3,6-二溴-1,8-萘啶 | 17965-79-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 3,6-二溴-1,8-萘啶
• 英文名称: 3,6-Dibrom-1,8-naphthyridin
• 英文别名: 3,6-Dibromo-1,8-naphthyridine
• CAS: 17965-79-6
• 化学式: C₈H₄Br₂N₂
• 分子量: 287.941
• InChiKey: MSXZKKXCUFRJFQ-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(Solv: ethanol (64-17-5))
• 沸点：
  326.9±37.0 °C(Predicted)
• 密度：
  2.022±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Phenyl-5-methyl-1,2,3-triazol 、 3,6-二溴-1,8-萘啶 在 trans-di-µ-acetatebis[2-(di-o-tolylphosphino)benzyl]dipalladium (II) sodium acetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 23.0h， 生成 (6-bromo-[1,8]naphthyridine-3-yl)-1-phenyl-5-methyl-1H-[1,2,3]triazole
  参考文献：
  名称：

  EP1726585

  摘要：

  公开号：

文献信息

• 1,8-Naphthyridine compound and organic light-emitting device using the same
  申请人：Suzuki Koichi

  公开号：US20060286408A1

  公开（公告）日：2006-12-21

  Provided a novel 1,8-naphthyridine compound represented by the following general formula [I]: wherein R 1 to R 6 each represent one selected from the group consisting of a hydrogen atom; an alkyl group, an aralkyl group, an aryl group, a heterocyclic group, a condensed polycyclic aromatic group, a condensed polycyclic heterocyclic group and an aryloxy group which may be substituted; a substituted amino group; a halogen atom; a trifluromethyl group; and a cyano group, and may be the same as or different from one another, provided that at least two of R 1 to R 6 each represent one selected from the group consisting of an aralkyl group, an aryl group, a heterocyclic group, a condensed polycyclic aromatic group, a condensed polycyclic heterocyclic group and an aryloxy group which may be substituted; and a substituted amino group.

  提供一种由以下通式[I]表示的新型1,8-萘啶化合物：其中R1至R6各自表示选自氢原子;烷基、芳基烷基、芳基、杂环基、紧缩多环芳香基、紧缩多环杂环基和可能被取代的芳氧基; 取代氨基; 卤素原子; 三氟甲基基团; 和氰基的基团，可以相同或不同，但至少有两个R1至R6表示选自芳基烷基、芳基、杂环基、紧缩多环芳香基、紧缩多环杂环基和可能被取代的芳氧基; 和取代氨基的基团。
• Dairyl-substituted five-membered heterocycle derivative
  申请人：Hirata Yukari

  公开号：US20070173507A1

  公开（公告）日：2007-07-26

  The present invention provides the compounds represented by formula (I): (I) or pharmaceutical salts thereof, wherein: X 1 represents oxygen atoms and the like, X 2 represents nitrogen atoms and the like, X 3 represents nitrogen atoms and the like, X 4 represents nitrogen atoms and the like, R 1 represents formula (II-1): wherein X 5 represents sulfur atoms and the like, A 1 represents carbon atoms and the like, A 2 represents nitrogen atoms and the like and A ring represents phenyl group and the like, having mGluR1 inhibiting effect, and being usefull for preventing or treating convulsion, acute pain, inflammatory pain, chronic pain, brain disorder such as cerebral infarction or transient ischemick attack, psychotic disorder such as schizophrenia, anxiety, drug dependence, Parkinson's disease, or gastrointestinal disorder.

  本发明提供了由公式（I）所表示的化合物：（I）或其药物盐，其中：X1代表氧原子等，X2代表氮原子等，X3代表氮原子等，X4代表氮原子等，R1代表公式（II-1）：其中X5代表硫原子等，A1代表碳原子等，A2代表氮原子等，A环代表苯基等，具有mGluR1抑制作用，适用于预防或治疗惊厥、急性疼痛、炎症性疼痛、慢性疼痛、脑部疾病如脑梗死或短暂性脑缺血发作、精神疾病如精神分裂症、焦虑、药物依赖、帕金森病或胃肠道疾病。
• DIARYL-SUBSTITUTED FIVE-MEMBERED HETEROCYCLE DERIVATIVE
  申请人：Hirata Yukari

  公开号：US20110160208A1

  公开（公告）日：2011-06-30

  The present invention provides the compounds represented by formula (I): or pharmaceutical salts thereof, wherein: X 1 represents oxygen atoms and the like, X 2 represents nitrogen atoms and the like, X 3 represents nitrogen atoms and the like, X 4 represents nitrogen atoms and the like, R 1 represents formula (II-1): wherein X 5 represents sulfur atoms and the like, A 1 represents carbon atoms and the like, A 2 represents nitrogen atoms and the like and A ring represents phenyl group and the like, having mGluR1 inhibiting effect, and being useful for preventing or treating convulsion, acute pain, inflammatory pain, chronic pain, brain disorder such as cerebral infarction or transient ischemick attack, psychotic disorder such as schizophrenia, anxiety, drug dependence, Parkinson's disease, or gastrointestinal disorder.

  本发明提供了以下式子(I)所代表的化合物或其药物盐，其中：X1代表氧原子等，X2代表氮原子等，X3代表氮原子等，X4代表氮原子等，R1代表式子(II-1)：其中X5代表硫原子等，A1代表碳原子等，A2代表氮原子等，环A代表苯基等，具有mGluR1抑制作用，并且对于预防或治疗惊厥、急性疼痛、炎症性疼痛、慢性疼痛、脑部疾病如脑梗死或短暂性缺血性发作、精神障碍如精神分裂症、焦虑、药物依赖、帕金森病或胃肠疾病有用。
• US7833634B2
  申请人：——

  公开号：US7833634B2

  公开（公告）日：2010-11-16
• US7902369B2
  申请人：——

  公开号：US7902369B2

  公开（公告）日：2011-03-08