1-Amino-3-inden-3-ylpropane | 15940-43-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 1-Amino-3-inden-3-ylpropane
• 英文别名: 3-<3-Amino-propyl>-inden；3-(3H-inden-1-yl)propan-1-amine
• CAS: 15940-43-9
• 化学式: C₁₂H₁₅N
• 分子量: 173.258
• InChiKey: VSEHDBAKCTZDBN-UHFFFAOYSA-N

物化性质

• 沸点：
  295.3±19.0 °C(Predicted)
• 密度：
  1.033±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Amino-3-inden-3-ylpropane 在 sodium tetrahydroborate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 50.0h， 生成 N-Benzyl-2,3-dihydrospiro<1H-indene-1,2'-pyrrolidine>
  参考文献：
  名称：

  Intramolecular photoaddition of secondary .alpha.-(aminoalkyl)styrenes

  摘要：

  The photophysical and photochemical behavior of a aeries of alpha-[(N-methylamino)alkyl]styrenes with two to four methylenes separating the styryl and amino groups and an (aminoalkyl)indene have been investigated and the results compared to those for the intermolecular reaction of alpha-methylstyrene with diethylamine. Both inter- and intramolecular quenching of styrene fluorescence by the amine is observed, indicative of electron-transfer quenching as the initial step in these reactions. The resulting exciplex undergoes regioselective N-H proton transfer to styrene C-beta yielding a biradical, in the case of the intramolecular reaction, and a radical pair, in the case of the intermolecular reaction. Biradical or radical pair combination yields styrene-amine addition products. The conformation of the intermediate exciplex is proposed to control the regioselectivity of the intramolecular N-H proton transfer process.

  DOI：

  10.1021/jo00075a037
• 作为产物：
  描述：

  2-茚酮 在 sodium tetrahydroborate 、 lithium aluminium tetrahydride 、 sodium 、 对甲苯磺酸 作用下， 以 甲醇 、 乙醚 、 乙醇 、 苯 为溶剂， 反应 35.25h， 生成 1-Amino-3-inden-3-ylpropane
  参考文献：
  名称：

  Intramolecular photoaddition of secondary .alpha.-(aminoalkyl)styrenes

  摘要：

  The photophysical and photochemical behavior of a aeries of alpha-[(N-methylamino)alkyl]styrenes with two to four methylenes separating the styryl and amino groups and an (aminoalkyl)indene have been investigated and the results compared to those for the intermolecular reaction of alpha-methylstyrene with diethylamine. Both inter- and intramolecular quenching of styrene fluorescence by the amine is observed, indicative of electron-transfer quenching as the initial step in these reactions. The resulting exciplex undergoes regioselective N-H proton transfer to styrene C-beta yielding a biradical, in the case of the intramolecular reaction, and a radical pair, in the case of the intermolecular reaction. Biradical or radical pair combination yields styrene-amine addition products. The conformation of the intermediate exciplex is proposed to control the regioselectivity of the intramolecular N-H proton transfer process.

  DOI：

  10.1021/jo00075a037

文献信息

• [EN] IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS<br/>[FR] DERIVES IMIDAZOLYLES COMME INHIBITEURS DU FACTEUR DE LIBERATION DE LA CORTICOTROPINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002058704A1

  公开（公告）日：2002-08-01

  The present invention relates to novel heterocyclic antagonists of Formula I and pharmaceutical compositions comprising said antagonists of the coticotropin releasing factor receptor ('CRF receptor') (formula), useful for the treatment of depression, anxiety, affective disorders, feeding disorders, post-traumatic stress disorder, headache, drug addiction, inflammatory disorders, drug or alcohol withdrawal symptoms and other conditions the treatment of which can be effected by the antagonism of the CRF-1 receptor.

  本发明涉及公式I的新型杂环拮抗剂和包含所述拮抗剂的药物组合物，该药物组合物对促肾上腺皮质激素释放因子受体（'CRF受体'）具有拮抗作用，用于治疗抑郁症、焦虑症、情感障碍、饮食障碍、创伤后应激障碍、头痛、药物成瘾、炎症性疾病、药物或酒精戒断症状和其他可以通过CRF-1受体的拮抗作用治疗的疾病。
• Crown ether-substituted indene and 3,4-dimethylcyclopentadiene
  作者：Herbert Plenio、Ralph Diodone

  DOI：10.1021/jo00076a025

  日期：1993.11

  Several indene and cyclopentadiene derivatives have been synthesized, which are substituted with crown ethers, thereby creating ligands whose heterotopic faces have the ability to function as ligands in both organometallic and coordination chemistry. The syntheses of mono- and bis-N-3-indenylpropyl-substituted aza-12-crown-4 4, aza-15-crown-5 5, and diaza-18-crown-6 6 ether compounds are described. However it was not possible to isolate stable eta5-bound metal complexes with 4, 5, or 6. In an alternative approach 1-(2-aminoethyl)-3,4-dimethyl-cyclopenta-1,3-diene (9) has been prepared from 3,4-dimethylcyclopent-2-enone (7) via Knoevenagel condensation, followed by reduction of the alpha,beta,gamma,delta-unsaturated nitrile 8 with LiAlH4/AlCl3. CYClization of 9 produced the first example of crown ether-substituted cyclopentadienes, N-[2-(3,4-dimethylcyclopenta-1,3-dienyl)ethyl]aza-12-C-4 (10) (12-C-4-HCp''), and as the result of a 2 + 2 addition, N,N'-bis[2-(3,4-dimethylcyclopenta-1,3-dienyl)ethyl]1,13-diaza-24-crown-8 (11) (24-C-8-HCp''2). Reaction of 10 with NaH, (CO)3W(CH3CN)3, and CH3I affords the eta5-bound complex (12-C-4-Cp'')W(CO)3CH3 (12), which in turn can complex Na+ to give 13 (=(12)2.Na+BPh4-).
• IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1359916A1

  公开（公告）日：2003-11-12
• EP1359916A4
  申请人：——

  公开号：EP1359916A4

  公开（公告）日：2004-04-07
• US4044040A
  申请人：——

  公开号：US4044040A

  公开（公告）日：1977-08-23