Efficient synthesis of benzothieno[3,2-<i>d</i>]-1,2,4-triazolo [1,5-<i>a</i>]pyrimidin-5(1<i>H</i>)-ones<i>via</i>a tandem aza-Wittig/heterocumulene-mediated annulation
作者:Sheng-Zhen Xu、Min-Hui Cao、Chang-Shui Chen、Ming-Wu Ding
DOI:10.1002/jhet.158
日期:2009.9
with hydrazine to give selectively 3-amino-2-arylaminobenzothieno[3,2-d]pyrimidin-4(3H)-ones . Reactions of with triphenylphosphine, hexachloroethane, and Et3N produced iminophosphoranes . A tandem aza-Wittig reaction of iminophosphorane with isocyanate, acyl chloride generated benzothieno[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5(1H)-ones and in satisfactory yields. The effects of the nucleophiles on
碳二亚胺 ,由亚氨基磷烷反应制得 与异氰酸酯反应,与肼反应,选择性地生成3-氨基-2-芳基氨基苯并噻吩并[3,2- d ]嘧啶-4(3 H)-ones。的反应与三苯膦,六氯乙烷和Et 3 N生成的亚氨基正膦。亚氨基磷烷的串联氮杂-维蒂希反应与异氰酸酯一起生成酰氯,生成苯并噻吩并[3,2- d ] -1,2,4-三唑并[1,5- a ]嘧啶-5(1 H)-ones 和 产量令人满意。已经研究了亲核试剂对环化的影响。J.杂环化学,(2009)。