N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-3-yl]acetamide | 1372891-68-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-3-yl]acetamide
• CAS: 1372891-68-3
• 化学式: C₁₁H₁₄N₄O₂
• 分子量: 234.258
• InChiKey: ADUHCCCANKRXBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  73
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯甲基-3,5-二甲基异噁唑 、 3-乙酰氨基吡唑 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成 N-[1-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]pyrazol-3-yl]acetamide
  参考文献：
  名称：

  3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS

  摘要：

  公式（I）的化合物或其药用盐：其中：Het是5至10成员的杂环芳香环；X为N且Y为CR5；或X为C且Y为S；Z从N和CH中选择；R1从H和C1-2烷基中选择；R2从H、C1-2烷基、OH、—CH2OH和C1-2烷氧基中选择；每个R3独立选择自OH、C1-3烷基、F、Cl、Br、NH2和C1-3烷氧基；R4从C1-3烷基和卤代C1-3烷基中选择；R5从H、C1-3烷基和卤代C1-3烷基中选择；R6和R7要么i）各自独立选择自H、C1-3烷基和C1-3烷氧基；要么ii）R6和R7与它们附着的环一起形成9成员双环环；p为0-3；RA从H和C1-3烷基中选择，提供了含有它们的组合物，它们在治疗中的使用，例如在结核病的治疗中，并提供了这类化合物的制备方法。

  公开号：

  US20130203802A1

文献信息

• Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in composition and use thereof
  申请人：Li Xiaodong

  公开号：US20090274632A1

  公开（公告）日：2009-11-05

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及发现T2R味觉受体家族中特定人类味觉受体对咖啡等中特定苦味化合物的反应。此外，本发明涉及发现特定化合物和含有该化合物的组合物作为苦味阻断剂的功能，以及将其用作苦味阻断剂或调味剂，例如在咖啡和咖啡味食品、饮料和药品中。此外，本发明涉及发现一种对抗多种不同人类T2R的化合物，并将其用于检测中以及作为人类和动物摄入的组合物中的苦味阻断剂。
• Compounds that inhibit (block) bitter taste in composition and methods of making same
  申请人：LI Xiaodong

  公开号：US20110207937A1

  公开（公告）日：2011-08-25

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及发现T2R味觉受体家族中的特定人类味觉受体对存在于咖啡等物质中的特定苦味化合物做出反应。此外，本发明还涉及发现特定化合物和含有该化合物的组合物，其作为苦味味觉阻滞剂的功能以及在咖啡和咖啡味食品、饮料和药品中作为苦味味觉阻滞剂或风味调节剂的使用。此外，本发明还涉及发现一种拮抗多种不同人类T2R的化合物，以及在人类和动物摄入的组合物中作为苦味味觉阻滞剂的使用和试验。
• COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND USE THEREOF
  申请人：KARANEWSKY Donald S.

  公开号：US20120088796A1

  公开（公告）日：2012-04-12

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及到的发现是特定的人类味觉受体T2R味觉受体家族对于存在于咖啡中的特定苦味化合物做出反应。此外，本发明涉及到的发现是特定的化合物和含有这些化合物的组合物，作为苦味阻滞剂或调味剂在例如咖啡和咖啡味食品、饮料和药品中的使用。此外，本发明涉及到的发现是一种拮抗多种不同人类T2R的化合物，其在人类和动物摄入的组合物中可用作测定和苦味阻滞剂。
• Identification of human T2R receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof
  申请人：Karanewsky Donald S.

  公开号：US20100254916A1

  公开（公告）日：2010-10-07

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及发现人类T2R味觉受体家族中特定的味觉受体对咖啡等中的特定苦味化合物产生反应。此外，本发明还涉及特定化合物和含有该化合物的组合物的发现，其作为苦味阻断剂的功能，并且可以在咖啡和咖啡风味食品、饮料和药物中用作苦味阻断剂或风味调节剂。此外，本发明还涉及发现一种对多种不同的人类T2R产生拮抗作用的化合物，并且可以在人类和动物摄入的组合物中用作苦味阻断剂以及用于检测的用途。
• COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND METHODS OF MAKING SAME
  申请人：LI Xiaodong

  公开号：US20130183252A1

  公开（公告）日：2013-07-18

  The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.

  本发明涉及发现人类T2R味觉受体家族中的特定味觉受体对存在于咖啡中的特定苦味化合物做出反应。此外，本发明涉及发现特定化合物和含有该化合物的组合物作为苦味阻滞剂的功能，以及在咖啡和咖啡味食品、饮料和药品中作为苦味阻滞剂或调味剂的使用。此外，本发明涉及发现一种拮抗多种不同人类T2R的化合物，并将其用于测定和作为人类和动物摄入组合物中苦味阻滞剂。