5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>pentanal oxime | 135147-30-7

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: 5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>pentanal oxime
• 英文别名: 5-{[(1,1-dimethylethyl)dimethylsilyl]oxy}pentanal oxime；(NE)-N-[5-[tert-butyl(dimethyl)silyl]oxypentylidene]hydroxylamine
• CAS: 135147-30-7
• 化学式: C₁₁H₂₅NO₂Si
• 分子量: 231.41
• InChiKey: YZOUQGJIVUMFAD-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.64
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>pentanal oxime 、 N-氯代丁二酰亚胺 生成 (1Z)-5-[tert-butyl(dimethyl)silyl]oxy-N-hydroxypentanimidoyl chloride
  参考文献：
  名称：

  KOZIKOWSKI, ALAN P.;SHUM, PATRICK W.;BASU, ALAKANANDA;LAZO, JOHN S., J. MED. CHEM., 34,(1991) N, C. 2420-2430

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(叔丁基二甲基硅杂氧基)-1-戊醇 在 草酰氯 、 盐酸羟胺 、 sodium carbonate 、 二甲基亚砜 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.25h， 生成 5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>pentanal oxime
  参考文献：
  名称：

  Synthesis of structural analogs of lyngbyatoxin A and their evaluation as activators of protein kinase C

  摘要：

  Syntheses of several new analogues of lyngbyatoxin A from a single common intermediate are described. These compounds bear a carbon chain at the 7-position of the indolactam V (ILV) nucleus which contains either a hydrophilic or a lipophilic group. The effect of these minor structural alterations on the ability of the ILV analogues to activate the enzyme protein kinase C (PKC) was determined by measuring the extent of phosphorylation of calf thymus histone (III-S). Introduction of a hydroxyl group on the C-7 appendage was found to dramatically decrease compound 3's ability to activate PKC. This result is interpreted in terms of the decreased ability of 3 to associate with the membrane bilayer.

  DOI：

  10.1021/jm00112a017

文献信息

• KOZIKOWSKI, ALAN P.;SHUM, PATRICK W.;BASU, ALAKANANDA;LAZO, JOHN S., J. MED. CHEM., 34,(1991) N, C. 2420-2430
  作者：KOZIKOWSKI, ALAN P.、SHUM, PATRICK W.、BASU, ALAKANANDA、LAZO, JOHN S.

  DOI：——

  日期：——
• Synthesis of structural analogs of lyngbyatoxin A and their evaluation as activators of protein kinase C
  作者：Alan P. Kozikowski、Patrick W. Shum、Alakananda Basu、John S. Lazo

  DOI：10.1021/jm00112a017

  日期：1991.8

  Syntheses of several new analogues of lyngbyatoxin A from a single common intermediate are described. These compounds bear a carbon chain at the 7-position of the indolactam V (ILV) nucleus which contains either a hydrophilic or a lipophilic group. The effect of these minor structural alterations on the ability of the ILV analogues to activate the enzyme protein kinase C (PKC) was determined by measuring the extent of phosphorylation of calf thymus histone (III-S). Introduction of a hydroxyl group on the C-7 appendage was found to dramatically decrease compound 3's ability to activate PKC. This result is interpreted in terms of the decreased ability of 3 to associate with the membrane bilayer.