甲基戊基甲基膦酸酯 | 170082-80-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 甲基戊基甲基膦酸酯
• 英文名称: methyl n-pentyl methylphosphonate
• 英文别名: methyl pentyl methylphosphonate；1-[methoxy(methyl)phosphoryl]oxypentane
• CAS: 170082-80-1
• 化学式: C₇H₁₇O₃P
• 分子量: 180.184
• InChiKey: BFVHKYLTFOSXEI-UHFFFAOYSA-N

物化性质

• 沸点：
  226.4±9.0 °C(Predicted)
• 密度：
  0.995±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methylphosphonic acid monopentyl ester 、 三甲基硅烷化重氮甲烷 在 甲醇 作用下， 以 四氢呋喃 、 苯 为溶剂， 生成 甲基戊基甲基膦酸酯
  参考文献：
  名称：

  PREPARATION, DERIVATIZATION WITH TRIMETHYLSILYLDIAZOMETHANE, AND GC/MS ANALYSIS OF A “POOL” OF ALKYL METHYLPHOSPHONIC ACIDS FOR USE AS QUALITATIVE STANDARDS IN SUPPORT OF COUNTERTERRORISM AND THE CHEMICAL WEAPONS CONVENTION

  摘要：

  There are hundreds of nerve agents in the class of alkyl methylphosphonofluoridates covered by Schedule 1 of the CWC (Chemical Weapons Convention). Hydrolysis of these sarin-like nerve agents results in all equal number of alkyl methylphosphonic acids. These allkyl methylphosphonic acids are persistent and provide good evidence of specific agent production or use. In order to support the CWC and counterterrorism activities, it is desirable to have ready access to each of these hydrolysis products for use as qualitative standards. A means for simultaneously producing multiple alkyl methylphosphonates from methylphosphonic acid and the corresponding alcohols was developed. Derivatization of these alkyl methylphosphonic acids with trimethylsilyldiazomethane yields the corresponding methyl esters which are suitable for GC/MS analysis.

  DOI：

  10.1080/10426500490459632

文献信息

• LIPASE INHIBITING POLYMERS
  申请人：Geltex Pharmaceuticals, Inc.

  公开号：EP1043982A2

  公开（公告）日：2000-10-18
• [EN] LIPASE INHIBITING POLYMERS<br/>[FR] POLYMERES INHIBITEURS DE LIPASE
  申请人：——

  公开号：WO1999034786A2

  公开（公告）日：1999-07-15

  [EN] The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.
  [FR] L'invention concerne un procédé permettant de traiter l'obésité chez un sujet, en administrant à celui-ci un polymère substitué avec un ou plusieurs groupes qui inhibent les lipases, c'est-à-dire les enzymes responsables de l'hydrolyse des graisses. L'invention concerne en outre les polymères utilisés dans le cadre des procédés décrits, ainsi que des intermédiaires et des procédés nouveaux permettant d'élaborer les polymères considérés.