3-(7-nitro-3,4-dihydroimidazo[4,5-b]indol-2-yl)-7-hydroxy-4H-chromen-4-one | 943965-76-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3-(7-nitro-3,4-dihydroimidazo[4,5-b]indol-2-yl)-7-hydroxy-4H-chromen-4-one
• 英文别名: 7-Hydroxy-3-(7-nitro-1,4-dihydroimidazo[4,5-b]indol-2-yl)chromen-4-one
• CAS: 943965-76-2
• 化学式: C₁₈H₁₀N₄O₅
• 分子量: 362.301
• InChiKey: ONPSWKWZJFYPKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-(7-nitro-3,4-dihydroimidazo[4,5-b]indol-2-yl)-7-hydroxy-4H-chromen-4-one 在 18-冠醚-6 、 zinc diacetate 、 potassium carbonate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 12.0h， 生成 3-(7-nitro-3,4-dihydroimidazo[4,5-b]indol-2-yl)-7-(β-D-glucopyranosyloxy)-4H-chromen-4-one
  参考文献：
  名称：

  Synthesis ofO‐β‐D‐Glucopyranosides of 7‐Hydroxy‐3‐(imidazol‐2‐yl)‐4H‐chromen‐4‐ones

  摘要：

  The 7-hydroxy-3-formyl-4H-chromen-4-one 1 reacted with various cyclic 1,2-dicarbonyl compounds in the presence of ammonium acetate to furnish 7-hydroxy-3-([4,5-fused] imidazol-2-yl)-4H-chromen-4-ones 2a-f, which on glucosylation with alpha-acetobromoglucose affords 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy-3-([4,5-fused]-imidazol-2-yl)-4H-chromen-4-ones3a-f. 7-O-beta-D-Glucopyranosyloxy-3-([4,5-fused]-imidazol-2-yl)-4H- chromen-4-ones4a-f were prepared by deacetylation with anhydrous zinc acetate in absolute methanol. The structure of these new O-beta-D-glucosides was established on the basis of chemical, elemental, and spectral analysis. These compounds were evaluated for their in vitro biological activity.[GRAPHICS]

  DOI：

  10.1080/07328300701298196
• 作为产物：
  描述：

  7-羟基-4-氧代-4H-1-苯并吡喃-3-羧醛 、 5-硝基靛红 在 乙酸铵 、 溶剂黄146 作用下， 反应 2.0h， 以65%的产率得到3-(7-nitro-3,4-dihydroimidazo[4,5-b]indol-2-yl)-7-hydroxy-4H-chromen-4-one
  参考文献：
  名称：

  Synthesis ofO‐β‐D‐Glucopyranosides of 7‐Hydroxy‐3‐(imidazol‐2‐yl)‐4H‐chromen‐4‐ones

  摘要：

  The 7-hydroxy-3-formyl-4H-chromen-4-one 1 reacted with various cyclic 1,2-dicarbonyl compounds in the presence of ammonium acetate to furnish 7-hydroxy-3-([4,5-fused] imidazol-2-yl)-4H-chromen-4-ones 2a-f, which on glucosylation with alpha-acetobromoglucose affords 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy-3-([4,5-fused]-imidazol-2-yl)-4H-chromen-4-ones3a-f. 7-O-beta-D-Glucopyranosyloxy-3-([4,5-fused]-imidazol-2-yl)-4H- chromen-4-ones4a-f were prepared by deacetylation with anhydrous zinc acetate in absolute methanol. The structure of these new O-beta-D-glucosides was established on the basis of chemical, elemental, and spectral analysis. These compounds were evaluated for their in vitro biological activity.[GRAPHICS]

  DOI：

  10.1080/07328300701298196

文献信息

• Synthesis of<i>O</i>‐β‐<scp>D</scp>‐Glucopyranosides of 7‐Hydroxy‐3‐(imidazol‐2‐yl)‐4<i>H‐</i>chromen‐4‐ones
  作者：V. N. Ingle、K. M. Hatzade、V. S. Taile、P. K. Gaidhane、S. T. Kharche

  DOI：10.1080/07328300701298196

  日期：2007.4.30

  The 7-hydroxy-3-formyl-4H-chromen-4-one 1 reacted with various cyclic 1,2-dicarbonyl compounds in the presence of ammonium acetate to furnish 7-hydroxy-3-([4,5-fused] imidazol-2-yl)-4H-chromen-4-ones 2a-f, which on glucosylation with alpha-acetobromoglucose affords 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy-3-([4,5-fused]-imidazol-2-yl)-4H-chromen-4-ones3a-f. 7-O-beta-D-Glucopyranosyloxy-3-([4,5-fused]-imidazol-2-yl)-4H- chromen-4-ones4a-f were prepared by deacetylation with anhydrous zinc acetate in absolute methanol. The structure of these new O-beta-D-glucosides was established on the basis of chemical, elemental, and spectral analysis. These compounds were evaluated for their in vitro biological activity.[GRAPHICS]