2,3-Dimethyl-1,7-naphthyridin | 61523-58-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,3-Dimethyl-1,7-naphthyridin
• 英文别名: 2,3-dimethyl-[1,7]naphthyridine；2,3-Dimethyl-1,7-naphthyridine
• CAS: 61523-58-8
• 化学式: C₁₀H₁₀N₂
• mdl: MFCD18802739
• 分子量: 158.203
• InChiKey: KBQHMKMTEXTGMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氨基吡啶-4-醛 以80%的产率得到
  参考文献：
  名称：

  DECORMEILLE M. A.; GUIGNANT F.; QUEGUINER G.; PASTOUR P., J. HETEROCYCL. CHEM., 1976, 13, NO 2, 387-389

  摘要：

  DOI：

文献信息

• [EN] METHODS AND INTERMEDIATES FOR THE PREPARATION OF MACROLACTAMS<br/>[FR] PROCÉDÉS ET INTERMÉDIAIRES POUR LA PRÉPARATION DE MACROLACTAMES
  申请人：MERCK SHARP & DOHME

  公开号：WO2015095430A1

  公开（公告）日：2015-06-25

  The present invention relates to synthetic processes useful in the preparation of macrolactams that inhibit hepatitis C virus (HCV), specifically macrolactam compounds that inhibit the HCV NS3 protease activity and have application in the treatment of conditions caused by HCV. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

  本发明涉及在制备抑制丙型肝炎病毒（HCV）的大环内酰胺类化合物中有用的合成工艺，特别是抑制HCV NS3蛋白酶活性并可用于治疗由HCV引起的病症的大环内酰胺化合物。本发明还包括在所述合成工艺中有用的中间体及其制备方法。
• Inhibitors of Akt Activity
  申请人：Bilodeau Mark T.

  公开号：US20080280899A1

  公开（公告）日：2008-11-13

  The present invention is directed to compounds which contain substituted napthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

  本发明涉及含有取代萘啶的化合物，其抑制Akt，一种丝氨酸/苏氨酸蛋白激酶的活性。本发明还涉及包含该发明化合物的化疗组合物以及使用该发明化合物治疗癌症的方法。
• Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials
  申请人：Arizona Board of Regents on behalf of Arizona State University

  公开号：US10392387B2

  公开（公告）日：2019-08-27

  Thermally assisted delayed fluorescent materials with triad-type materials for use in full color displays and lighting applications with the following generic structures are provided:

  提供了具有以下通用结构的热辅助延迟荧光材料和三元型材料，可用于全彩显示屏和照明应用：
• Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials
  申请人：Arizona Board of Regents on behalf of Arizona State University

  公开号：US10851106B2

  公开（公告）日：2020-12-01

  Thermally assisted delayed fluorescent materials with triad-type materials for use in full color displays and lighting applications with the following generic structures are provided:

  提供了具有以下通用结构的热辅助延迟荧光材料和三元型材料，可用于全彩显示屏和照明应用：
• THUMMEL R. P.; KOHLI D. K., J. HETEROCYCL. CHEM. <JHTC-AD>, 1977, 14, NO 4, 685-686
  作者：THUMMEL R. P.、 KOHLI D. K.

  DOI：——

  日期：——