2-chloro-N-(4-hydroxy-3-nitro-phenyl)-acetamide | 89938-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-chloro-N-(4-hydroxy-3-nitro-phenyl)-acetamide
• 英文别名: 2-chloro-N-(4-hydroxy-3-nitrophenyl)acetamide
• CAS: 89938-33-0
• 化学式: C₈H₇ClN₂O₄
• 分子量: 230.608
• InChiKey: UAVFXAQMLALKCN-UHFFFAOYSA-N

物化性质

• 熔点：
  135-136 °C
• 沸点：
  426.0±45.0 °C(Predicted)
• 密度：
  1.599±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  95.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-硝基-4-氨基苯酚 、 氯乙酰氯 在 sodium hydroxide 作用下， 以 水 为溶剂， 以78%的产率得到2-chloro-N-(4-hydroxy-3-nitro-phenyl)-acetamide
  参考文献：
  名称：

  Synthesis of α-chloroamides in water

  摘要：

  The reaction between chloroacetyl chloride and mono- or bis-aliphatic or aromatic amines in water under basic or neutral conditions gives rise to the formation of a variety of functionalized alpha-chloroamides. The resulting products were obtained as solids in moderate to good yields, upon precipitation and isolation by filtration. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.06.090

文献信息

• Synthesis of α-chloroamides in water
  作者：Andrew J. Harte、Thorfinnur Gunnlaugsson

  DOI：10.1016/j.tetlet.2006.06.090

  日期：2006.8

  The reaction between chloroacetyl chloride and mono- or bis-aliphatic or aromatic amines in water under basic or neutral conditions gives rise to the formation of a variety of functionalized alpha-chloroamides. The resulting products were obtained as solids in moderate to good yields, upon precipitation and isolation by filtration. (c) 2006 Elsevier Ltd. All rights reserved.