1-(t-Butoxymethyl)naphthalin | 63261-33-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(t-Butoxymethyl)naphthalin
• 英文别名: 1-(tert-butoxymethyl)naphthalene；tert-butyl-[1]naphthylmethyl ether；tert-Butyl-[1]naphthylmethyl-aether；1-t-butoxymethylnaphthalene；1-[(2-methylpropan-2-yl)oxymethyl]naphthalene
• CAS: 63261-33-6
• 化学式: C₁₅H₁₈O
• 分子量: 214.307
• InChiKey: BMNYXDKLEARVEL-UHFFFAOYSA-N

物化性质

• 沸点：
  158-160 °C(Press: 12 Torr)
• 密度：
  1.009±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(t-Butoxymethyl)naphthalin 以80%的产率得到1-萘甲醛
  参考文献：
  名称：

  Method for production of aldehydes

  摘要：

  以下是该公式的中文翻译： 其中Ra是氢原子、烃基或杂环基，Rb是氢原子、羟基或取代氧基，Rc是烃基或杂环基；Ra和Rc可以结合形成与相邻碳原子和氧原子的环。在以下公式（1）所示的亚胺化合物组成的催化剂存在下，将具有以下公式（2）的醚与一氧化氮反应： 其中R1和R2中的每一个，与彼此相同或不同，是氢原子、卤素原子、烷基、芳基、环烷基、羟基、烷氧基、羧基、烷氧羰基或酰基；R1和R2可以结合形成双键，或芳香或非芳香环；X是氧原子或羟基；在公式（1）中指示的一个或两个N-取代的环亚胺基团还可以进一步形成在R1、R2上，或者在由R1和R2共同形成的双键或芳香或非芳香环上）以得到以下公式（3）的醛： Ra—CHO（3） （其中Ra的含义与上文定义的相同）。

  公开号：

  US06201156B1
• 作为产物：
  描述：

  叔丁氧甲基三氟硼酸钾 、 达泊西汀杂质42 在 potassium phosphate 、 dichloro(cycloocta-1,5-diene)palladium (II) 、 1,1'-bis(diisopropylphosphino)ferrocene 作用下， 以 水 、 叔丁醇 为溶剂， 反应 20.0h， 以87%的产率得到1-(t-Butoxymethyl)naphthalin
  参考文献：
  名称：

  Cross-Coupling of Mesylated Phenol Derivatives with Potassium Alkoxymethyltrifluoroborates

  摘要：

  Cross-coupling of mesylated phenol derivatives with various potassium alkoxymethyltrifluoroborates has been achieved. The corresponding aryl and heteroaryl alkoxymethyl compounds have been obtained with equal facility with both electron-rich and electron-poor substituents on the activated alcohol.

  DOI：

  10.1021/ol201469r

文献信息

• PSEUDONUCLEOTIDE COMPRISING AN INTERCALATOR
  申请人：Christensen Ulf Bech

  公开号：US20100121056A1

  公开（公告）日：2010-05-13

  The present invention relates to intercalator pseudonucleotides. Intercalator pseudonucleotides according to the invention are capable of being incorporated into the backbone of a nucleic acid or nucleic acid analogue and they comprise an intercalator comprising a flat conjugated system capable of co-stacking with nucleobases of DNA. The invention also relates to oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudo nucleotide. The invention furthermore relates to methods of synthesising intercalator pseudo nucleotides and methods of synthesising oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudonucleotide. In addition, the invention describes methods of separating sequence specific DNA(s) from a mixture comprising nucleic acids, methods of detecting a sequence specific DNA (target DNA) in a mixture comprising nucleic acids and/or nucleic acid analogues and methods of detecting a sequence specific RNA in a mixture comprising nucleic acids and/or nucleic acid analogues. In particular said methods may involve the use of oligonucleotides comprising intercalator pseudo nucleotides. The invention furthermore relates to pairs of oligonucleotides or oligonucleotide analogues capable of hybridising to one another, wherein said pairs comprise at least one intercalator pseudonucleotide. Methods for inhibiting a DNAse and/or a RNAse and methods of modulating transcription of one or more specific genes are also described.

