9-Methyl-thioxanthen | 16860-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 英文名称: 9-Methyl-thioxanthen
• 英文别名: 9-methyl-9H-thioxanthene
• CAS: 16860-11-0
• 化学式: C₁₄H₁₂S
• 分子量: 212.315
• InChiKey: APSZBCZZVNSQOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-Methyl-thioxanthen 以37%的产率得到
  参考文献：
  名称：

  TAMURA Y.; NISHIKAWA Y.; MUKAI C.; SUMOTO K.; IKEDA M.; KISE M., J. ORG. CHEM., 1979, 44, NO 10, 1684-1690

  摘要：

  DOI：
• 作为产物：
  描述：

  10-Methylthioxanthenium tetrafluoroborate 以 氘代乙腈 为溶剂， 反应 1.0h， 生成 9-Methyl-thioxanthen
  参考文献：
  名称：

  Excited state carbon acids: irreversible photodeprotonation of the benzylic protons of 10-methyl- and 10-phenyl-thioxanthenium salts

  摘要：

  首次报道了通过光解硫杂蒽盐，C-H键不可逆光解质子化生成碳正离子，并生成相应的硫鎓（硫蒽）和酸（HBF4或HClO4）。

  DOI：

  10.1039/a608434f

文献信息

• MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
  申请人：Weinstein David S.

  公开号：US20090075995A1

  公开（公告）日：2009-03-19

  Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B is a cycloalkyl, cycloalkenyl, aryl, heterocyclo, or heteroaryl ring, wherein each ring is fused to the A ring on adjacent atoms and optionally substituted by one to four groups which are the same or different and are independently selected from R 5 , R 6 , R 7 , and R 8 ; J 1 , J 2 , and J 3 are at each occurrence the same or different and are independently -A 1 QA 2 -; Q is a bond, O, S, S(O), or S(O) 2 ; A 1 and A 2 are the same or different and are at each occurrence independently selected from a bond, C 1-3 alkylene, substituted C 1-3 alkylene, C 2-4 alkenylene, and substituted C 2-4 alkenylene, provided that A 1 and A 2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R 1 to R 11 are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.

  提供了一系列新颖的非甾体化合物，这些化合物在治疗与糖皮质激素受体、AP-1和/或NF-κB活性调节相关的疾病中很有用，包括炎性和免疫疾病，具有以下结构式（I）： 其对应的光学异构体、对映异构体或互变异构体，或其前药酯，或其药用可接受盐，其中： Z是杂环或杂芳基； A是一个5至8成员的碳环或一个5至8成员的杂环； B是一个环烷基、环烯基、芳基、杂环或杂芳基环，其中每个环都与A环上的相邻原子融合，并且可以选择性地被一个到四个独立选自R5、R6、R7和R8的相同或不同的组取代； J1、J2和J3每次出现时相同或不同，独立地选自-A1QA2-；Q是键、O、S、S(O)或S(O)2；A1和A2相同或不同，每次出现时独立地选自键、C1-3烷基、取代的C1-3烷基、C2-4烯基和取代的C2-4烯基，前提是A1和A2的选择使得环A是一个5至8成员的碳环或杂环； R1至R11如本文所述定义。 还提供了使用这些化合物的药物组合物和治疗炎性疾病、免疫相关疾病、肥胖和糖尿病的方法。
• Synthesis, stereochemistry, and rearrangement of thioxanthen-10-io-(bismethoxycarbonyl)methanides and their 9-alkyl derivatives
  作者：Yasumitsu Tamura、Chisato Mukai、Noriko Nakajima、Masazumi Ikeda、Masaru Kido

  DOI：10.1039/p19810000212

  日期：——

  Thioxanthen-10-io- and 2,4-dimethylthioxanthen-10-io-(bismethoxycarbonyl)methanides and their 9-alkyl derivatives were synthesised by the reaction of the corresponding thioxanthens with bismethoxycarbonylcarbene generated thermally from dimethyl diazomalonate in the presence of copper(II) sulphate. The stereochemistry of the ylides was determined by examination of the n.m.r. spectra and by X-ray analysis

