(E)-2,2,6,6-tetramethyl-1-((4-phenyl-3-(o-tolyl)but-3-en-2-yl)oxy)piperidine | 1607843-49-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-2,2,6,6-tetramethyl-1-((4-phenyl-3-(o-tolyl)but-3-en-2-yl)oxy)piperidine
• 英文别名: 2,2,6,6-tetramethyl-1-[(E)-3-(2-methylphenyl)-4-phenylbut-3-en-2-yl]oxypiperidine
• CAS: 1607843-49-1
• 化学式: C₂₆H₃₅NO
• 分子量: 377.57
• InChiKey: KAUGPDLZQPFLFN-CLCOLTQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,2,6,6-四甲基哌啶氧化物 、 丁-1,2-二烯基苯 、 2-甲基苯硼酸 在 manganese(IV) oxide 、 copper(II) bis(trifluoromethanesulfonate) 、 (S,S)-(-)-2,2'-异亚丙基双(4-叔丁基-2-恶唑啉) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以92%的产率得到(E)-2,2,6,6-tetramethyl-1-((4-phenyl-3-(o-tolyl)but-3-en-2-yl)oxy)piperidine
  参考文献：
  名称：

  Copper-Catalyzed Regio- and Stereoselective Intermolecular Three-Component Oxyarylation of Allenes

  摘要：

  A copper(II)-catalyzed intermolecular three-component oxyarylation of allenes using arylboronic acids as a carbon source and TEMPO as an oxygen source is described. The reaction proceeded under mild conditions with high regio- and stereo-selectivity and functional group tolerance. A plausible reaction mechanism is proposed, involving carbocupration of allenes, homolysis of the intervening allylcopper(II), and a radical TEMPO trap.

  DOI：

  10.1021/ol501022d

文献信息

• Copper-Catalyzed Regio- and Stereoselective Intermolecular Three-Component Oxyarylation of Allenes
  作者：Taisuke Itoh、Yohei Shimizu、Motomu Kanai

  DOI：10.1021/ol501022d

  日期：2014.5.16

  A copper(II)-catalyzed intermolecular three-component oxyarylation of allenes using arylboronic acids as a carbon source and TEMPO as an oxygen source is described. The reaction proceeded under mild conditions with high regio- and stereo-selectivity and functional group tolerance. A plausible reaction mechanism is proposed, involving carbocupration of allenes, homolysis of the intervening allylcopper(II), and a radical TEMPO trap.