3,4-二羟基呋喃-2,5-二甲酸二乙酯 | 6270-57-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 中文名称: 3,4-二羟基呋喃-2,5-二甲酸二乙酯
• 英文名称: 3,4-dihydroxy-furan-2,5-dicarboxylic acid diethyl ester
• 英文别名: 3,4-Dihydroxy-furan-2,5-dicarbonsaeure-diaethylester；diethyl 3,4-dihydroxy-2,5-furandicarboxylate；3,4-Dihydroxy-2,5-furandicarbonsaeure-diethylester；2,5-Bisethoxycarbonyl-3,4-dihydroxyfuran；2,5-Dicarbethoxy-3,4-dihydroxy-furan；Diethyl 3,4-dihydroxyfuran-2,5-dicarboxylate
• CAS: 6270-57-1
• 化学式: C₁₀H₁₂O₇
• mdl: MFCD00092386
• 分子量: 244.201
• InChiKey: JGCMPUKYPRCPRE-UHFFFAOYSA-N

物化性质

• 熔点：
  178-180

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  7

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2932190090
• 安全说明：
  S24/25

SDS

Name:	Diethyl 3 4-dihydroxyfuran-2 5-dicarboxylate 97% Material Safety Data Sheet
Synonym:
CAS:	6270-57-1

Section 1 - Chemical Product MSDS Name:Diethyl 3 4-dihydroxyfuran-2 5-dicarboxylate 97% Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
6270-57-1	Diethyl 3,4-dihydroxyfuran-2,5-dicarbo	97%	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
May cause respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 6270-57-1: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: pale yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 178 - 180 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C10H12O7
Molecular Weight: 244

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Oxidizing agents, reducing agents, bases.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 6270-57-1 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Diethyl 3,4-dihydroxyfuran-2,5-dicarboxylate - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 6270-57-1: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 6270-57-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 6270-57-1 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3,4-二羟基呋喃-2,5-二甲酸二乙酯 以79%的产率得到
  参考文献：
  名称：

  DALLACKER F.; MUES V., CHEM. BER. , 1975, 108, NO 2, 569-575

  摘要：

  DOI：
• 作为产物：
  描述：

  二乙基2,2-氧代二醋酸盐 、 草酸二乙酯 在 乙醚 、 sodium ethanolate 作用下， 生成 3,4-二羟基呋喃-2,5-二甲酸二乙酯
  参考文献：
  名称：

  Johnson; Johns, American Chemical Journal, 1906, vol. 36, p. 293

  摘要：

  DOI：

文献信息

• N-1H-tetrazol-5-yl-2-thiophene carboxamides,
  申请人：Warner-Lambert Company

  公开号：US04748183A1

  公开（公告）日：1988-05-31

  The present invention is for compounds having the formula of N-1H-tetrazol-5-yl-2-thiophenecarboxamides, N-1H-tetrazol-5-yl-2-pyrrolecarboxamides, N-1H-tetrazol-5-yl-2-furancarboxamides or analogs of each of the carboxamides. The compounds are useful for the treatment of allergic or inflammatory conditions or diseases. Thus, pharmaceutical compositions and methods of use are also the invention. Processes of preparation for the compounds are also the invention.

  本发明涉及具有N-1H-四唑-5-基-2-噻吩羧酰胺、N-1H-四唑-5-基-2-吡咯羧酰胺、N-1H-四唑-5-基-2-呋喃羧酰胺或每种羧酰胺的类似物的化合物。这些化合物可用于治疗过敏或炎症性疾病。因此，药物组合物和使用方法也属于本发明。制备这些化合物的方法也是本发明的一部分。
• Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides
  申请人：Warner-Lambert Company

  公开号：US04824958A1

  公开（公告）日：1989-04-25

  The present invention is for compounds having the formula of N-1H-tetrazol-5-yl-2-thiophenecarboxamides, N-1H-tetrazol-5-yl-2-pyrrolecarboxamides, N-1H-tetrazol-5-yl-2-furancarboxamides or analogs of each of the carboxamides. The compounds are useful for the treatment of allergic or inflammatory conditions or diseases. Thus, pharmaceutical compositions and methods of use are also the invention. Processes of preparation for the compounds are also the invention.

  本发明涉及具有以下化学式的化合物：N-1H-四唑-5-基-2-噻吩羧酰胺，N-1H-四唑-5-基-2-吡咯羧酰胺，N-1H-四唑-5-基-2-呋喃羧酰胺或上述每种羧酰胺的类似物。这些化合物可用于治疗过敏或炎症性状或疾病。因此，本发明还涉及药物组合物和使用方法。本发明还涉及上述化合物的制备方法。
• N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0249236B1

  公开（公告）日：1991-04-24
• Jain et al., Journal of the Indian Chemical Society, 1947, vol. 24, p. 177,179
  作者：Jain et al.

  DOI：——

  日期：——
• MCDONALD E.; SUKSAMRARN A.; WYLLE R. D., J. CHEM. SOC. PERKIN TRANS., PART 1, 1979, NO 7, 1893-1900
  作者：MCDONALD E.、 SUKSAMRARN A.、 WYLLE R. D.

  DOI：——

  日期：——