(2R)-1-(furan-2-yl)-N-[(1S)-1-phenylethyl]propan-2-amine | 477788-38-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2R)-1-(furan-2-yl)-N-[(1S)-1-phenylethyl]propan-2-amine
• CAS: 477788-38-8
• 化学式: C₁₅H₁₉NO
• 分子量: 229.322
• InChiKey: GLQMDUOUVQLTCK-OLZOCXBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R)-1-(furan-2-yl)-N-[(1S)-1-phenylethyl]propan-2-amine 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 20.0 ℃ 、1300.0 MPa 条件下， 反应 17.0h， 生成 (1R,3R,6S,8R)-3-methyl-4-[(1S)-1-phenylethyl]-11-oxa-5lambda6-thia-4-azatricyclo[6.2.1.01,6]undec-9-ene 5,5-dioxide
  参考文献：
  名称：

  Preparation of enantiopure sultams by intramolecular Diels–Alder reaction of furan-containing vinylsulfonamides

  摘要：

  Enantiomerically pure delta- and gamma-sultams have been prepared by intramolecular [4+2] cycloaddition of N-1-phenylethyl substituted vinylsulforiamides with purely thermal activation and under high pressure, An optimized procedure for reductive debenzylation of the resultant delta-sultams is also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00912-7
• 作为产物：
  描述：

  1-(呋喃-2-基)-2-丙醇 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.75h， 生成 (2R)-1-(furan-2-yl)-N-[(1S)-1-phenylethyl]propan-2-amine
  参考文献：
  名称：

  Preparation of enantiopure sultams by intramolecular Diels–Alder reaction of furan-containing vinylsulfonamides

  摘要：

  Enantiomerically pure delta- and gamma-sultams have been prepared by intramolecular [4+2] cycloaddition of N-1-phenylethyl substituted vinylsulforiamides with purely thermal activation and under high pressure, An optimized procedure for reductive debenzylation of the resultant delta-sultams is also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00912-7

文献信息

• Preparation of enantiopure sultams by intramolecular Diels–Alder reaction of furan-containing vinylsulfonamides
  作者：Viktor O. Rogatchov、Heiko Bernsmann、Pia Schwab、Roland Fröhlich、Birgit Wibbeling、Peter Metz

  DOI：10.1016/s0040-4039(02)00912-7

  日期：2002.7

  Enantiomerically pure delta- and gamma-sultams have been prepared by intramolecular [4+2] cycloaddition of N-1-phenylethyl substituted vinylsulforiamides with purely thermal activation and under high pressure, An optimized procedure for reductive debenzylation of the resultant delta-sultams is also reported. (C) 2002 Elsevier Science Ltd. All rights reserved.