JC010 | 1257404-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: JC010
• 英文别名: 1-[(3,4-Dihydroxyphenyl)methyl]-3-octylurea
• CAS: 1257404-72-0
• 化学式: C₁₆H₂₆N₂O₃
• 分子量: 294.394
• InChiKey: QXQLXFYQTRMFCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  81.6
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  正辛基异氰酸酯 、 3,4-二羟基苄胺·氢溴酸 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 以9.8%的产率得到JC010
  参考文献：
  名称：

  [EN] NOVEL USES
  [FR] NOUVELLES UTILISATIONS

  摘要：

  公开号：

  WO2010144059A3

文献信息

• [EN] NOVEL COMPOUNDS AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSÉS ET LEURS UTILISATIONS
  申请人：NANYANG POLYTECHNIC

  公开号：WO2010144055A1

  公开（公告）日：2010-12-16

  The invention relates to compounds represented by the general formula (I): and pharmaceutically acceptable salts thereof, wherein n is an integer from 1 to 5; p is an integer from 0 to 4; R1 is selected from the group consisting of a hydroxyl group, an alkoxy group, a thiol group, and a thioether group; R2 and R3 are independently a methylene group or a nucleophile, with the proviso that at least one of R2 and R3 is a nucleophile group; Z is an oxygen (O) atom or sulfur (S) atom; T is hydrogen or an optionally substituted aliphatic group; with the proviso that when n = 2, R1 is not -OCH3 on the carbon-3 position of the phenyl group and R1 is not -OH on the carbon-4 position of the phenyl group.

  该发明涉及由通式（I）表示的化合物及其药学上可接受的盐，其中n是1到5的整数；p是0到4的整数；R1从羟基、烷氧基、硫醇基和硫醚基组成的群体中选取；R2和R3独立地是亚甲基基团或亲核试剂，但至少其中之一是亲核试剂基团；Z是氧（O）原子或硫（S）原子；T是氢或可选择取代的脂肪族基团；但当n=2时，R1不是苯基的碳-3位置上的-甲氧基，且R1不是苯基的碳-4位置上的-羟基。
• NOVEL USES
  申请人：Richards Mark

  公开号：US20120083532A1

  公开（公告）日：2012-04-05

  The present invention relates to the use of a compound represented by the general formula (I), and pharmaceutically acceptable salts thereof, wherein: n is an integer from 2 to 5; p is an integer from 0 to 4; R1 is selected from the group consisting of a hydroxyl group, an alkoxy group, a thiol group, a thioether group, and an amino group, wherein at least two of R 1 is a hydroxyl group, a thiol group or an amino group, with the proviso that wherein n is 2, R 1 is not on the carbon-2 position and the carbon-5 position of the phenyl group; R 2 and R 3 are independently a methylene group or a nucleophile, with the proviso that at least one of R 2 and R 3 is a nucleophile group; Z is an oxygen (O) atom or sulfur (S) atom; T is hydrogen or an optionally substituted aliphatic group; in the manufacture of a medicament for treating a patient in need of cell therapy.
• US8703822B2
  申请人：——

  公开号：US8703822B2

  公开（公告）日：2014-04-22
• [EN] NOVEL USES<br/>[FR] NOUVELLES UTILISATIONS
  申请人：NANYANG POLYTECHNIC

  公开号：WO2010144059A3

  公开（公告）日：2011-02-24