3-(3-茚基)-1-丙醇 | 37848-93-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 中文名称: 3-(3-茚基)-1-丙醇
• 英文名称: 3-(3-indenyl)-1-propanol
• 英文别名: 3-(1H-inden-3-yl)propanol；3-(1H-inden-3-yl)propan-1-ol；3-(3-Indenyl)propanol；3-inden-3-yl-propan-1-ol；3-(3H-inden-1-yl)propan-1-ol
• CAS: 37848-93-4
• 化学式: C₁₂H₁₄O
• 分子量: 174.243
• InChiKey: TXNPXNAQCCSBKI-UHFFFAOYSA-N

物化性质

• 沸点：
  120 °C(Press: 0.1 Torr)
• 密度：
  1.079±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(3-茚基)-1-丙醇 在 氢氧化钾 、 乙醚 、 乙醇 、 五氯化磷 、 氰化钠 、 三溴化磷 、 苯 作用下， 生成 1-甲基芴
  参考文献：
  名称：

  February asthma outbreaks in NSW: a case control study

  摘要：

  Objectives: To investigate individual factors associated with an asthma outbreak among children aged one to 14 years in Sydney in February 1999. Methods: A case control study was undertaken with cases (n=92) defined as all children admitted to Sydney Children's Hospital for asthma in February 1999. Unmatched controls (n=76) were all children admitted for asthma in the previous three months. We obtained information by a structured telephone survey of parents. Logistic regression analyses were used to determine odds ratios for risk factors for hospital admission. Results: Mean age for hospital admission of 4.7 years for cases and 4.4 years for controls. The presence of one or more siblings reduced the risk of admission during an asthma outbreak (OR=0.59, 95% Cl 0.37 to 0.93). Children with older siblings aged 10 to 14 years were also less likely to be admitted (OR=0.3, 95% Cl 0.12 to 0.74). An age effect was observed. Other demographic, clinical and environmental characteristics, including smoking, were not associated with admission during the outbreak. Conclusions: The main findings of this study are the protective effect of siblings and an age-dependent effect in risk of hospital admission during an asthma outbreak. These findings are consistent with an infective cause of the outbreak. Implications: Children without siblings, particularly older siblings, appear to be at highest risk of hospital admission during an asthma outbreak. Environmental and other factors need to be examined to further explain the episodicity of such outbreaks and to determine means of predicting and preventing future episodes.

  DOI：

  10.1111/j.1467-842x.2001.tb00315.x
• 作为产物：
  描述：

  3-inden-3-yl-propionic acid ethyl ester 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 3-(3-茚基)-1-丙醇
  参考文献：
  名称：

  February asthma outbreaks in NSW: a case control study

  摘要：

  Objectives: To investigate individual factors associated with an asthma outbreak among children aged one to 14 years in Sydney in February 1999. Methods: A case control study was undertaken with cases (n=92) defined as all children admitted to Sydney Children's Hospital for asthma in February 1999. Unmatched controls (n=76) were all children admitted for asthma in the previous three months. We obtained information by a structured telephone survey of parents. Logistic regression analyses were used to determine odds ratios for risk factors for hospital admission. Results: Mean age for hospital admission of 4.7 years for cases and 4.4 years for controls. The presence of one or more siblings reduced the risk of admission during an asthma outbreak (OR=0.59, 95% Cl 0.37 to 0.93). Children with older siblings aged 10 to 14 years were also less likely to be admitted (OR=0.3, 95% Cl 0.12 to 0.74). An age effect was observed. Other demographic, clinical and environmental characteristics, including smoking, were not associated with admission during the outbreak. Conclusions: The main findings of this study are the protective effect of siblings and an age-dependent effect in risk of hospital admission during an asthma outbreak. These findings are consistent with an infective cause of the outbreak. Implications: Children without siblings, particularly older siblings, appear to be at highest risk of hospital admission during an asthma outbreak. Environmental and other factors need to be examined to further explain the episodicity of such outbreaks and to determine means of predicting and preventing future episodes.

