3,7-二甲基苯并呋喃 | 71507-42-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 3,7-二甲基苯并呋喃
• 英文名称: 3,7-dimethylbenzofuran
• 英文别名: 3,7-Dimethyl-cumaron；3,7-dimethyl-1-benzofuran
• CAS: 71507-42-1
• 化学式: C₁₀H₁₀O
• 分子量: 146.189
• InChiKey: NIYDFNQGKTVQRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,7-二甲基苯并呋喃 在 三氯化铝 、 (-)-diisopinocamphenylborane chloride 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 18.0h， 生成 (R)-(-)-2-chloro-1-(3,7-dimethylbenzofuran-2-yl)ethanol
  参考文献：
  名称：

  Enantioselective reduction of benzofuryl halomethyl ketones: asymmetric synthesis of (R)-bufuralol

  摘要：

  Enantioselective reduction of representative 2-(bromoacetyl)- and 2-(chloroacetyl)benzofurans with (-)-B-chloro-diisopinocampheylborane and by transfer hydrogenation with formic acid/triethylamine in the presence of RhCl[R,R-TsD-PEN](C5Me5) is described. Transfer hydrogenation of the chloro ketones produced the corresponding chlorohydrins of >= 95% ee. (R)-Bufuralol of 96% ce was prepared from the corresponding chloro ketone by transfer hydrogenation-substitution. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.08.012
• 作为产物：
  描述：

  o-Tolyloxy-aceton 在 硫酸 作用下， 生成 3,7-二甲基苯并呋喃
  参考文献：
  名称：

  Stoermer, Justus Liebigs Annalen der Chemie, 1900, vol. 312, p. 289

  摘要：

  DOI：

文献信息

• [EN] PYRROLOPYRROLE DERIVATIVES, THEIR MANUFACTURE AND USE AS SEMICONDUCTORS<br/>[FR] DÉRIVÉS DE PYRROLOPYRROLE, PROCÉDÉ DE FABRICATION DE CEUX-CI ET LEUR UTILISATION COMME SEMI-CONDUCTEURS
  申请人：BASF SE

  公开号：WO2010115767A1

  公开（公告）日：2010-10-14

  The present invention relates to compounds of the formula (I) wherein the substituents are as defined in claim 1, and their use as organic semiconductor in organic devices, like diodes, organic field effect transistors and/or solar cells. The compounds of the formula I have excellent solubility in organic solvents. High efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when said compounds are used in semiconductor devices or organic photovoltaic (PV) devices (solar cells).

  本发明涉及式（I）的化合物，其中取代基如权利要求1所定义，并且它们在有机器件中的用途，例如二极管、有机场效应晶体管和/或太阳能电池中的用途作为有机半导体。式I的化合物在有机溶剂中具有优异的溶解性。当这些化合物用于半导体器件或有机光伏（PV）器件（太阳能电池）时，可以观察到高能量转换效率、优异的场效应迁移率、良好的开关电流比和/或优异的稳定性。
• SULTAM DERIVATIVES
  申请人：MAEKAWARA Naomi

  公开号：US20090192154A1

  公开（公告）日：2009-07-30

  A sultam derivative of Formula (1) described below having inhibitory action for aggrecanase activity is provided. The sultam derivative of Formula (1) and a salt thereof exhibit strong inhibitory action for aggrecanase activity in a living body of a mammalian animal including human, and is useful, for example, as an active ingredient of a pharmaceutical agent for preventing and/or treating various diseases caused by degradation of aggrecan.

  提供一种以下式（1）描述的磺酰胺衍生物，具有对聚集素酶活性的抑制作用。该式（1）的磺酰胺衍生物及其盐在哺乳动物包括人类的活体内表现出对聚集素酶活性的强抑制作用，并且可用作制药剂的活性成分，用于预防和/或治疗由聚集素降解引起的各种疾病。
• Retinoid x receptor modulators
  申请人：Gardinier M. Kevin

  公开号：US20080090860A1

  公开（公告）日：2008-04-17

  The present invention is directed to compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof: The invention is also directed to pharmaceutical compositions, methods of use and methods of making compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof.

  本发明涉及由结构式I表示的化合物及其药学上可接受的盐、溶剂合物和水合物。本发明还涉及制备由结构式I表示的化合物及其药学上可接受的盐、溶剂合物和水合物的医药组合物、使用方法和制备方法。
• PYRROLOPYRROLE DERIVATIVES, THEIR MANUFACTURE AND USE AS SEMICONDUCTORS
  申请人：Hayoz Pascal

  公开号：US20120095236A1

  公开（公告）日：2012-04-19

  The present invention relates to compounds of the formula (I) wherein the substituents are as defined in claim 1 , and their use as organic semiconductor in organic devices, like diodes, organic field effect transistors and/or solar cells. The compounds of the formula I have excellent solubility in organic solvents. High efficiency of energy conversion, excellent field-effect mobility, good on/off current ratios and/or excellent stability can be observed, when said compounds are used in semiconductor devices or organic photovoltaic (PV) devices (solar cells).

  本发明涉及式(I)中所述取代基的化合物，其中所述取代基如权利要求1所定义，并且它们作为有机半导体在有机器件中的使用，例如二极管、有机场效应晶体管和/或太阳能电池。式I的化合物具有优异的有机溶剂溶解性。当所述化合物用于半导体器件或有机光伏（PV）器件（太阳能电池）时，可以观察到高效能转换率、优异的场效应迁移率、良好的开关电流比和/或优异的稳定性。
• BICYCLIC ARYL AND HETEROARYL COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：Bloxham Jason

  公开号：US20100173886A1

  公开（公告）日：2010-07-08

  Compounds of formula (I): or pharmaceutically acceptable salts thereof, are opioid receptor modulators, e.g. mu-opioid receptor antagonists, neutral antagonists or inverse agonists, and are useful for the treatment of metabolic disorders including obesity.

  化合物式(I)或其药学上可接受的盐，是阿片受体调节剂，例如μ-阿片受体拮抗剂，中性拮抗剂或倒向激动剂，并且可用于治疗代谢性疾病，包括肥胖症。