(4-Methyl-3H-inden-1-yl)-acetic acid ethyl ester | 62677-68-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: (4-Methyl-3H-inden-1-yl)-acetic acid ethyl ester
• 英文别名: Ethyl (7-methyl-1H-inden-3-yl)acetate；ethyl 2-(4-methyl-3H-inden-1-yl)acetate
• CAS: 62677-68-3
• 化学式: C₁₄H₁₆O₂
• 分子量: 216.28
• InChiKey: NUADGZJSNDKPLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Gharat Laxmikant Atmaram

  公开号：US20090306082A1

  公开（公告）日：2009-12-10

  The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, a diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxides, pharmaceutically acceptable solvates thereof and the pharmaceutical compositions containing them which are useful in the treatment of allergic and inflammatory diseases including asthma, chronic bronchitis, atopic dermatitis, urticaria, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, eosinophilic granuloma, psoriasis, rheumatoid arthritis, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and reperfusion injury of the brain, chronic glomerulonephritis, endotoxic shock and adult respiratory distress syndrome.

  本发明涉及新型磷酸二酯酶4型（PDE4）抑制剂的化学式（1）及其类似物、互变异构体、对映异构体、二对映异构体、位置异构体、立体异构体、多晶型、药学上可接受的盐、适当的N-氧化物、药学上可接受的溶剂化合物以及含有它们的制药组合物，这些制剂在治疗过敏性和炎症性疾病方面具有用途，包括哮喘、慢性支气管炎、特应性皮炎、荨麻疹、过敏性鼻炎、过敏性结膜炎、春季结膜炎、嗜酸性肉芽肿、牛皮癣、类风湿性关节炎、脓毒性休克、溃疡性结肠炎、克罗恩病、心肌再灌注损伤和脑再灌注损伤、慢性肾小球肾炎、内毒素休克和成人呼吸窘迫综合症。
• Plant growth regulator compounds
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：US11136292B2

  公开（公告）日：2021-10-05

  The present invention relates to relates to novel strigolactone derivatives of formula (I), to processes for preparing these derivatives including intermediate compounds, to seeds comprising these derivatives, to plant growth regulator or seed germination promoting compositions comprising these derivatives and to methods of using these derivatives in controlling the growth of plants and/or promoting the germination of seeds.

  本发明涉及式（I）的新型绞股蓝内酯衍生物、制备这些衍生物（包括中间体化合物）的工艺、包含这些衍生物的种子、包含这些衍生物的植物生长调节剂或促进种子萌发的组合物，以及使用这些衍生物控制植物生长和/或促进种子萌发的方法。
• PLANT GROWTH REGULATOR COMPOUNDS
  申请人：Syngenta Participations AG

  公开号：EP3512843B1

  公开（公告）日：2021-10-20
• US7943634B2
  申请人：——

  公开号：US7943634B2

  公开（公告）日：2011-05-17