2,2,2-trichloro-1-p-toluidino-ethanol | 448248-25-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2,2-trichloro-1-p-toluidino-ethanol
• 英文别名: (β.β.β-Trichlor-α-oxy-aethyl)-p-toluidin；2,2,2-Trichlor-1-p-toluidino-aethanol；Chloral-p-toluidin；2,2,2-Trichloro-1-(4-methylanilino)ethanol
• CAS: 448248-25-7
• 化学式: C₉H₁₀Cl₃NO
• 分子量: 254.543
• InChiKey: DHVTWXLFCXBKSK-UHFFFAOYSA-N

物化性质

• 沸点：
  363.6±42.0 °C(Predicted)
• 密度：
  1.464±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,2-trichloro-1-p-toluidino-ethanol 以 苯 为溶剂， 生成 N-(2,2,2-trichloroethylidene)-p-toluidine
  参考文献：
  名称：

  有机金属反应。第十九部分。醛与氨基锡化合物的一些反应

  摘要：

  N-苯基六丁基二萘烷与乙醛反应，生成氧化双三丁醚和亚乙基苯胺。在氯醛和N-乙基二烷间烷之间发生类似的反应，得到2,2,2-三氯亚乙基乙胺和相应的二锡烷。然而，使用N-芳基六丁基二锡烷时，氯醛的反应更为复杂。最初形成2：1的氯醛-二烷氮烷加合物，现在的分解产物包括三丁基三氯甲基锡和N-三丁基锡烷基甲酰胺基。

  DOI：

  10.1039/j39710000068
• 作为产物：
  描述：

  乙烷,三氯氟- 、 三氯乙醛 生成 2,2,2-trichloro-1-p-toluidino-ethanol
  参考文献：
  名称：

  Eibner, Justus Liebigs Annalen der Chemie, 1898, vol. 302, p. 349

  摘要：

  DOI：

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Sn: Org.Comp.12, 1.4.1.1.1.5.2.1.7, page 69 - 97
  作者：

  DOI：——

  日期：——
• Wallach, Justus Liebigs Annalen der Chemie, 1874, vol. 173, p. 289
  作者：Wallach

  DOI：——

  日期：——
• Synthesis, characterization, antitumor, and cytotoxic activity of mononuclear Ru(II) complexes
  作者：Sreekanth Thota、Subhas Somalingappa Karki、K.N. Jayaveera、Jan Balzarini、Erik De Clercq

  DOI：10.1080/00958972.2010.534140

  日期：2010.12.20

  In the search for antitumor active metal complexes several ruthenium complexes have been reported to be promising. A series of mononuclear Ru(II) complexes, [Ru(T)2(S)]2+, where T = 2,2'-bipyridine/1,10-phenanthroline and S = CH3-bitsz, Cl-bitsz, Br-bitsz, tmtsz, dmtsz, have been prepared and characterized by UV-Vis, IR, 1H-NMR, FAB-mass spectroscopy, and elemental analysis. The complexes were subjected to invivo anticancer activity against a transplantable murine tumor cell line Ehrlich's ascitic carcinoma (EAC) and invitro cytotoxic activity against human cancer cell line Molt 4/C8, CEM, and murine tumor cell line L1210. Ruthenium complexes showed promising biological activity especially in decreasing tumor volume and viable ascitic cell counts. Treatment with these complexes prolonged the life span of EAC-tumor-bearing mice by 10-48%. Invitro evaluation of these ruthenium complexes revealed cytotoxic activity from 0.21 to 24 mu mol L-1 against Molt 4/C8, 0.16-19 mu mol L-1 against CEM, and 0.75-32 mu mol L-1 against L1210 cell proliferation, depending on the nature of the compound.
• Synthesis and Characterization of O,O-Dimethyl-N-(2,2,2-trichloro-1-arylaminoethyl) Phosphoramidothioates
  作者：Baolei Wang、Xinghai Liu、Zhengming Li

  DOI：10.1080/10426500802453807

  日期：2009.9.18

  Several novel trichloromethyl-containing O,O-dimethyl phosphoramidothioate derivatives have been synthesized by the reaction of O, O-dimethyl phosphoramidothioate with chloral imines. The latter were prepared in good yields by refluxing the dichloroethane solution of chloral and substituted anilines using 3 angstrom molecular sieves as dehydrating agent. Structures of title compounds were confirmed by IR, H-1 NMR, P-31 NMR, and FT-MS studies.
• Eibner, Justus Liebigs Annalen der Chemie, 1898, vol. 302, p. 349
  作者：Eibner

  DOI：——

  日期：——