2-methyl-imidazo[1,2-c]quinazoline | 52747-78-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-methyl-imidazo[1,2-c]quinazoline
• 英文别名: 2-Methylimidazo[1,2-c]quinazoline
• CAS: 52747-78-1
• 化学式: C₁₁H₉N₃
• 分子量: 183.213
• InChiKey: FVHVCTYLHFIYCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-imidazo[1,2-c]quinazoline 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以79.1%的产率得到2-Methyl-5,6-dihydro-imidazo[1,2-c]quinazoline
  参考文献：
  名称：

  Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect

  摘要：

  A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe(2+)-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80007-x
• 作为产物：
  描述：

  2-methyl-2,3-dihydro-imidazo[1,2-c]quinazoline 以78%的产率得到
  参考文献：
  名称：

  CLAUDI F.; FRANCHETTI P.; GRIFANTINI M.; MARTELLI S., J. ORG. CHEM. , 1974, 39, NO 24, 3508-3511

  摘要：

  DOI：

文献信息

• METAL COMPLEXES
  申请人：Merck Patent GmbH

  公开号：US20170309832A1

  公开（公告）日：2017-10-26

  The present invention relates to metal complexes and to electronic devices, in particular organic electroluminescent devices, comprising these metal complexes.
• Imidazo[1,2-c]quinazolines with lipid peroxidation inhibitory effect
  作者：György Domány、Tibor Gizur、Anikó Gere、Krisztina Takács-Novák、György Farsang、György G. Ferenczy、Gábor Tárkányi、Mária Demeter

  DOI：10.1016/s0223-5234(98)80007-x

  日期：1998.3

  A series of imidazo[1,2-c]quinazolines of different lipophilic character was prepared. According to their antioxidant (cyclic voltammetry) properties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe(2+)-induced lipid peroxidation in rat brain homogenate), however, their lipid peroxidation inhibitory activity was strongly dependent on their lipophilicity. (C) Elsevier, Paris.
• CLAUDI F.; FRANCHETTI P.; GRIFANTINI M.; MARTELLI S., J. ORG. CHEM. <JOCE-AH>, 1974, 39, NO 24, 3508-3511
  作者：CLAUDI F.、 FRANCHETTI P.、 GRIFANTINI M.、 MARTELLI S.

  DOI：——

  日期：——