ZRL5 | 1191923-45-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ZRL5
• 英文别名: (4-nitrophenyl) N-[[4-(3-chloroanilino)quinazolin-6-yl]diazenyl]-N-methylcarbamate
• CAS: 1191923-45-1
• 化学式: C₂₂H₁₆ClN₇O₄
• 分子量: 477.867
• InChiKey: VELJECLRZJJJQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  138
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  BJ 2000 、 对硝基苯基氯甲酸酯 在 吡啶 作用下， 以 乙腈 为溶剂， 生成 ZRL5
  参考文献：
  名称：

  Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2

  摘要：

  The monoalkyltriazene moiety lends itself well to the design of combi-molecules. However, due to its instability under physiological conditions, efforts were directed towards stabilizing it by grafting a hydrolysable carbamate onto the 3-position. The synthesis and biological activities of these novel N-carbamyl triazenes are described. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.05.060

文献信息

• Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2
  作者：Zakaria Rachid、Meaghan MacPhee、Christopher Williams、Margarita Todorova、Bertrand Jacques Jean-Claude

  DOI：10.1016/j.bmcl.2009.05.060

  日期：2009.9

  The monoalkyltriazene moiety lends itself well to the design of combi-molecules. However, due to its instability under physiological conditions, efforts were directed towards stabilizing it by grafting a hydrolysable carbamate onto the 3-position. The synthesis and biological activities of these novel N-carbamyl triazenes are described. (C) 2009 Elsevier Ltd. All rights reserved.