  DOI：

  10.1111/j.1467-842x.2001.tb00315.x

文献信息

• Brønsted Acid‐Catalyzed Enantioselective Iodocycloetherification Enabled by Triphenylphosphine Selenide Cocatalysis
  作者：Sudip Guria、Constantin G. Daniliuc、Ulrich Hennecke

  DOI：10.1002/adsc.202100605

  日期：2021.8.3

  Enantioselective iodocycloetherifications can be conducted using sterically highly demanding BINOL-based phosphoric acid diesters as catalyst. To achieve highly enantioselective reactions, cocatalysis by triphenylphosphine selenide is necessary. With cocatalysis, good to excellent enantioselectivities can be achieved for a broad range of substrates using catalyst and cocatalyst loadings as low as 1 mol %

  对映选择性碘环醚化可以使用空间上要求很高的基于 BINOL 的磷酸二酯作为催化剂进行。为了实现高度对映选择性反应，需要通过硒化三苯基膦进行共催化。通过助催化，使用低至 1 mol % 的催化剂和助催化剂负载量，可以为广泛的底物实现良好到出色的对映选择性。三苯基膦硒化物助催化剂本身不会强烈影响非对映选择性，但会导致更高的反应性，并与基于 BINOL 的磷酸二酯结合使用，可实现良好的对映选择性。
• Fluorenylhydroxamic acids isomeric with the carcinogens N-fluoren-2-ylacetohydroxamic acid. Part I. Synthesis of N-fluoren-1-yl-, N-fluoren-3-yl-, and N-fluoren-4-ylacetohydroxamic acid
  作者：Yul Yost、H. R. Gutmann

  DOI：10.1039/j39690000345

  日期：——

  Three new fluorenylhydroxamic acids isomeric with the carcinogen N-fluoren-2-ylacetohydroxamic acid have been synthesized by partial catalytic reduction of the corresponding nitrofluorenes, prepared in turn by oxidation of the respective fluorenamines with peroxymaleic acid. A route to N([1-14C]fluoren-1-yl)acetamide and -acetohydroxamic acid by aromatization of the oxime of 3,4-dihydrofluoren-1 (2H)-one

  通过部分催化还原相应的硝基芴，合成了三种与致癌物N-芴-2-基乙酰氧肟酸同分异构的新芴基异羟肟酸，而相应的硝基芴又是用过氧马来酸氧化相应的芴胺而制得的。探索了一种通过Semmler-Wolff重排将3,4-二氢芴-1（2 H）-肟肟化的方法，制得N（[[ 14 C]芴-1-基）乙酰胺和-乙酰氧肟酸的途径。。通过TLC对产物的分析表明，当在有限量的乙酸酐存在下重排该肟时，亚胺为中间体。
• Diastereoselective Synthesis of CF₃- and CF₂H-Substituted Spiroethers from Aryl-Fused Cycloalkenylalkanols by Photoredox Catalysis
  作者：Naoki Noto、Takashi Koike、Munetaka Akita

  DOI：10.1021/acs.joc.6b00953

  日期：2016.8.19

  Simple synthesis of CF3- and CF2H-spiroethers from aryl-fused cycloalkenylalkanols by photoredox catalysis has been developed. Modification of the fluoromethylating reagents and the photoredox catalysts leads to both CF3- and CF2H-spiroetherification. The present photocatalytic system allows us to access a variety of new anti-fluoromethylated spiroethers in a highly selective manner.

  已经开发了通过光氧化还原催化从芳基稠合的环烯基链烷醇简单合成CF 3-和CF 2 H-螺醚的方法。氟甲基化试剂和光氧化还原催化剂的改性导致CF 3-和CF 2 H-螺醚化。本光催化系统使我们能够以高度选择性的方式获得各种新型的抗氟甲基化螺醚。
• US4044040A
  申请人：——

  公开号：US4044040A

  公开（公告）日：1977-08-23
• US4092318A
  申请人：——

  公开号：US4092318A

  公开（公告）日：1978-05-30