-thiophenes and 5-aryl-5'-formyl-2,2'-bithiophene precursors. In contrast, the 2-aryl-5-formyl-thiophenes precursor were prepared through the Vilsmeier Haack Arnold reaction starting from inexpensive and easily available precursors such as acetophenones; this method produced the title compounds in higher yield than that recently reported which involved the Suzuki coupling of functionalized aryl boronic acids with 5-bromo-2-formyl-thiophene. Electrochemical studies and characterization of both the linear and non-linear optical properties and thermal properties indicated that good non-linearity was complemented by exceptional thermal stability for some chromophores, making them potential candidates for several optoelectronic applications such as solvatochromic probes and non-linear optical materials. (C) 2010 Elsevier Ltd. All rights reserved.
  • BLOOD-BRAIN BARRIER PERMEABLE PEPTIDE COMPOSITIONS
    申请人:ICB International, Inc.
    公开号:US20130177568A1
    公开(公告)日:2013-07-11
    Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain bound to one or more constant domains.
  • Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein
    作者:Shinichiro Fuse、Keisuke Matsumura、Yuki Fujita、Hachiro Sugimoto、Takashi Takahashi
    DOI:10.1016/j.ejmech.2014.07.095
    日期:2014.10
    Aggregations of both amyloid-beta (A beta) and hyper-phosphorylated tau proteins are recognized as key pathological manifestations of Alzheimer's disease (AD). Agents that inhibit both those forms of aggregation show promise as drug candidates. Seventeen oligo heteroaromatic compounds were rapidly synthesized via a one-pot, 3- or 4-component coupling procedure. Evaluations showed that compounds E16 and E18 were the most potent inhibitors of A beta and tau aggregations (E16: IC(50)s = 0.38, 0.29 mu M against A beta, tau, respectively, E18: IC(50)s = 0.55, 0.30 mu M against A beta, tau, respectively). (C) 2014 Elsevier Masson SAS. All rights reserved.
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同类化合物

试剂2,2'-Thieno[3,2-b]thiophene-2,5-diylbis-3-thiophenecarboxylicacid 苯并[b]噻吩,3-(2-噻嗯基)- 甲基[2,3'-联噻吩]-5-羧酸甲酯 牛蒡子醇 B 十四氟-Alpha-六噻吩 三丁基(5''-己基-[2,2':5',2''-三联噻吩]-5-基)锡 α-四联噻吩 α-六噻吩 α-五联噻吩 α-七噻吩 α,ω-二己基四噻吩 5,5′-双(3-己基-2-噻吩基)-2,2′-联噻吩 α,ω-二己基六联噻吩 Α-八噻吩 alpha-三联噻吩甲醇 alpha-三联噻吩 [3,3-Bi噻吩]-2,2-二羧醛 [2,2’]-双噻吩-5,5‘-二甲醛 [2,2':5',2''-三联噻吩]-5,5''-二基双[三甲基硅烷] [2,2'-联噻吩]-5-甲醇,5'-(1-丙炔-1-基)- [2,2'-联噻吩]-5-甲酸甲酯 [2,2'-联噻吩]-5-乙酸,a-羟基-5'-(1-炔丙基)-(9CI) C-[2,2-二硫代苯-5-基甲基]胺 5’-己基-2,2’-联噻吩-5-硼酸频哪醇酯 5-辛基-1,3-二(噻吩-2-基)-4H-噻吩并[3,4-c]吡咯-4,6(5H)-二酮 5-苯基-2,2'-联噻吩 5-溴5'-辛基-2,2'-联噻吩 5-溴-5′-己基-2,2′-联噻吩 5-溴-5'-甲酰基-2,2':5'2'-三噻吩 5-溴-3,3'-二己基-2,2'-联噻吩 5-溴-3'-癸基-2,2':5',2''-三联噻吩 5-溴-2,2-双噻吩 5-溴-2,2'-联噻吩-5'-甲醛 5-氯-5'-苯基-2,2'-联噻吩 5-氯-2,2'-联噻吩 5-正辛基-2,2'-并噻吩 5-己基-5'-乙烯基-2,2'-联噻吩 5-己基-2,2-二噻吩 5-全氟己基-5'-溴-2,2'-二噻吩 5-全氟己基-2,2′-联噻吩 5-乙酰基-2,2-噻吩基 5-乙氧基-2,2'-联噻吩 5-丙酰基-2,2-二噻吩 5-{[[2,2'-联噻吩]-5-基}噻吩-2-腈 5-[5-(5-己基噻吩-2-基)噻吩-2-基]噻吩-2-羧酸 5-(羟甲基)-[2,2]-联噻吩 5-(噻吩-2-基)噻吩-2-甲腈 5-(5-甲酰基-3-己基噻吩-2-基)-4-己基噻吩-2-甲醛 5-(5-甲基噻吩-2-基)噻吩-2-甲醛 5-(5-噻吩-2-基噻吩-2-基)噻吩-2-羧酸 5-(5-乙炔基噻吩-2-基)噻吩-2-甲醛