o-hydroxyphenyl isothiocyanate | 86695-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: o-hydroxyphenyl isothiocyanate
• 英文别名: 2-hydroxyphenylisothiocyanate；2-Isothiocyanatophenol
• CAS: 86695-08-1
• 化学式: C₇H₅NOS
• 分子量: 151.189
• InChiKey: BUFAYFTZUOIEBA-UHFFFAOYSA-N

物化性质

• 熔点：
  145 °C
• 沸点：
  278.0±23.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  o-hydroxyphenyl isothiocyanate 在 indium(III) chloride 作用下， 以 氯苯 为溶剂， 反应 4.5h， 以93%的产率得到4-苯并噻唑
  参考文献：
  名称：

  一种聚碳酸酯抗高温降解剂的制备方法及一种聚碳酸酯组合物

  摘要：

  本发明提供了一种聚碳酸酯抗高温降解剂的制备方法及一种聚碳酸酯组合物，采用铟催化剂制备的抗高温降解剂的结构通式如下：，本发明制备方法简单、操作方便，并且产物易于提纯、收率高，可避免在聚碳酸酯组合物中引入杂质；该物质在空气氛围及高温条件下具有良好的抗高温降解能力，并且有利于节省聚碳酸酯组合物的生产成本。

  公开号：

  CN114516848A

文献信息

• Synthesis and biological activity of some triazole-bearing benzimidazole derivatives
  作者：K.F. Ansari、C. Lal、R.K. Khitoliya

  DOI：10.2298/jsc100301029a

  日期：——

  A number of N'-[(aryl)methylidene]-2-(2-methyl-1H-benzimidazol- 1-yl)acetohydrazide and 4-(aryl)-5-[(2-methyl-1H-benzimidazol- 1-yl)methyl]-4H-1,2,4-triazole-3-thiol derivatives were synthesized by incorporating various aromatic and heterocyclic substituents on 2-methyl-1H-benzimidazole. The structures of all the synthesized compounds were elucidated based on their elemental analyses and spectral data. The in vitro activities of these compounds against bacteria and fungi were evaluated by the disc diffusion and the minimum inhibitory concentration (MIC) methods. Some of the synthesized derivatives were found to be as active as kanamycin (standard drug).

  一些 N'-[（芳基）亚甲基]-2-（2-甲基-1H-苯并咪唑- 1-基)乙酰肼和 4-(芳基)-5-[(2-甲基-1H-苯并咪唑- 1-基)甲基]-4H-1,2,4-三唑-3-硫醇衍生物的合成。 在 2-甲基-1H-苯并咪唑-1-基上加入各种芳香族和杂环取代基，合成了 2-甲基-1H-苯并咪唑。所有合成化合物的结构 根据元素分析和光谱数据阐明了所有合成化合物的结构。这些化合物的 对细菌和真菌的体外活性进行了评估。 盘扩散法和最低抑菌浓度 (MIC) 法评估了这些化合物对细菌和真菌的体外活性。 发现一些合成衍生物的活性与卡那霉素（标准药物）相当。 (标准药物）一样有效。
• [EN] GUANIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF<br/>[FR] DERIVES DE LA GUANIDINE ET UTILISATIONS THERAPEUTIQUES DE CEUX-CI
  申请人：MERCK PATENT GMBH

  公开号：WO2006010422A1

  公开（公告）日：2006-02-02

  Compounds of the formula (I) in which the radicals R and R1 to R10 are as defined in the description, processes for the preparation of them, use thereof for the treatment of cardiovascular diseases, and pharmaceutical compositions comprising them.

  式（I）中的化合物，其中基团R和R1至R10的定义如描述中所定义，它们的制备方法，用于治疗心血管疾病的用途，以及包含它们的药物组合物。
• Synthesis, characterization, and biological evaluation of new N-glycosides derived from O-pivaloylated β-d-glucopyranosylamine
  作者：Chao Shen、Guobin Zhou、Xinzhi Chen、Pengfei Zhang

  DOI：10.1007/s11164-011-0423-7

  日期：2012.3

  The novel synthesis of N-(2,3,4,6-tetra-O-pivaloyl-β-d-glucopyranosyl) benzo[d] oxazol-2-amine 4 was described in this study. The new compounds N-arylthioureas 3a-c and 4, along with a series of glucose-modified imines 5a-g, were evaluated for their antitumor activity against human myeloid leukemia cell lines (HL-60 cells), gastric carcinoma (BGC-823 cells), liver carcinoma (Bel-7402 cells), and oral carcinomas (KB cells). The antibacterial potency of these compounds was also determined using an inhibition zone diameter test. Although none of the compounds were active against human cancer cells, compound 4 was found to be the most active compound against Escherichia coli.

  本研究描述了 N-(2,3,4,6-四-O-特戊酰基-β-d-吡喃葡萄糖基) 苯并[d] 恶唑-2-胺 4 的新型合成方法。研究人员评估了新化合物 N-芳基硫脲类 3a-c 和 4 以及一系列葡萄糖修饰亚胺 5a-g 对人类髓性白血病细胞系（HL-60 细胞）、胃癌细胞系（BGC-823 细胞）、肝癌细胞系（Bel-7402 细胞）和口腔癌细胞系（KB 细胞）的抗肿瘤活性。这些化合物的抗菌效力也是通过抑菌区直径测试确定的。虽然没有一种化合物对人类癌细胞有活性，但发现化合物 4 是对大肠杆菌最有活性的化合物。
• Guanidine Derivatives and Therapeutic Uses Thereof
  申请人：Roche Didier

  公开号：US20080004315A1

  公开（公告）日：2008-01-03

  Compounds of the formula (I): in which the radicals R and R 1 to R 10 are as defined in the description, processes for the preparation of them, use thereof for the treatment of cardiovascular diseases, and pharmaceutical compositions comprising them.

  式(I)的化合物：其中基团R和R1至R10如描述中所定义，它们的制备过程，它们用于治疗心血管疾病的用途，以及包含它们的药物组合物。
• Compositions for repelling crawling insects
  申请人：——

  公开号：US20020094993A1

  公开（公告）日：2002-07-18

  The present invention relates to novel compositions, comprising a repellent and an additive, where the additive is selected from the group consisting of phenol, benzaldehyde, benzoic acid or derivatives thereof and is present in a ratio of from 10:100 to 200:100% by weight to the repellent, and to their use for repelling crawling harmful insects, in particular ants or cockroaches.

  本发明涉及新型组合物，包括一种驱虫剂和一种添加剂，其中所述添加剂选自苯酚、苯甲醛、苯甲酸或其衍生物组成的群体，并以10:100至200:100％重量的比例存在于驱虫剂中，以及其用于驱赶爬行有害昆虫，特别是蚂蚁或蟑螂。