5-(6-methoxypyridin-3-yl)-2-methylbenzo[d]thiazole | 1186126-55-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 5-(6-methoxypyridin-3-yl)-2-methylbenzo[d]thiazole
• 英文别名: 5-(6-Methoxypyridin-3-YL)-2-methyl-1,3-benzothiazole；5-(6-methoxypyridin-3-yl)-2-methyl-1,3-benzothiazole
• CAS: 1186126-55-5
• 化学式: C₁₄H₁₂N₂OS
• 分子量: 256.328
• InChiKey: JKVRGLABZHVAKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-methylbenzo[d]thiazol-5-yl methanesulfonate 、 2-甲氧基-5-吡啶硼酸 在 potassium phosphate 、 2-(二环己基膦)3,6-二甲氧基-2′,4′,6′-三异丙基-1,1′-联苯 、 palladium diacetate 作用下， 以 2-甲基-2-丁醇 为溶剂， 以85%的产率得到5-(6-methoxypyridin-3-yl)-2-methylbenzo[d]thiazole
  参考文献：
  名称：

  A Versatile Catalyst System for Suzuki−Miyaura Cross-Coupling Reactions of C(sp²)-Tosylates and Mesylates

  摘要：

  A catalyst system for the Suzuki-Miyaura cross-coupling reactions of aryl and vinyl tosylates and mesylates has been developed. This catalyst displays excellent functional group tolerance and allows the coupling of heteroarylboronic acids with aryl tosylates and mesylates to be performed in high yields. Moreover, reactions employing alkylboronic acids, as well as heteroaryl, vinyl, and allylic pinacol boronate esters, were conducted with high efficiencies.

  DOI：

  10.1021/ol9015892

文献信息

• A Versatile Catalyst System for Suzuki−Miyaura Cross-Coupling Reactions of C(sp²)-Tosylates and Mesylates
  作者：Brijesh Bhayana、Brett P. Fors、Stephen L. Buchwald

  DOI：10.1021/ol9015892

  日期：2009.9.3

  A catalyst system for the Suzuki-Miyaura cross-coupling reactions of aryl and vinyl tosylates and mesylates has been developed. This catalyst displays excellent functional group tolerance and allows the coupling of heteroarylboronic acids with aryl tosylates and mesylates to be performed in high yields. Moreover, reactions employing alkylboronic acids, as well as heteroaryl, vinyl, and allylic pinacol boronate esters, were conducted with high efficiencies.