2-methyl-3-(2-methylphenyl)-7-(furan-2-ylmethyleneamino)-4(3H)-quinazolinone | 1364664-37-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-methyl-3-(2-methylphenyl)-7-(furan-2-ylmethyleneamino)-4(3H)-quinazolinone
• 英文别名: 7-(Furan-2-ylmethylideneamino)-2-methyl-3-(2-methylphenyl)quinazolin-4-one
• CAS: 1364664-37-8
• 化学式: C₂₁H₁₇N₃O₂
• 分子量: 343.385
• InChiKey: GZSJVMGERFPVBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-4-硝基苯甲酸 在 盐酸 、 铁粉 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 生成 2-methyl-3-(2-methylphenyl)-7-(furan-2-ylmethyleneamino)-4(3H)-quinazolinone
  参考文献：
  名称：

  Design and synthesis of novel 7-aminoquinazoline derivatives: Antitumor and anticonvulsant activities

  摘要：

  A novel series of 7-substituted-4(3H)-quinazolinone were designed, synthesized and evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad-spectrum antitumor effectiveness toward numerous cell lines that belong to different tumor subpanels, whereas compounds 9 and 18 possess selective activity toward leukemia cell lines. Additionally, compounds 3, 15, 16, 18, 19 and 20 showed advanced anticonvulsant activity as well as lower neurotoxicity than reference drugs. The achieved results proved that the distinctive compounds could be valuable as a model for future devise, acclimatization and investigation to construct more active analogues. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.01.071

文献信息

• Design and synthesis of novel 7-aminoquinazoline derivatives: Antitumor and anticonvulsant activities
  作者：Adel S. El-Azab、Kamal E.H. ElTahir

  DOI：10.1016/j.bmcl.2012.01.071

  日期：2012.3

  A novel series of 7-substituted-4(3H)-quinazolinone were designed, synthesized and evaluated for their antitumor and anticonvulsant activity. Compound 7 revealed broad-spectrum antitumor effectiveness toward numerous cell lines that belong to different tumor subpanels, whereas compounds 9 and 18 possess selective activity toward leukemia cell lines. Additionally, compounds 3, 15, 16, 18, 19 and 20 showed advanced anticonvulsant activity as well as lower neurotoxicity than reference drugs. The achieved results proved that the distinctive compounds could be valuable as a model for future devise, acclimatization and investigation to construct more active analogues. (c) 2012 Elsevier Ltd. All rights reserved.