  本发明涉及插入剂伪核苷酸。本发明的插入剂伪核苷酸能够被合并到核酸或核酸类似物的骨架中，并且它们包括一个插入剂，该插入剂包含一个平面共轭系统，能够与DNA的碱基共堆叠。本发明还涉及至少包括一个插入剂伪核苷酸的寡核苷酸或寡核苷酸类似物。此外，本发明还涉及合成插入剂伪核苷酸的方法以及合成至少包括一个插入剂伪核苷酸的寡核苷酸或寡核苷酸类似物的方法。此外，本发明还描述了从包括核酸的混合物中分离序列特异性DNA的方法，检测包括核酸和/或核酸类似物的混合物中的序列特异性DNA（目标DNA）的方法，以及检测包括核酸和/或核酸类似物的混合物中的序列特异性RNA的方法。特别是所述方法可能涉及使用包括插入剂伪核苷酸的寡核苷酸。本发明还涉及能够杂交到一起的寡核苷酸或寡核苷酸类似物的配对，其中所述配对包括至少一个插入剂伪核苷酸。还描述了抑制DNA酶和/或RNA酶的方法以及调节一个或多个特定基因的转录的方法。
• SMALL MOLECULE INHIBITORS OF MCL-1 AND USES THEREOF
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20150045357A1

  公开（公告）日：2015-02-12

  This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a [(1-Piperazinyl)-4-pyridinylmethyl]-Naphtho[1,2-b]furan structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

  这项发明属于药物化学领域。具体而言，该发明涉及一类新型小分子，具有[(1-哌嗪基)-4-吡啶甲基]-萘[1,2-b]呋喃结构，能够作为Mcl-1蛋白质的抑制剂，并且它们被用作治疗癌症和其他疾病的治疗药物。
• A New Approach for Oxygenation Using Nitric Oxide under the Influence of <i>N</i>-Hydroxyphthalimide
  作者：Masahiro Eikawa、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1021/jo982406o

  日期：1999.6.1

  An approach for partial oxygenation through a carbocation as an intermediate was successfully developed by using nitric oxide under the influence of N-hydroxyphthalimide. Thus, a variety of benzylic ethers were converted into the corresponding partially oxidized compounds, which are difficult to prepare by conventional methods, in high yields. For example, the reaction of phthalane with NO in the presence of a catalytic amount of NHPI at 60 degrees C gave phthalaldehyde in 80% yield. The reaction was found to proceed through the formation of a hemiacetal, such as 1-hydroxyphthalane. In addition, 1,3-di-tert-butoxymethyl benzene afforded 1,3-benzenedicarbaldehyde in good yield. On the other hand, isochroman was converted into 1,1'-oxodiisochromane under these reaction conditions. The reaction of ethers with NO in the presence of a NHPI catalyst is thought to proceed via the formation of a carbocation as an intermediate. A possible reaction path was suggested.
• BANWELL M. G.; BLATTNER R.; BROWNE A. R.; CRAIG J. T.; HALTON B., J. CHEM. SOC. PERKIN TRANS., PART 1 <JCPK-BH>, 1977, NO 19, 2165-2168
  作者：BANWELL M. G.、 BLATTNER R.、 BROWNE A. R.、 CRAIG J. T.、 HALTON B.

  DOI：——

  日期：——
• OLIGONUCLEOTIDES COMPRISING SIGNALLING PAIRS AND HYDROPHOBIC NUCLEOTIDES, STEMLESS BEACONS, FOR DETECTION OF NUCLEIC ACIDS, METHYLATION STATUS AND MUTANTS OF NUCLEIC ACIDS
  申请人：Christensen Ulf Bech

  公开号：US20100068704A1

  公开（公告）日：2010-03-18

  The invention relates to novel oligonucleotides comprising a signalling pair and at least hydrophobic nucleotide. The oligonucleotide analogues are useful for detecting the status of nucleic acid sequences, such as presence, expression, methylation and/or mutation, in particular single point mutations and other sequences where the variation between the correct target and other targets may vary in as little as one nucleotide. The invention also relates to new ways of detecting sequence differences and optimizing conditions by using oligonucleotide analogues and readily available instruments. In particular the invention relates to specifically detecting quantity of a target nucleic acids or detecting one sequence over others that may vary in as little as one nucleotide using oligonucleotides or oligonucleotide analogues comprising a signalling pair and at least one hydrophobic nucleotide, such as a nucleotide analogue comprising an intercalator.