  噻吨-10- IO-和2,4- dimethylthioxanthen -10- IO-（bismethoxycarbonyl）methanides及其9-烷基衍生物通过用从在铜的存在下二甲基diazomalonate热产生bismethoxycarbonylcarbene相应thioxanthens的反应合成（II）硫酸盐。通过检查核磁共振谱和通过反式的X射线分析确定叶立德的立体化学-9-乙基-2,4-二甲基噻吨黄-10--10-（双甲氧基羰基）甲烷。在存在1,8-二氮杂双环[5.4.0]十一碳-7-烯（DBU）的情况下，将甲苯磺酸flu回流在甲苯中会导致重排成相应的9-（双甲氧基羰基甲基）噻吨，但9-异丙基衍生物除外。即使在回流的二甲苯中也很稳定。讨论了重排的机制。
• TETRONIC AND TETRAMIC ACIDS
  申请人：Godel Thierry

  公开号：US20080132562A1

  公开（公告）日：2008-06-05

  This invention relates to new tetronic and tetramic acid derivatives with beta-secretase inhibitory activity of formula I: wherein R1, R2, R3, R4, R5, R5′, R6 and R6′ are as defined hereinabove, to processes for their preparation, compositions containing said tetronic and tetramic acid derivatives and their use in the treatment and prevention of diseases modulated by an inhibitor of β-secretase, such as Alzheimer's disease.

  本发明涉及一种新的具有β-分泌酶抑制活性的四元酸和四元酰胺衍生物，其化学式为I：其中R1、R2、R3、R4、R5、R5'、R6和R6'如上所定义，以及其制备过程、含有所述四元酸和四元酰胺衍生物的组合物以及它们在治疗和预防由β-分泌酶抑制剂调节的疾病，如阿尔茨海默病等方面的用途。
• COMPOUND, COMPOSITION FOR FORMING ORGANIC FILM, SUBSTRATE FOR MANUFACTURING SEMICONDUCTOR APPARATUS, METHOD FOR FORMING ORGANIC FILM, AND PATTERNING PROCESS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3550362A1

  公开（公告）日：2019-10-09

  The present invention provides a compound including two or more partial structures shown by the following general formula (1-1) in the molecule, wherein each Ar independently represents an aromatic ring optionally having a substituent or an aromatic ring that contains at least one nitrogen atom optionally having a substituent, and two Ars are optionally bonded with each other to form a ring structure; the broken line represents a bond with an organic group; B represents an anionic leaving group that is capable of forming a reactive cation due to effect of either or both of heat and acid. This provides a compound that is capable of curing under the film forming conditions in air or an inert gas without forming byproducts, and forming an organic under layer film that has good dry etching durability during substrate processing not only excellent characteristics of gap filling and planarizing a pattern formed on a substrate.

  本发明提供了一种化合物，其分子中包括两个或两个以上通式（1-1）所示的部分结构、 其中，每个 Ar 独立地代表一个可选具有取代基的芳香环或一个包含至少一个可选具有取代基的氮原子的芳香环，并且两个 Ar 可选地相互键合以形成环状结构；断线代表与一个有机基团的键合；B 代表一个阴离子离去基团，该离去基团能够在热和酸中的一种或两种作用下形成活性阳离子。这种化合物能够在空气或惰性气体中的成膜条件下固化而不产生副产物，并且在基底加工过程中形成的有机底层膜具有良好的干蚀刻耐久性，同时还具有填充间隙和使基底上形成的图案平面化的优异特性。
• ORGANIC ELECTROLUMINESCENT ELEMENT AND SPIRO COMPOUND FOR ORGANIC ELECTROLUMINESCENT ELEMENT
  申请人：Samsung Display Co., Ltd.

  公开号：EP3882997A1

  公开（公告）日：2021-09-22

  An organic electroluminescence device of an embodiment includes a first electrode, a hole transport region disposed on the first electrode, an emission layer disposed on the hole transport region, an electron transport region disposed on the emission layer and a second electrode disposed on the electron transport region, wherein the emission layer includes a spiro compound containing an aryl amine group and an indenoindole derivative, thereby showing high emission efficiency and emitting green light.

  一个实施例中的有机电致发光器件包括第一电极、设置在第一电极上的空穴传输区、设置在空穴传输区上的发射层、设置在发射层上的电子传输区和设置在电子传输区上的第二电极，其中发射层包括含有芳基胺基团和茚并吲哚衍生物的螺环化合物，从而显示出高发射效率并发出绿光。