4-(4-Chlorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)-1,4,5,6-tetrahydrobenzo[h]quinazoline | 1187456-06-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-Chlorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)-1,4,5,6-tetrahydrobenzo[h]quinazoline
• CAS: 1187456-06-9
• 化学式: C₂₇H₂₆ClN₅
• 分子量: 455.99
• InChiKey: MSNNRYGNMIHBPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-Pyridin-2-ylpiperazine-1-carboximidamide sulfate 、 2-(4-chlorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one 在 potassium tert-butylate 作用下， 以 甲醇 为溶剂， 生成 4-(4-chloro-phenyl)-2-(4-pyridin-2-yl-piperazin-1-yl)-5,6-dihydro-benzo[h]quinazoline 、 4-(4-Chlorophenyl)-2-(4-pyridin-2-ylpiperazin-1-yl)-1,4,5,6-tetrahydrobenzo[h]quinazoline
  参考文献：
  名称：

  Design and synthesis of novel substituted quinazoline derivatives as antileishmanial agents

  摘要：

  4-(Substituted-benzylidine)-2-substituted-5,6-dihydrobenzo[h]quinazoline (5a-p) and 4-(substituted-benzylidine)-2-substituted-3, 4, 5, 6-tetrahydrobenzo[h]quinazoline (6a-p) have been synthesized from 2-(substituted-benzylidine)tetralone-1(3a-d) and several substituted guanidine sulfates(4a-d). These compounds were tested for their in vitro antileishmanial activity. The compounds 6i, 6f, 6g show promising antileishmanial activity against Leishmania donovani. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.081