N-β-dimethylaminoethylaziridine | 120626-66-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-β-dimethylaminoethylaziridine
• 英文别名: 2-(aziridin-1-yl)-N,N-dimethylethanamine
• CAS: 120626-66-6
• 化学式: C₆H₁₄N₂
• 分子量: 114.191
• InChiKey: NQTLWSUWTCIHBM-UHFFFAOYSA-N

物化性质

• 沸点：
  145-150 °C(Press: 1.5 Torr)
• 密度：
  0.934±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  6.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙烯亚胺 、 (2-溴甲基)二甲胺 在 氢氧化钾 作用下， 以 乙醚 为溶剂， 反应 12.0h， 以16%的产率得到N-β-dimethylaminoethylaziridine
  参考文献：
  名称：

  Oligomers of aziridines and N-?-aziridinoethylamides

  摘要：

  DOI：

  10.1007/bf00959886

文献信息

• [EN] HETEROARYL COMPOUNDS FOR KINASE INHIBITION<br/>[FR] COMPOSÉS HÉTÉROARYLE D'INHIBITION DE LA KINASE
  申请人：ARIAD PHARMA INC

  公开号：WO2015195228A1

  公开（公告）日：2015-12-23

  Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.

  调节激酶活性的化合物和药物组合物，包括突变的EGFR和突变的HER2激酶活性，以及与激酶活性相关的疾病和病况的治疗方法、化合物、药物组合物，包括突变的EGFR和突变的HER2活性，均在本文中描述。
• Adhesion promoting primer for coated surfaces
  申请人：Cordis Corporation

  公开号：EP2198814A2

  公开（公告）日：2010-06-23

  An implantable medical device comprises an intraluminal scaffold having a plurality of openings therein. A first coating comprising a material having a first electric charge is affixed to at least a portion of a surface of the intraluminal scaffold and a surface of the plurality of openings. A second coating comprising a material having a second electric charge is affixed to at least a portion of the first coating, the second electric charge being opposite of the first electric charge. At least one therapeutic agent is deposited in at least one of the plurality of openings, with the second coating acting as an intermediate layer between the first coating and the at least one therapeutic agent.

  一种可植入医疗设备包括一个腔内支架，支架上有多个开口。由具有第一电荷的材料组成的第一涂层粘附在腔内支架表面的至少一部分和多个开口的表面上。由具有第二电荷的材料组成的第二涂层粘附在第一涂层的至少一部分上，第二电荷与第一电荷相反。至少一种治疗剂沉积在多个开口中的至少一个开口中，第二涂层作为第一涂层和至少一种治疗剂之间的中间层。
• Adhesion promoting temporary mask for coated surfaces
  申请人：Cordis Corporation

  公开号：EP2201915A1

  公开（公告）日：2010-06-30

  A method of making an intraluminal medical device (10)(1206) having a plurality of openings (30) therein involves applying a mask (1202) to interior surfaces (1204) of a scaffold which has openings formed in it. A coating (1208) which includes an anti-thrombotic material is applied to the surfaces of the scaffold. The mask and any coating adhered to the mask are removed from the interior surfaces of the plurality of openings in the intraluminal scaffold. The openings are filled at least partially with one or more therapeutic agents (1210).

  一种制造具有多个开口（30）的腔内医疗器械（10）（1206）的方法包括在支架的内表面（1204）上涂抹掩膜（1202），支架上已形成开口。将包括抗血栓材料的涂层（1208）涂在支架表面。从腔内支架的多个开口的内表面去除掩膜和附着在掩膜上的涂层。用一种或多种治疗剂（1210）至少部分填充这些开口。
• Reservoir eluting stent
  申请人：Cordis Corporation

  公开号：EP2213264A1

  公开（公告）日：2010-08-04

  An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. Primer layers may be used to ensure that the different agents remain affixed to the device as well as to each other.

  一种可膨胀的医疗设备包括多个细长的支柱，形成一个可从第一直径膨胀到第二直径的基本圆柱形设备。可将多种不同的有益制剂装入支杆内的不同开口，以输送到组织中。在治疗再狭窄等疾病时，可将不同的药剂装入装置的不同开口，以解决再狭窄所涉及的不同生物过程，并以与所治疗的生物过程相匹配的不同释放动力学进行输送。不同的药剂也可用于通过同一给药装置治疗不同的疾病。此外，抗血栓药剂可粘附在医疗器械的至少部分表面，以预防亚急性血栓形成。底层可用于确保不同的药剂保持粘附在装置上以及相互粘附。
• ADHESION PROMOTING PRIMER FOR COATED SURFACES
  申请人：Cardinal Health Switzerland 515 GmbH

  公开号：EP3607915A1

  公开（公告）日：2020-02-12

  An implantable medical device comprises an intraluminal scaffold having a plurality of openings therein. A first coating comprising a material having a first electric charge is affixed to at least a portion of a surface of the intraluminal scaffold and a surface of the plurality of openings. A second coating comprising a material having a second electric charge is affixed to at least a portion of the first coating, the second electric charge being opposite of the first electric charge. At least one therapeutic agent is deposited in at least one of the plurality of openings, with the second coating acting as an intermediate layer between the first coating and the at least one therapeutic agent.

  一种可植入医疗设备包括一个腔内支架，支架上有多个开口。由具有第一电荷的材料组成的第一涂层粘附在腔内支架表面的至少一部分和多个开口的表面上。由具有第二电荷的材料组成的第二涂层粘附在第一涂层的至少一部分上，第二电荷与第一电荷相反。至少一种治疗剂沉积在多个开口中的至少一个开口中，第二涂层作为第一涂层和至少一种治疗剂之间的中间层。