2-Amino-3-Chlor-5,8-dimethoxy-1,4-naphthochinon | 71026-19-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Amino-3-Chlor-5,8-dimethoxy-1,4-naphthochinon
• 英文别名: 2-Amino-3-chloro-5,8-dimethoxynaphthalene-1,4-dione
• CAS: 71026-19-2
• 化学式: C₁₂H₁₀ClNO₄
• 分子量: 267.669
• InChiKey: QSXYVXFIEVNJOB-UHFFFAOYSA-N

物化性质

• 熔点：
  247-249 °C
• 沸点：
  454.4±45.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  78.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-Amino-3-Chlor-5,8-dimethoxy-1,4-naphthochinon 在 sodium sulfide 作用下， 以 水 为溶剂， 反应 0.83h， 生成 2-mercapto-3-amino-5,8-dimethoxy-1,4-naphthoquinone
  参考文献：
  名称：

  Synthesis, antileukemic evaluation and peroxidating ability of heterosubstituted anthracene-9,10-dione analogues: 5,8-[(aminoalkyl)amino]naphtho[2,3-d]thiazole-4,9-diones and 5,8-[(aminoalkyl)amino]naphtho[2,3-c] [1,2,5]thiadiazole-4,9-diones

  摘要：

  The syntheses of a number of heterosubstituted ametantrone analogues, 5,8-bis[(aminoalkyl)amino]naphtho[2,3-d]thia- zole-4,9-diones and 5,8-bis[(aminoalkyl)amino]naphtho[2,3-c] [1,2,5]thiadiazole-4,9-diones, have been performed. It was evidenced that this modification in the chromophore moiety has a negative effect on antileukemic activity. This modification also favors the affinity of the compounds toward NADH dehydrogenase and influences the redox potential.

  DOI：

  10.1016/0223-5234(94)90148-1
• 作为产物：
  描述：

  2,3-dichloro-5,8-dimethoxynaphthalene-1,4-dione 在 ammonium hydroxide 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 6.0h， 以37%的产率得到2-Amino-3-Chlor-5,8-dimethoxy-1,4-naphthochinon
  参考文献：
  名称：

  取代的3-氯-5,8-二甲氧基-1,4-萘醌和相关化合物的合成及其抗血小板，抗炎和抗过敏活性。

  摘要：

  铅化合物2,3-二氯-苯并（2-）合成了5,8-二甲氧基-1,4-萘醌（4）和6,7-二氯-5,8-二甲氧基-1,4-萘醌（5），它是4的位置异构体。抗血小板，抗炎和抗过敏对活性进行了评估，大多数化合物在所有测定中均非常有效。化合物5和9-11具有特别的活性。然而，有5个对嗜中性白细胞超氧化物的形成无效，而10个对肥大细胞脱粒无效。

  DOI：

  10.1016/s0968-0896(98)80006-0

文献信息

• GREEN-BUCKLEY G.; GRIFFITHS J., J. CHEM. SOC. PERKIN TRANS., PART 1, 1979, NO 3, 702-707
  作者：GREEN-BUCKLEY G.、 GRIFFITHS J.

  DOI：——

  日期：——
• RADICAL POLYMERIZATION CONTROL AGENT AND RADICAL POLYMERIZATION CONTROL METHOD
  申请人：Kawasaki Kasei Chemicals Ltd.

  公开号：US20210122692A1

  公开（公告）日：2021-04-29

  A conventional polymerization inhibitor is for example an agent to scavenge radicals generated during storage of a radical polymerizable compound and used to stably handle the radical polymerizable compound, but is unnecessary when the radical polymerizable compound is to be subjected to radical polymerization reaction, and is preferably removed at the time of the radical polymerization reaction. The object of the present invention is to obviate inconvenience of removing the polymerization inhibitor at the time of radical polymerization. The radical polymerization control agent contained in a radical polymerizable composition of the present invention functions as a radical polymerization inhibitor for example stored in a dark place, but loses its radical polymerization inhibiting effect when polymerization is initiated while being irradiated with light at a certain specific wavelength at the time of polymerization. Thus, radical polymerization of the radical polymerizable compound is easily initiated without increasing the amount of a radical polymerization initiator. That is, the radical polymerization control agent of the present invention is a radical polymerization control agent which is a corn pound having an effect to inhibit radical polymerization of a radical polymerizable compound and which loses the radical polymerization inhibiting effect under irradiation with light rays containing light within a wavelength range of from 300 nm to 500 nm.
• Synthesis, antileukemic evaluation and peroxidating ability of heterosubstituted anthracene-9,10-dione analogues: 5,8-[(aminoalkyl)amino]naphtho[2,3-d]thiazole-4,9-diones and 5,8-[(aminoalkyl)amino]naphtho[2,3-c] [1,2,5]thiadiazole-4,9-diones
  作者：M Dzieduszycka、B Stefańska、J Tarasiuk、S Martelli、M Bontemps-Gracz、E Borowski

  DOI：10.1016/0223-5234(94)90148-1

  日期：1994.1

  The syntheses of a number of heterosubstituted ametantrone analogues, 5,8-bis[(aminoalkyl)amino]naphtho[2,3-d]thia- zole-4,9-diones and 5,8-bis[(aminoalkyl)amino]naphtho[2,3-c] [1,2,5]thiadiazole-4,9-diones, have been performed. It was evidenced that this modification in the chromophore moiety has a negative effect on antileukemic activity. This modification also favors the affinity of the compounds toward NADH dehydrogenase and influences the redox potential.
• Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of substituted 3-chloro-5,8-dimethoxy-1,4-naphthoquinone and related compounds
  作者：Li-Jiau Huang、Fu-Chaio Chang、Kuo-Hsiung Lee、Jih-Pyang Wang、Che-Ming Teng、Sheng-Chu Kuo

  DOI：10.1016/s0968-0896(98)80006-0

  日期：1998.12

  and 5,8-diacetoxy (11) derivatives of the lead compound 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone (4) were synthesized, together with 6,7-dichloro-5,8dimethoxy-1,4-naphthoquinone (5), a positional isomer of 4. Antiplatelet, antiinflammatory, and antiallergic activities were evaluated, and most compounds were quite potent in all assays. Compounds 5 and 9-11 were especially active; however, 5 was

  铅化合物2,3-二氯-苯并（2-）合成了5,8-二甲氧基-1,4-萘醌（4）和6,7-二氯-5,8-二甲氧基-1,4-萘醌（5），它是4的位置异构体。抗血小板，抗炎和抗过敏对活性进行了评估，大多数化合物在所有测定中均非常有效。化合物5和9-11具有特别的活性。然而，有5个对嗜中性白细胞超氧化物的形成无效，而10个对肥大细胞脱粒无效。