(4-Phenylmethoxynaphthalen-1-yl) acetate | 352200-67-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (4-Phenylmethoxynaphthalen-1-yl) acetate
• 英文别名: (4-phenylmethoxynaphthalen-1-yl) acetate
• CAS: 352200-67-0
• 化学式: C₁₉H₁₆O₃
• 分子量: 292.334
• InChiKey: HWSQVCFFAPYCCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-Phenylmethoxynaphthalen-1-yl) acetate 在 sodium hydroxide 、 水 、 cesium fluoride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.33h， 生成 (+/-)-1-benzyloxy-4-(oxiranylmethoxy)naphthalene
  参考文献：
  名称：

  Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

  摘要：

  Both (R)- and (S)-enantiomes of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%. (C) 2001 Elsevier Science Ltd. All rights, reserved.

  DOI：

  10.1016/s0957-4166(01)00122-7
• 作为产物：
  描述：

  1,4-二羟基萘 在 吡啶 、 sodium tetrahydroborate 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 (4-Phenylmethoxynaphthalen-1-yl) acetate
  参考文献：
  名称：

  Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene

  摘要：

  Both (R)- and (S)-enantiomes of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%. (C) 2001 Elsevier Science Ltd. All rights, reserved.

  DOI：

  10.1016/s0957-4166(01)00122-7

文献信息

• Synthesis of enantiomeric 4-hydroxypropranolols from 1,4-dihydroxynaphthalene
  作者：Takuya Kumamoto、Naho Aoyama、Satoko Nakano、Tsutomu Ishikawa、Shizuo Narimatsu

  DOI：10.1016/s0957-4166(01)00122-7

  日期：2001.4

  Both (R)- and (S)-enantiomes of 4-hydroxypropranolol were effectively prepared from 1,4-dihydroxynaphthalene in eight steps. The overall yields were around 30%. (C) 2001 Elsevier Science Ltd. All rights, reserved.