3,7-二甲基苯并[b]噻吩 | 16587-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 中文名称: 3,7-二甲基苯并[b]噻吩
• 英文名称: 3,7-Dimethylbenzothiophene
• 英文别名: 3,7-dimethyl-benzo[b]thiophene；3,7-Dimethyl-benzo[b]thiophen；3,7-Dimethyl-benzothiophen；Benzo[b]thiophene, 3,7-dimethyl-；3,7-dimethyl-1-benzothiophene
• CAS: 16587-41-0
• 化学式: C₁₀H₁₀S
• 分子量: 162.255
• InChiKey: YFVIULBUVVXJQI-UHFFFAOYSA-N

物化性质

• 熔点：
  30-31 °C
• 沸点：
  122-124 °C(Press: 12 Torr)
• 密度：
  1.114±0.06 g/cm3(Predicted)
• 保留指数：
  1414.5

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,7-二甲基苯并[b]噻吩 生成 2-Bromo-3,7-dimethyl-1-benzothiophene
  参考文献：
  名称：

  CROSS, P. E.;DICKINSON, R. P.;THOMAS, G. N.

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(o-tolylthio)propan-2-one 在 phosphorus pentoxide 作用下， 生成 3,7-二甲基苯并[b]噻吩
  参考文献：
  名称：

  Banfield et al., Journal of the Chemical Society, 1956, p. 4791,4798

  摘要：

  DOI：

文献信息

• SULTAM DERIVATIVES
  申请人：MAEKAWARA Naomi

  公开号：US20090192154A1

  公开（公告）日：2009-07-30

  A sultam derivative of Formula (1) described below having inhibitory action for aggrecanase activity is provided. The sultam derivative of Formula (1) and a salt thereof exhibit strong inhibitory action for aggrecanase activity in a living body of a mammalian animal including human, and is useful, for example, as an active ingredient of a pharmaceutical agent for preventing and/or treating various diseases caused by degradation of aggrecan.

  提供一种以下式（1）描述的磺酰胺衍生物，具有对聚集素酶活性的抑制作用。该式（1）的磺酰胺衍生物及其盐在哺乳动物包括人类的活体内表现出对聚集素酶活性的强抑制作用，并且可用作制药剂的活性成分，用于预防和/或治疗由聚集素降解引起的各种疾病。
• BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：Bloxham Jason

  公开号：US20100173886A1

  公开（公告）日：2010-07-08

  Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.

  化合物式(I)或其药学上可接受的盐，是阿片受体调节剂，例如μ-阿片受体拮抗剂，中性拮抗剂或倒向激动剂，并且可用于治疗代谢性疾病，包括肥胖症。
• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• GAMMA SECRETASE MODULATORS
  申请人：Huang Xianhai

  公开号：US20110015190A1

  公开（公告）日：2011-01-20

  This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R 2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

  本发明提供了一种新型化合物，其为γ-分泌酶的调节剂。该化合物的化学式为(I)，其中R2是化学式(II)的融合双环。此外，还揭示了利用化合物(I)调节γ-分泌酶活性和治疗阿尔茨海默病的方法。
• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2765187A1

  公开（公告）日：2014-08-13

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, comprising separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein R1 to R7, W, X, Y, Z, Ar1 and n are as defined in the description) to differentiate them into megakaryocytes and/or platelets.

  提供了一种诱导多能干细胞产生巨核细胞和/或血小板的制剂，该制剂可用于治疗伴随血小板减少的疾病。 一种生产巨核细胞和/或血小板的方法，包括在多能干细胞产生的囊状结构中将造血祖细胞从隔细胞中分离出来，并在由式（I）代表的化合物（其中R1至R7、W、X、Y、Z、Ar1和n如描述中所定义）存在下体内外培养造血祖细胞，使其分化成巨核细胞和/或血小板。